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Biology and Biochemistry

D-Index
71
Citations
18480
World Ranking
6629
National Ranking
3083

Overview

William P. Schiemann is affiliated with Case Western Reserve University in the United States. Their research spans several fields, primarily focused on biochemical, genetic, and molecular biology aspects with an emphasis on cancer research and related medical applications.

The scientist's work covers multiple specialized subfields including molecular biology, cancer research, oncology, physiology, and pulmonary and respiratory medicine. Their research topics often focus on telomeres, telomerase, and senescence, RNA modifications associated with cancer, molecular mechanisms underpinning cancer, histone deacetylase inhibitors, advanced breast cancer therapies, cancer research and treatments, and epigenetics and DNA methylation.

Some recent papers authored or co-authored by the scientist include:

  • Epithelial-Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance, 2020, Molecular Cancer Research
  • Telomerase in Cancer: Function, Regulation, and Clinical Translation, 2022, Cancers
  • Epigenetic plasticity in metastatic dormancy: mechanisms and therapeutic implications, 2020, Annals of Translational Medicine
  • SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling, 2021, Science Signaling
  • SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness, 2020, Life Science Alliance

Frequent co-authors collaborating with William P. Schiemann include Nathaniel Robinson, Kimberly A. Parker, Derek J. Taylor, Alex J. Gooding, and Barbara J. Schiemann.

Their research publications are commonly found in prominent journals such as Cancers, Annals of Translational Medicine, Journal of Cancer Metastasis and Treatment, Molecular Cancer Research, and Science Signaling.

Best Publications

  • Role of transforming growth factor beta in human disease.

    Gerard C. Blobe;William P. Schiemann;Harvey F. Lodish

  • Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans

    Suraj Peri;Suraj Peri;J. Daniel Navarro;J. Daniel Navarro;Ramars Amanchy;Troels Z. Kristiansen;Troels Z. Kristiansen

  • TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

    Riki Perlman;William P. Schiemann;Mary W. Brooks;Harvey F. Lodish

  • MECHANISMS OF THE EPITHELIAL-MESENCHYMAL TRANSITION BY TGF-BETA

    Michael K Wendt;Tressa M Allington;William P Schiemann

  • Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages

    Celio G. Freire-de-Lima;Yi Qun Xiao;Shyra J. Gardai;Donna L. Bratton

  • TGF-β upregulates miR-181a expression to promote breast cancer metastasis

    Molly A. Taylor;Khalid Sossey-Alaoui;Cheryl L. Thompson;David Danielpour

  • Transforming growth factor-β and the hallmarks of cancer.

    Maozhen Tian;Jason R. Neil;William P. Schiemann

  • Src phosphorylates Tyr284 in tgf-β type II receptor and regulates TGF-β stimulation of p38 MAPK during breast cancer cell proliferation and invasion

    Amy J. Galliher;William P. Schiemann

  • Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-β

    Yi Qun Xiao;Ken Malcolm;G. Scott Worthen;Shyra J. Gardai

  • The Pathophysiology of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β in Normal and Malignant Mammary Epithelial Cells

    Molly A. Taylor;Jenny G. Parvani;William P. Schiemann

  • The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling

    Douglas S. Micalizzi;Kimberly L. Christensen;Paul Jedlicka;Ricardo D. Coletta;Ricardo D. Coletta

  • β3 Integrin and Src facilitate transforming growth factor-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells

    Amy J Galliher;William P Schiemann

  • Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression

    Michael K. Wendt;Maozhen Tian;William P. Schiemann

  • The TGF-β paradox in human cancer: an update

    Maozhen Tian;William P Schiemann

  • The Relevance of the TGF-β Paradox to EMT-MET Programs

    Chevaun D. Morrison;Jenny G. Parvani;William P. Schiemann

  • Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression.

    Michael K. Wendt;Jason A. Smith;William P. Schiemann

  • Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer

    Michael K. Wendt;Molly A. Taylor;Barbara J. Schiemann;William P. Schiemann

  • STAT3 and epithelial-mesenchymal transitions in carcinomas.

    Michael K Wendt;Nikolas Balanis;Cathleen R Carlin;William P Schiemann

  • Context-specific Effects of Fibulin-5 (DANCE/EVEC) on Cell Proliferation, Motility, and Invasion FIBULIN-5 IS INDUCED BY TRANSFORMING GROWTH FACTOR-β AND AFFECTS PROTEIN KINASE CASCADES

    William P. Schiemann;William P. Schiemann;Gerard C. Blobe;Gerard C. Blobe;Dario E. Kalume;Akhilesh Pandey

  • Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-β through a PGE2-dependent mechanisms

    Jason R. Neil;Kyle M. Johnson;Raphael A. Nemenoff;William P. Schiemann

Frequent Co-Authors

Edward F. Plow
Edward F. Plow Cleveland Clinic Lerner College of Medicine
Gerard C. Blobe
Gerard C. Blobe Duke University
Akhilesh Pandey
Akhilesh Pandey Mayo Clinic
Donna L. Bratton
Donna L. Bratton University of Colorado Anschutz Medical Campus
Peter M. Henson
Peter M. Henson National Jewish Health
Aristidis Moustakas
Aristidis Moustakas Uppsala University
David Danielpour
David Danielpour Case Western Reserve University
James L. Maller
James L. Maller University of Colorado Denver
Jenny C. Chang
Jenny C. Chang Houston Methodist

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