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Genetics

D-Index
51
Citations
27749
World Ranking
3821
National Ranking
1649

Overview

Adam C. Naj is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a strong emphasis on Genetics and Molecular Biology as subfields. Additional areas of study include Physiology, Neurology, and Cancer Research.

The scientist has published extensively on topics such as Genetic Associations and Epidemiology, Bioinformatics and Genomic Networks, Alzheimer's disease research and treatments, Genomics and Rare Diseases, Epigenetics and DNA Methylation, Genetics and Neurodevelopmental Disorders, and MicroRNA in disease regulation.

Adam C. Naj has contributed to a variety of publication venues throughout their career. The most frequent among these are:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Alzheimer s Disease
  • Nature Genetics

Their recent papers include the following:

  • New insights into the genetic etiology of Alzheimer's disease and related dementias (2022), published in Nature Genetics
  • Common variants in Alzheimer's disease and risk stratification by polygenic risk scores (2021), published in Nature Communications
  • Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel (2020), published in JAMA Neurology
  • Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease (2022), published in Nature Genetics
  • New insights on the genetic etiology of Alzheimer's and related dementia (2020), published in bioRxiv (Cold Spring Harbor Laboratory)

Throughout their career, Adam C. Naj has collaborated frequently with several coauthors. Notable frequent coauthors include:

  • Eden R. Martin
  • William S. Bush
  • Brian W. Kunkle
  • Lindsay A. Farrer
  • Jonathan L. Haines

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Seven new loci associated with age-related macular degeneration

    Lars G. Fritsche;Lars G. Fritsche;Wei Chen;Wei Chen;Matthew Schu;Brian L. Yaspan

  • Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4, and the Risk of Late-Onset Alzheimer Disease in African Americans

    Christiane Reitz;Gyungah Jun;Adam Naj;Ruchita Rajbhandary

  • Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes.

    Gyungah Jun;Adam C. Naj;Gary W. Beecham;Li San Wang

  • Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

    Eric M Reiman;Joseph F Arboleda-Velasquez;Yakeel T Quiroz;Matthew J Huentelman

  • Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

    David C. Whitcomb;Jessica LaRusch;Alyssa M. Krasinskas;Lambertus Klei

  • Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.

    Gary W. Beecham;Kara Hamilton;Adam C. Naj;Eden R. Martin

  • A novel Alzheimer disease locus located near the gene encoding tau protein

    G. Jun;C. A. Ibrahim-Verbaas;M. Vronskaya;J-C Lambert;J-C Lambert;J-C Lambert

  • A statistical framework for cross-tissue transcriptome-wide association analysis.

    Yiming Hu;Mo Li;Qiongshi Lu;Haoyi Weng

  • Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    Itziar de Rojas;Itziar de Rojas;Sonia Moreno-Grau;Sonia Moreno-Grau;Niccolo Tesi;Benjamin Grenier-Boley

  • Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

    Joshua C Bis;Xueqiu Jian;Brian W Kunkle;Yuning Chen

  • Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

    Giovanni Coppola;Subashchandrabose Chinnathambi;Jason Ji Yong Lee;Beth A. Dombroski

  • Genome-wide association study of the rate of cognitive decline in Alzheimer's disease

    Richard Sherva;Yorghos Tripodis;David A. Bennett;Lori B. Chibnik;Lori B. Chibnik;Lori B. Chibnik

  • Genomic variants, genes, and pathways of Alzheimer's disease: An overview.

    Adam C. Naj;Gerard D. Schellenberg

  • Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

    Adam C. Naj;Gyungah Jun;Christiane Reitz;Brian W. Kunkle

  • The Alzheimer's Disease Sequencing Project: Study design and sample selection.

    Gary W. Beecham;J. C. Bis;E. R. Martin;S. H. Choi

  • Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

    Joshua C. Bis;Xueqiu Jian;Brian W. Kunkle;Yuning Chen

Frequent Co-Authors

Margaret A. Pericak-Vance
Margaret A. Pericak-Vance University of Miami
Gerard D. Schellenberg
Gerard D. Schellenberg University of Pennsylvania
Eden R. Martin
Eden R. Martin University of Miami
Li-San Wang
Li-San Wang University of Pennsylvania
Lindsay A. Farrer
Lindsay A. Farrer Boston University
Gary W. Beecham
Gary W. Beecham University of Miami
Jonathan L. Haines
Jonathan L. Haines Case Western Reserve University
Richard Mayeux
Richard Mayeux Columbia University
Sudha Seshadri
Sudha Seshadri The University of Texas Health Science Center at San Antonio
Eric Boerwinkle
Eric Boerwinkle The University of Texas Health Science Center at Houston

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