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Biology and Biochemistry

D-Index
66
Citations
18227
World Ranking
8557
National Ranking
232

Overview

Roman S. Polishchuk is affiliated with the Telethon Institute Of Genetics And Medicine in Italy and has a significant body of work in the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research contributions span several subfields including Nutrition and Dietetics, Molecular Biology, Physiology, Oncology, and Health, Toxicology and Mutagenesis.

The scientist's main research topics focus on Trace Elements in Health, Heavy Metal Exposure and Toxicity, Drug Transport and Resistance Mechanisms, Calcium Signaling and Nucleotide Metabolism, Virus-Based Gene Therapy Research, Lipid Membrane Structure and Behavior, and Alzheimer's Disease Research and Treatments.

Roman S. Polishchuk has co-authored multiple publications with frequent collaborators such as Raffaella Petruzzelli, Elena V. Polishchuk, Federico Catalano, Elena Polishchuk, and Maria Antonietta De Matteis.

They have published in various scientific journals and repositories, with frequent appearances in venues including Human Molecular Genetics, Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), and Nature Reviews. Cancer.

Selected recent papers include:

  • Connecting copper and cancer: from transition metal signalling to metalloplasia, 2021, Nature Reviews. Cancer
  • The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle, 2022, Nature
  • Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin, 2020, Cancers
  • Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content, 2020, Journal of Neuroscience
  • Full-length ATP7B reconstituted through protein trans-splicing corrects Wilson disease in mice, 2022, Molecular Therapy - Methods & Clinical Development

Best Publications

  • A Gene Network Regulating Lysosomal Biogenesis and Function

    Marco Sardiello;Michela Palmieri;Alberto di Ronza;Diego Luis Medina

  • Connecting copper and cancer: from transition metal signalling to metalloplasia.

    Eva J Ge;Ashley I Bush;Angela Casini;Paul A Cobine

  • Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

    Diego L Medina;Alessandro Fraldi;Valentina Bouche;Fabio Annunziata

  • Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex

    Benjamin J. Nichols;Anne K. Kenworthy;Roman S. Polishchuk;Robert Lodge

  • Maintenance of Golgi structure and function depends on the integrity of ER export

    Theresa H. Ward;Roman S. Polishchuk;Steven H Caplan;Koret Hirschberg

  • Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

    Giovanni D’Angelo;Elena Polishchuk;Giuseppe Di Tullio;Michele Santoro

  • Golgi Membranes Are Absorbed into and Reemerge from the ER during Mitosis

    Kristien J.M Zaal;Carolyn L Smith;Roman S Polishchuk;Nihal Altan

  • Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments

    Alvar Trucco;Roman S Polishchuk;Oliviano Martella;Alessio Di Pentima

  • Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

    Carmine Spampanato;Erin Feeney;Lishu Li;Monica Cardone

  • Correlative Light-Electron Microscopy Reveals the Tubular-Saccular Ultrastructure of Carriers Operating between Golgi Apparatus and Plasma Membrane

    Roman S. Polishchuk;Elena V. Polishchuk;Pierfrancesco Marra;Saverio Alberti

  • A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane.

    Steve Caplan;Naava Naslavsky;Lisa M. Hartnell;Robert Lodge

  • Transport through the Golgi Apparatus by Rapid Partitioning within a Two-Phase Membrane System

    George H. Patterson;Koret Hirschberg;Roman S. Polishchuk;Daniel Gerlich

  • Mitochondria Are Linked to Calcium Stores in Striated Muscle by Developmentally Regulated Tethering Structures

    Simona Boncompagni;Ann E. Rossi;Massimo Micaroni;Galina V. Beznoussenko

  • Delivery of raft-associated, GPI-anchored proteins to the apical surface of polarized MDCK cells by a transcytotic pathway

    Roman Polishchuk;Roman Polishchuk;Alessio Di Pentima;Jennifer Lippincott-Schwartz

  • Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

    Elena V. Polishchuk;Mafalda Concilli;Simona Iacobacci;Giancarlo Chesi

  • Mechanism of constitutive export from the golgi: bulk flow via the formation, protrusion, and en bloc cleavage of large trans-golgi network tubular domains.

    Elena V. Polishchuk;Alessio Di Pentima;Alberto Luini;Roman S. Polishchuk

  • Effective delivery of large genes to the retina by dual AAV vectors

    Ivana Trapani;Pasqualina Colella;Andrea Sommella;Carolina Iodice

  • Small cargo proteins and large aggregates can traverse the Golgi by a common mechanism without leaving the lumen of cisternae

    Alexander A. Mironov;Galina V. Beznoussenko;Paolo Nicoziani;Oliviano Martella

  • Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders.

    Alessandro Fraldi;Fabio Annunziata;Alessia Lombardi;Hermann-Josef Kaiser

  • Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis

    Elena V. Polishchuk;Assunta Merolla;Josef Lichtmannegger;Alessia Romano

Frequent Co-Authors

Alexander A. Mironov
Alexander A. Mironov University of Manchester
Alberto Luini
Alberto Luini National Research Council (CNR)
Maria Antonietta De Matteis
Maria Antonietta De Matteis University of Naples Federico II
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine
Vivek Malhotra
Vivek Malhotra Institució Catalana de Recerca i Estudis Avançats
Daniela Corda
Daniela Corda National Academies of Sciences, Engineering, and Medicine
Alberto Auricchio
Alberto Auricchio Telethon Institute Of Genetics And Medicine
Jennifer Lippincott-Schwartz
Jennifer Lippincott-Schwartz Howard Hughes Medical Institute
Giancarlo Parenti
Giancarlo Parenti University of Naples Federico II
Paolo Bonaldo
Paolo Bonaldo University of Padua

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