World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
11456
World Ranking
13857
National Ranking
5862

Overview

Jacek Zielonka is affiliated with the Medical College of Wisconsin in the United States. Their research spans multiple disciplines primarily within Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on specialized subfields including Physiology, Molecular Biology, Biochemistry, Spectroscopy, and Immunology.

The scientist's work covers several main topics such as:

  • Nitric Oxide and Endothelin Effects
  • Sulfur Compounds in Biology
  • Molecular Sensors and Ion Detection
  • Electrochemical sensors and biosensors
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Electron Spin Resonance Studies
  • Eicosanoids and Hypertension Pharmacology

Zielonka has contributed to numerous research articles, with recent important publications including:

  • Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon (2020, Redox Biology)
  • Alcohol-induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids (2020, Free Radical Biology and Medicine)
  • Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology (2020, Frontiers in Chemistry)
  • Health position paper and redox perspectives - Disease burden by transportation noise (2023, Redox Biology)
  • Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases (2024, Redox Biology)

Frequent coauthors collaborating with Zielonka include Adam Sikora, Balaraman Kalyanaraman, Radosław Podsiadły, Aleksandra Grzelakowska, and Radosław Michalski. These ongoing partnerships reflect a collaborative research environment.

The scientist has published extensively in several venues, with a notable number of publications in:

  • Free Radical Biology and Medicine (14 publications)
  • Redox Biochemistry and Chemistry (4 publications)
  • Redox Biology (3 publications)
  • Dyes and Pigments (3 publications)
  • Antioxidants (3 publications)

Best Publications

  • Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

    Jacek Zielonka;Joy Joseph;Adam Sikora;Micael Hardy

  • Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth

    Jacek Zielonka;B. Kalyanaraman

  • Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine

    Jacek Zielonka;Jeannette Vasquez-Vivar;Balaraman Kalyanaraman

  • Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite

    Adam Sikora;Jacek Zielonka;Marcos Lopez;Joy Joseph

  • European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

    Javier Egea;Isabel Fabregat;Yves M Frapart;Pietro Ghezzi

  • Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death

    Gang Cheng;Jacek Zielonka;Brian P Dranka;Donna McAllister

  • A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds.

    Balaraman Kalyanaraman;Gang Cheng;Micael Hardy;Olivier Ouari

  • Peroxynitrite Is the Major Species Formed from Different Flux Ratios of Co-generated Nitric Oxide and Superoxide DIRECT REACTION WITH BORONATE-BASED FLUORESCENT PROBE

    Jacek Zielonka;Adam Sikora;Adam Sikora;Joy Joseph;Balaraman Kalyanaraman

  • Global Profiling of Reactive Oxygen and Nitrogen Species in Biological Systems HIGH-THROUGHPUT REAL-TIME ANALYSES

    Jacek Zielonka;Monika Zielonka;Adam Sikora;Jan Adamus

  • Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.

    Gang Cheng;Qi Zhang;Jing Pan;Yongik Lee

  • Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies.

    Balaraman Kalyanaraman;Gang Cheng;Micael Hardy;Olivier Ouari

  • Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy.

    Partha Mukhopadhyay;Béla Horváth;Béla Horváth;Zsuzsanna Zsengellér;Jacek Zielonka

  • Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

    Karunakaran Chandran;Deepika Aggarwal;Raymond Q. Migrino;Joy Joseph

  • Transient species in the stepwise interconversion of NADH and NAD

    Jerzy Gȩbicki;and Andrzej Marcinek;Jacek Zielonka

  • Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells.

    Gang Cheng;Jacek Zielonka;Olivier Ouari;Marcos Lopez

  • HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements

    Jacek Zielonka;Micael Hardy;B. Kalyanaraman

  • The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone

    V. Ashutosh Rao;Sarah R. Klein;Spencer J. Bonar;Jacek Zielonka

  • On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation.

    Jacek Zielonka;J. David Lambeth;Balaraman Kalyanaraman

  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

    Gang Cheng;Jacek Zielonka;Donna M McAllister;A Craig Mackinnon

  • Radical scavenging properties of genistein.

    Jacek Zielonka;Jerzy Gębicki;Grzegorz Grynkiewicz

Frequent Co-Authors

Balaraman Kalyanaraman
Balaraman Kalyanaraman Medical College of Wisconsin
Joy Joseph
Joy Joseph Medical College of Wisconsin
Olivier Ouari
Olivier Ouari Aix-Marseille University
Anumantha G. Kanthasamy
Anumantha G. Kanthasamy University of Georgia
Roy L. Silverstein
Roy L. Silverstein Medical College of Wisconsin
Ming You
Ming You Medical College of Wisconsin
Pal Pacher
Pal Pacher National Institutes of Health
Narayan G. Avadhani
Narayan G. Avadhani University of Pennsylvania
Rafael Radi
Rafael Radi University of the Republic
Michael P. Murphy
Michael P. Murphy University of Cambridge

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