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D-Index & Metrics

Genetics

D-Index
61
Citations
36008
World Ranking
3013
National Ranking
78

Overview

Siu Tsan Yuen is affiliated with the University of Hong Kong in China. Their research primarily intersects the fields of Medicine and Biochemistry, Genetics, and Molecular Biology with a focused engagement in Oncology, Pathology and Forensic Medicine, Cancer Research, Molecular Biology, and Gastroenterology.

The scientist's work covers critical topics such as Cancer Cells and Metastasis, Genetic Factors in Colorectal Cancer, Cancer Genomics and Diagnostics, Gastrointestinal Tumor Research and Treatment, Colorectal Cancer Treatments and Studies, Colorectal Cancer Screening and Detection, and Genomics and Phylogenetic Studies.

Among recent publications, Siu Tsan Yuen has contributed to the following papers:

  • Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles, 2020, Gut
  • Mutational landscape of normal epithelial cells in Lynch Syndrome patients, 2022, Nature Communications
  • Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models, 2022, Gut
  • The somatic mutation landscape of normal gastric epithelium, 2025, Nature
  • Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression, 2024, Gut

Their frequent coauthors include Suet Yi Leung, Helen H.N. Yan, Hoi Cheong Siu, Siu Lun Ho, and Sarah S K Yue. This collaboration network reflects shared contributions across several research projects and publications.

Publications have been primarily disseminated through scientific venues such as:

  • Gut (with three publications)
  • Nature Communications
  • Nature
  • The Journal of Nutrition Health & Aging
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Mutations of the BRAF gene in human cancer

    Helen Davies;Graham R. Bignell;Charles Cox;Philip Stephens

  • Patterns of somatic mutation in human cancer genomes

    Christopher Greenman;Philip Stephens;Raffaella Smith;Gillian L. Dalgliesh

  • MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma

    Aaron J. Schetter;Suet Yi Leung;Jane J. Sohn;Krista A. Zanetti

  • Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial.

    Benjamin Chun-Yu Wong;Shiu Kum Lam;Wai Man Wong;Jian Shun Chen

  • Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study

    H. J. N. Andreyev;A. R. Norman;D. Cunningham;J. Oates

  • Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

    Kai Wang;Siu Tsan Yuen;Jiangchun Xu;Siu Po Lee

  • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

    Gijs Van Haaften;Gillian L Dalgliesh;Helen Davies;Lina Chen

  • Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

    Marjolijn J L Ligtenberg;Roland P Kuiper;Tsun Leung Chan;Tsun Leung Chan;Monique Goossens

  • Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

    Kai Wang;Junsuo Kan;Siu Tsan Yuen;Stephanie T Shi

  • Lung cancer: intragenic ERBB2 kinase mutations in tumours.

    Philip Stephens;Chris Hunter;Graham Bignell;Sarah Edkins

  • Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors.

    Cynthia Kosinski;Vivian S. W. Li;Annie S. Y. Chan;Ji Zhang

  • Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

    Helen Davies;Chris Hunter;Raffaella Smith;Philip Stephens

  • A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

    Helen H.N. Yan;Hoi Cheong Siu;Simon Law;Siu Lun Ho

  • Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.

    Siu T. Yuen;Helen Davies;Tsun L. Chan;Judy W. Ho

  • hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.

    Suet Yi Leung;Siu Tsan Yuen;Lap Ping Chung;Kent Man Chu

  • Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Bryony A Thompson;Bryony A Thompson;Amanda B Spurdle;John-Paul Plazzer;Marc S Greenblatt

  • BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.

    Tsun L. Chan;Wei Zhao;Suet Y. Leung;Siu T. Yuen

  • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

    Philip Stephens;Sarah Edkins;Helen Davies;Christopher Greenman

  • Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer.

    Tsun Leung Chan;Siu Tsan Yuen;Siu Tsan Yuen;Chi Kwan Kong;Yee Wai Chan

  • Variation in Gene Expression Patterns in Human Gastric Cancers

    Xin Chen;Suet Y. Leung;Siu T. Yuen;Kent-Man Chu

Frequent Co-Authors

Suet Yi Leung
Suet Yi Leung University of Hong Kong
Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Benjamin C.Y. Wong
Benjamin C.Y. Wong University of Hong Kong
Helen Davies
Helen Davies University of Cambridge
P. Andrew Futreal
P. Andrew Futreal The University of Texas MD Anderson Cancer Center
Richard Wooster
Richard Wooster Wellcome Sanger Institute
Graham R. Bignell
Graham R. Bignell Wellcome Sanger Institute
Simon Law
Simon Law University of Hong Kong
Jon W. Teague
Jon W. Teague Wellcome Sanger Institute
Sarah Edkins
Sarah Edkins Cardiff University

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