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Biology and Biochemistry

D-Index
62
Citations
14389
World Ranking
10751
National Ranking
208

Overview

Miguel A. del Pozo is affiliated with the Spanish National Centre for Cardiovascular Research in Spain. Their research spans the intersection of biochemistry, genetics, molecular biology, and medicine, with a strong focus on cell biology and molecular processes. The scientist has published extensively on topics related to cellular mechanics, signaling pathways, and membrane dynamics.

Their work frequently addresses the role of Caveolin-1 and associated cellular processes, cellular mechanics and interactions, and the Hippo pathway signaling with YAP/TAZ. Additional research topics include endoplasmic reticulum stress and disease, erythrocyte function and pathophysiology, cell adhesion molecules, as well as microtubule and mitosis dynamics.

  • Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense (2020, Science)
  • ECM deposition is driven by caveolin-1-dependent regulation of exosomal biogenesis and cargo sorting (2020, The Journal of Cell Biology)
  • Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation (2020, Current Opinion in Cell Biology)
  • Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP (2022, Nature Communications)
  • Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis (2020, Cell Death and Disease)

The scientist has collaborated frequently with a core group of coauthors, including Miguel Sánchez-Álvarez, Fidel-Nicolás Lolo, Jesús Vázquez, Víctor Jiménez-Jiménez, and Pere Roca-Cusachs. This network underscores a consistent research collaboration within their field.

Publication venues where their research appears regularly include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, eLife, The Journal of Cell Biology, and Cells. This indicates engagement with peer-reviewed journals relevant to molecular and cellular biology communities.

Miguel A. del Pozo's primary fields of study reflect a combination of fundamental and applied biomedical sciences. Specifically, their work intersects the following areas:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields where they have published most extensively include:

  • Cell Biology
  • Molecular Biology
  • Cancer Research
  • Physiology
  • Immunology and Allergy

Key scientific topics explored involve:

  • Caveolin-1 and cellular processes
  • Cellular Mechanics and Interactions
  • Hippo pathway signaling and YAP/TAZ
  • Endoplasmic Reticulum Stress and Disease
  • Erythrocyte Function and Pathophysiology
  • Cell Adhesion Molecules Research
  • Microtubule and mitosis dynamics

Best Publications

  • Caveolae as plasma membrane sensors, protectors and organizers

    Robert G. Parton;Miguel A. del Pozo

  • Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

    Jacky G. Goetz;Susana Minguet;Inmaculada Navarro-Lérida;Juan José Lazcano

  • Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.

    Eleni Tzima;Miguel Angel del Pozo;Sanford J. Shattil;Shu Chien

  • Integrins regulate Rac targeting by internalization of membrane domains.

    Miguel A. del Pozo;Miguel A. del Pozo;Nazilla B. Alderson;William B. Kiosses;Hui-Hsien Chiang

  • Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

    Miguel A del Pozo;Leo S Price;Nazilla B Alderson;Xiang‐Dong Ren

  • Overcoming anoikis – pathways to anchorage-independent growth in cancer

    Marta C. Guadamillas;Ana Cerezo;Miguel A. del Pozo

  • Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization

    Miguel A. del Pozo;Nagaraj Balasubramanian;Nazilla B. Alderson;William B. Kiosses

  • Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

    Marta Bosch;Miguel Sánchez-Álvarez;Alba Fajardo;Ronan Kapetanovic

  • Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression

    Eleni Tzima;Miguel Angel Del Pozo;William B. Kiosses;Samih A. Mohamed

  • Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases.

    Araceli Grande-García;Asier Echarri;Johan de Rooij;Nazilla B. Alderson

  • Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.

    M A del Pozo;P Sánchez-Mateos;M Nieto;F Sánchez-Madrid

  • Effects of cell tension on the small GTPase Rac

    Akira Katsumi;Julie Milanini;William B. Kiosses;Miguel A. del Pozo

  • Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization.

    Juan M. Serrador;José L. Alonso-Lebrero;Miguel A. del Pozo;Heinz Furthmayr

  • Caveolae – mechanosensitive membrane invaginations linked to actin filaments

    Asier Echarri;Miguel A. Del Pozo

  • A palmitoylation switch mechanism regulates Rac1 function and membrane organization

    Inmaculada Navarro-Lérida;Sara Sánchez-Perales;María Calvo;Carles Rentero

  • Localized Cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress

    Eleni Tzima;William B. Kiosses;Miguel A. del Pozo;Martin Alexander Schwartz

  • Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs

    F Díaz-González;I González-Alvaro;M R Campanero;F Mollinedo

  • ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway.

    M R Campanero;M A del Pozo;A G Arroyo;P Sánchez-Mateos

  • Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe

    L. Marije Hofstra;Nicolas Sauvageot;Jan Albert;Jan Albert;Ivailo Alexiev

  • Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

    Aleix Sala-Vila;Aleix Sala-Vila;Inmaculada Navarro-Lerida;Miguel Sanchez-Alvarez;Marta Bosch

Frequent Co-Authors

Robert G. Parton
Robert G. Parton University of Queensland
Jesús Vázquez
Jesús Vázquez Spanish National Centre for Cardiovascular Research
Francisco Sánchez-Madrid
Francisco Sánchez-Madrid Autonomous University of Madrid
Manuel López-Cabrera
Manuel López-Cabrera Spanish National Research Council
Juan Antonio López
Juan Antonio López Spanish National Centre for Cardiovascular Research
Jesús Balsinde
Jesús Balsinde Spanish National Research Council
Albert Pol
Albert Pol Institució Catalana de Recerca i Estudis Avançats
Paloma Sánchez-Mateos
Paloma Sánchez-Mateos Hospital General Universitario Gregorio Marañón
Satyajit Mayor
Satyajit Mayor National Centre for Biological Sciences
Olli Kallioniemi
Olli Kallioniemi Karolinska Institute

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