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A. Cristina Rego

A. Cristina Rego

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
9952
World Ranking
14558
National Ranking
59

Overview

A. Cristina Rego is affiliated with the University of Coimbra in Portugal and has published extensively in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their research primarily focuses on Molecular Biology, Cellular and Molecular Neuroscience, Physiology, Neurology, and Pharmacology.

The main topics of their work involve mitochondrial function and pathology, genetic neurodegenerative diseases, and Alzheimer's disease research and treatments. Additional research interests include neuroscience and neuropharmacology, autophagy in disease and therapy, cholinesterase and neurodegenerative diseases, as well as metabolism and genetic disorders.

Frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory), Hematology Transfusion and Cell Therapy, Endoscopy, International Journal of Molecular Sciences, and Free Radical Biology and Medicine.

Collaborations have been frequent with several researchers, including Ildete L. Ferreira, Carla Lopes, Sandra I. Mota, Lígia Fão, and Patrícia Coelho.

Significant recent papers authored or co-authored by A. Cristina Rego include:

  • "Apoe4 and Alzheimer's Disease Pathogenesis-Mitochondrial Deregulation and Targeted Therapeutic Strategies" (2023, International Journal of Molecular Sciences)
  • "Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics" (2020, Free Radical Biology and Medicine)
  • "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neurons" (2020, Journal of Neuroinflammation)
  • "The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models" (2021, Neurotherapeutics)
  • "Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases" (2022, Ageing Research Reviews)

Best Publications

  • Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases

    A. Cristina Rego;Catarina R. Oliveira

  • Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

    Manus W. Ward;A. Cristina Rego;Bruno G. Frenguelli;David G. Nicholls

  • Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

    Lígia Fão;Sandra I. Mota;A. Cristina Rego

  • An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease.

    Paula I Moreira;Ana I Duarte;Maria S Santos;A Cristina Rego

  • Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

    Sandra I. Mota;Ildete L. Ferreira;A. Cristina Rego

  • Mitochondrial-Dependent Ca2+ Handling in Huntington's Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors

    Jorge M. A. Oliveira;Sylvia Chen;Sandra Almeida;Rebeccah Riley

  • Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice.

    Jorge M. A. Oliveira;Mika B. Jekabsons;Sylvia Chen;Amy Lin

  • Antioxidant effect of flavonoids after ascorbate/Fe2+-induced oxidative stress in cultured retinal cells

    Filipe Miguel Areias;A.Cristina Rego;Catarina R Oliveira;Rosa Maria Seabra

  • Effect of amyloid beta-peptide on permeability transition pore: A comparative study

    Paula I. Moreira;Maria S. Santos;António Moreno;A. Cristina Rego

  • Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression

    Ana I. Duarte;Paulo Santos;Catarina R. Oliveira;Maria S. Santos

  • Mitochondrial Dysfunction in Huntington's Disease.

    Catarina Carmo;Luana Naia;Carla Lopes;A. Cristina Rego

  • Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

    Raquel Pinho;Raquel Pinho;Isabel Paiva;Kristina Gotovac Jercic;Luis Fonseca-Ornelas

  • Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington's disease knock-in striatal cells.

    Márcio Ribeiro;Tatiana R. Rosenstock;Ana M. Oliveira;Catarina R. Oliveira

  • Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.

    Isabel Paiva;Raquel Pinho;Raquel Pinho;Maria Angeliki Pavlou;Magali Hennion

  • Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine.

    Teresa Cunha-Oliveira;A. Cristina Rego;Sandra M. Cardoso;Fernanda Borges

  • Insulin Restores Metabolic Function in Cultured Cortical Neurons Subjected to Oxidative Stress

    Ana I. Duarte;Teresa Proença;Catarina R. Oliveira;Maria S. Santos

  • Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models

    Luana Naia;Tatiana R. Rosenstock;Ana M. Oliveira;Sofia I. Oliveira-Sousa

  • Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis

    Joana Gil;Sandra Almeida;Catarina R. Oliveira;A.Cristina Rego

  • Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells.

    Ana Cristina Rego;Maria S. Santos;Catarina R. Oliveira

  • Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses.

    Ana I. Duarte;Maria S. Santos;Catarina R. Oliveira;A. Cristina Rego

Frequent Co-Authors

Catarina R. Oliveira
Catarina R. Oliveira University of Coimbra
Michael R. Hayden
Michael R. Hayden University of British Columbia
Maria S. Santos
Maria S. Santos University of Coimbra
David G. Nicholls
David G. Nicholls Buck Institute for Research on Aging
Sandra M. Cardoso
Sandra M. Cardoso University of Coimbra
Sandrine Humbert
Sandrine Humbert Grenoble Alpes University
Fernanda Borges
Fernanda Borges University of Porto
Frédéric Saudou
Frédéric Saudou Grenoble Alpes University
Luís Pereira de Almeida
Luís Pereira de Almeida University of Coimbra
Tiago F. Outeiro
Tiago F. Outeiro University of Göttingen

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