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Biology and Biochemistry

D-Index
60
Citations
11325
World Ranking
12083
National Ranking
5175

Overview

Miklós Sahin-Tóth is a researcher affiliated with the University of California, Los Angeles in the United States. Their work primarily spans the field of Medicine, with specific contributions to Surgery, Oncology, Genetics, Epidemiology, and Immunology. The main topics explored in their research include pancreatitis pathology and treatment, pancreatic and hepatic oncology research, pancreatic function and diabetes, gastrointestinal disorders and treatments, diabetes and associated disorders, pediatric hepatobiliary diseases and treatments, and liver disease diagnosis and treatment.

The scientist has contributed extensively to several notable publication venues. Frequent publication outlets include:

  • Pancreatology
  • Gastroenterology
  • Scientific Reports
  • Gut
  • American Journal of Physiology-Gastrointestinal and Liver Physiology

Miklós Sahin-Tóth has collaborated with multiple researchers in their field. Frequent co-authors are:

  • Alexandra Demcsák
  • Eszter Hegyi
  • Balázs Csaba Németh
  • Gergő Berke
  • Máté Sándor

Their recent publications cover significant topics related to pancreatitis and pancreatic diseases. Selected papers include:

  • "Lipotoxicity and Cytokine Storm in Severe Acute Pancreatitis and COVID-19," 2020, Gastroenterology
  • "International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club," 2020, Pancreatology
  • "Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis," 2021, Journal of Biological Chemistry
  • "Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice," 2020, Scientific Reports
  • "Channelopathy of the Pancreas Causes Chronic Pancreatitis," 2020, Gastroenterology

This body of work reveals focused engagement with pancreatic diseases, molecular mechanisms underlying pancreatitis, and related inflammatory responses, with research outputs published consistently in specialized journals.

Best Publications

  • Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.

    Jonas Rosendahl;Heiko Witt;Richárd Szmola;Eesh Bhatia

  • Cys-scanning mutagenesis: a novel approach to structure–function relationships in polytopic membrane proteins

    S. Frillingos;M. Sahin-Toth;Jianhua Wu;H. R. Kaback

  • The kamikaze approach to membrane transport

    H R Kaback;M Sahin-Tóth;A B Weinglass

  • Variants in CPA1 are strongly associated with early onset chronic pancreatitis

    Heiko Witt;Sebastian Beer;Jonas Rosendahl;Jian Min Chen;Jian Min Chen

  • A degradation-sensitive anionic trypsinogen ( PRSS2 ) variant protects against chronic pancreatitis

    Heiko Witt;Miklós Sahin-Tóth;Olfert Landt;Jian Min Chen

  • Genetics, Cell Biology, and Pathophysiology of Pancreatitis.

    Julia Mayerle;Julia Mayerle;Matthias Sendler;Eszter Hegyi;Georg Beyer

  • Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis

    Andrea Párniczky;Balázs Kui;Andrea Szentesi;Andrea Szentesi;Anita Balázs

  • Gain-of-Function Mutations Associated with Hereditary Pancreatitis Enhance Autoactivation of Human Cationic Trypsinogen

    Miklós Sahin-Tóth;Miklós Tóth

  • Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis

    József Maléth;Anita Balázs;Petra Pallagi;Zsolt Balla

  • Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: Identity with Rinderknecht's enzyme Y

    Richárd Szmola;Miklós Sahin-Tóth

  • Human Cationic Trypsinogen ROLE OF Asn-21 IN ZYMOGEN ACTIVATION AND IMPLICATIONS IN HEREDITARY PANCREATITIS

    Miklós Sahin-Tóth

  • Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.

    J. Matthias Löhr;J. Matthias Löhr;J. Matthias Löhr;Ralf Faissner;Dirk Koczan;Peter Bewerunge

  • Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen.

    Peter Simon;F. Ulrich Weiss;Miklós Sahin-Tóth;Marina Parry

  • Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors.

    Richárd Szmola;Zoltán Kukor;Miklós Sahin-Tóth

  • Functional interactions between putative intramembrane charged residues in the lactose permease of Escherichia coli.

    M Sahin-Tóth;R L Dunten;A Gonzalez;H R Kaback

  • Hereditary pancreatitis caused by mutation induced misfolding of human cationic trypsinogen - a novel disease mechanism

    Éva Kereszturi;Richárd Szmola;Zoltán Kukor;Peter Simon

  • Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli.

    M Sahin-Tóth;M C Lawrence;H R Kaback

  • Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway

    Eszter Hegyi;Miklós Sahin-Tóth

  • Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis.

    Niels Teich;Jonas Rosendahl;Miklós Tóth;Joachim Mössner

  • Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

    Thomas Wartmann;Julia Mayerle;Thilo Kähne;Miklós Sahin–Tóth

Frequent Co-Authors

Markus M. Lerch
Markus M. Lerch Greifswald University Hospital
H. Ronald Kaback
H. Ronald Kaback University of California, Los Angeles
Joachim Mössner
Joachim Mössner Leipzig University
Jian-Min Chen
Jian-Min Chen University of Western Brittany
Claude Férec
Claude Férec University of Western Brittany
Julia Mayerle
Julia Mayerle Ludwig-Maximilians-Universität München
Michael Stumvoll
Michael Stumvoll Leipzig University
John P. Neoptolemos
John P. Neoptolemos Heidelberg University
Ole H. Petersen
Ole H. Petersen Cardiff University
Peter Kovacs
Peter Kovacs Leipzig University

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