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Biology and Biochemistry

D-Index
59
Citations
10724
World Ranking
12719
National Ranking
987

Overview

R. A. John Challiss is affiliated with the University of Leicester in the United Kingdom. Their research primarily focuses on biochemistry, genetics, molecular biology, and neuroscience, with particular emphasis on molecular biology and cellular and molecular neuroscience.

The scientist's main topics of work include receptor mechanisms and signaling, neuroscience and neuropharmacology research, nicotinic acetylcholine receptors study, monoclonal and polyclonal antibodies research, neuropeptides and animal physiology, neuroinflammation and neurodegeneration mechanisms, and protein kinase regulation and GTPase signaling.

Significant publications by R. A. John Challiss cover various aspects of receptor biology and pharmacology. Some recent papers include:

  • Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs, 2020, Nature Chemical Biology
  • β1-adrenoceptor-stimulated lactate production in cultured astrocytes is predominantly glycogen-independent, 2020, Biochemical Pharmacology
  • Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1, 2023, IUPHAR/BPS Guide to Pharmacology CITE
  • Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2, 2021, IUPHAR/BPS Guide to Pharmacology CITE
  • Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3, 2021, IUPHAR/BPS Guide to Pharmacology CITE

Frequent publication venues for their work include:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • Biochemical Pharmacology
  • Nature Chemical Biology

Collaborations are a component of their research, working often with Sophie J. Bradley, Arthur Christopoulos, Andrew B. Tobin, N.J.M. Birdsall, and David A. Brown.

Best Publications

  • Neuronal Ca2+ stores : activation and function

    Peter B. Simpson;R.A. John Challiss;Stefan R. Nahorski

  • Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences

    Stefan R. Nahorski;C. Ian Ragan;R.A.John Challiss

  • Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: Effects of neurotransmitters and depolarization

    R.A. John Challiss;Ian H. Batty;Stefan R. Nahorski

  • Intracellular signalling. Receptor-specific messenger oscillations.

    Mark S. Nash;Kenneth W. Young;R. A. John Challiss;Stefan R. Nahorski

  • Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse.

    Joern R. Steinert;Cornelia Kopp-Scheinpflug;Claire Baker;R.A. John Challiss

  • Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells

    Gary B. Willars;Stefan R. Nahorski;R.A. John Challiss

  • Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay.

    R A J Challiss;E R Chilvers;A L Willcocks;S R Nahorski

  • Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca2+, phospholipase C and mitogen-activated protein kinase

    Jennifer L. Albert;John P. Boyle;Jonathan A. Roberts;R. A. John Challiss

  • Non-visual GRKs: are we seeing the whole picture?

    Jonathon M. Willets;R.A.John Challiss;Stefan R. Nahorski

  • Phosphorus-31 NMR magnetization-transfer measurements of ATP turnover during steady-state isometric muscle contraction in the rat hind limb in vivo

    K.M. Brindle;M.J. Blackledge;R.A.J. Challiss;G.K. Radda

  • Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma

    Amanda Sutcliffe;Fay Hollins;Edith Gomez;Ruth Saunders

  • The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats

    G. Dimitriadis;M. Parry-Billings;S. Bevan;B. Leighton

  • Determinants of Metabotropic Glutamate Receptor-5-mediated Ca2+ and Inositol 1,4,5-Trisphosphate Oscillation Frequency RECEPTOR DENSITY VERSUS AGONIST CONCENTRATION

    Mark S. Nash;Michael J. Schell;Peter J. Atkinson;Neil R. Johnston

  • Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slices.

    E D Kennedy;R A J Challiss;C I Ragan;S R Nahorski

  • New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor

    Robert A Wilcox;William U Primrose;Stefan R Nahorski;R.A.John Challiss

  • Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways.

    Sukhwinder Thandi;Jonathan L. Blank;R. A. John Challiss

  • Mechanisms Underlying the Neuronal Calcium Sensor-1-evoked Enhancement of Exocytosis in PC12 Cells

    Schuichi Koizumi;Patrizia Rosa;Gary B. Willars;R.A. John Challiss

  • The effect of prostaglandins E1, E2 and F2α and indomethacin on the sensitivity of glycolysis and glycogen synthesis to insulin in stripped soleus muscles of the rat

    B Leighton;L Budohoski;F J Lozeman;R A J Challiss

  • Substrate cycles: their role in improving sensitivity in metabolic control

    E.A. Newsholme;R.A.J. Challiss;B. Crabtree

  • G(q/11) and G(i/o) activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype.

    Elizabeth C Akam;R A John Challiss;Stefan R Nahorski

Frequent Co-Authors

Stefan R. Nahorski
Stefan R. Nahorski University of Leicester
Edwin R. Chilvers
Edwin R. Chilvers Imperial College London
Andrew B. Tobin
Andrew B. Tobin University of Glasgow
Ian D. Forsythe
Ian D. Forsythe University of Leicester
Jürgen Wess
Jürgen Wess National Institutes of Health
Mark A. Giembycz
Mark A. Giembycz University of Calgary
Christopher E. Brightling
Christopher E. Brightling University of Leicester
Martin D. Bootman
Martin D. Bootman The Open University
Richard M. Eglen
Richard M. Eglen Corning (United States)
Elizabeth Scarr
Elizabeth Scarr University of Melbourne

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