D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 84 Citations 21,137 208 World Ranking 10198 National Ranking 5368

Research.com Recognitions

Awards & Achievements

1958 - Fellow of the American Association for the Advancement of Science (AAAS)

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Enzyme
  • Biochemistry

Albert Sjoerdsma mainly investigates Internal medicine, Endocrinology, Biochemistry, Pharmacology and Serotonin. His study focuses on the intersection of Internal medicine and fields such as Hydroxylation with connections in the field of P chlorophenylalanine. His study in the fields of Norepinephrine, Epinephrine, Catecholamine and Excretion under the domain of Endocrinology overlaps with other disciplines such as Decarboxylase inhibitor.

His study on Ornithine, Putrescine, Enzyme and Tryptophan is often connected to Tryptophan hydroxylase as part of broader study in Biochemistry. His Histamine study, which is part of a larger body of work in Pharmacology, is frequently linked to In patient and In vivo, bridging the gap between disciplines. The study incorporates disciplines such as Slow-wave sleep, Tryptamine, Respiratory distress and Aromatic amino acids in addition to Serotonin.

His most cited work include:

  • ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART (939 citations)
  • BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE. (785 citations)
  • Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor (415 citations)

What are the main themes of his work throughout his whole career to date?

Albert Sjoerdsma spends much of his time researching Internal medicine, Endocrinology, Pharmacology, Biochemistry and Serotonin. Internal medicine and Enzyme are commonly linked in his work. His Endocrinology study is mostly concerned with Norepinephrine, Excretion, Catecholamine, Spontaneously hypertensive rat and Urinary system.

His studies in Norepinephrine integrate themes in fields like Epinephrine, Tyrosine and Tyrosine hydroxylase. His Pharmacology study incorporates themes from In vitro and Monoamine oxidase. His study in Serotonin is interdisciplinary in nature, drawing from both Tryptophan, Carcinoid syndrome, Malignant Carcinoid Syndrome and Histamine.

He most often published in these fields:

  • Internal medicine (48.48%)
  • Endocrinology (43.72%)
  • Pharmacology (23.38%)

What were the highlights of his more recent work (between 1987-2020)?

  • Pharmacology (23.38%)
  • Polyamine (6.49%)
  • Plasmodium falciparum (2.60%)

In recent papers he was focusing on the following fields of study:

His main research concerns Pharmacology, Polyamine, Plasmodium falciparum, In vitro and Monoamine oxidase. His work in the fields of Tricyclic overlaps with other areas such as Desipramine. His Polyamine research includes elements of Scientific method, Combinatorial chemistry, Ornithine and Ornithine decarboxylase.

His work deals with themes such as Amino acid and Brainstem, which intersect with Monoamine oxidase. His Monoamine oxidase inhibitor research incorporates themes from Endocrinology and Internal medicine. His work in the fields of Endocrinology, such as Blood pressure, intersects with other areas such as Decarboxylase inhibitor and In patient.

Between 1987 and 2020, his most popular works were:

  • Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. (207 citations)
  • Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria (77 citations)
  • Anti-HIV activity of castanospermine analogues. (70 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Enzyme
  • Biochemistry

Albert Sjoerdsma mainly focuses on Pharmacology, Monoamine oxidase, Biochemistry, Polyamine and Plasmodium falciparum. His research investigates the connection with Pharmacology and areas like Chloroquine which intersect with concerns in Virology and Efflux. His Monoamine oxidase research includes themes of Blood pressure and Brainstem.

When carried out as part of a general Biochemistry research project, his work on Hypoxanthine and Eflornithine is frequently linked to work in Infestation, therefore connecting diverse disciplines of study. Albert Sjoerdsma has researched Monoamine oxidase inhibitor in several fields, including Internal medicine, Central nervous system and Endocrinology. His study in the field of Peripheral also crosses realms of Decarboxylase inhibitor.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART

Morton Levitt;Sydney Spector;Albert Sjoerdsma;Sidney Udenfriend.
Journal of Pharmacology and Experimental Therapeutics (1965)

1493 Citations

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

S. Spector;A. Sjoerdsma;S. Udenfriend.
Journal of Pharmacology and Experimental Therapeutics (1965)

1252 Citations

Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor

Walter Lovenberg;Eric Jequier;Albert Sjoerdsma.
Science (1967)

642 Citations

Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.

Eric Jéquier;Walter Lovenberg;Albert Sjoerdsma.
Molecular Pharmacology (1967)

581 Citations

Polyamine metabolism: a potential therapeutic target in trypanosomes

CJ Bacchi;HC Nathan;SH Hutner;PP McCann.
Science (1980)

507 Citations

Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold.

Robert Gordon;Sydney Spector;Albert Sjoerdsma;Sidney Udenfriend.
Journal of Pharmacology and Experimental Therapeutics (1966)

471 Citations

Altered urinary kallikrein excretion in human hypertension.

HarryS. Margolius;JohnJ. Pisano;Ronald Geller;Albert Sjoerdsma.
The Lancet (1971)

431 Citations

Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo.

Donald S. Robinson;Walter Lovenberg;Harry Keiser;Albert Sjoerdsma.
Biochemical Pharmacology (1968)

397 Citations

Chemotherapeutic implications of polyamine biosynthesis inhibition.

Albert Sjoerdsma;Paul J Schlechter.
Clinical Pharmacology & Therapeutics (1984)

334 Citations

A clinical, physiologic and biochemical study of patients with malignant carcinoid (argentaffinoma).

Albert Sjoerdsma;Herbert Weissbach;Sidney Udenfriend.
The American Journal of Medicine (1956)

334 Citations

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