World's Best Scientists 2026 revealed!

Research.com Recognitions

  • 2007 - National Institutes of Health Director's Pioneer Award
  • Member of the Association of American Physicians

Overview

Marshall S. Horwitz was affiliated with the Albert Einstein College of Medicine in the United States. Their research focused extensively on several fields within biochemistry, genetics, molecular biology, and medicine.

The scientist's work covered various subfields such as molecular biology, genetics, hematology, immunology, and physiology. The main topics of study included blood disorders and treatments, acute myeloid leukemia research, myeloproliferative neoplasms diagnosis and treatment, single-cell and spatial transcriptomics, erythrocyte function and pathophysiology, RNA research and splicing, as well as CRISPR and genetic engineering.

Marshall S. Horwitz contributed to numerous publications, some of the most cited being:

  • RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML, 2020, Blood Advances
  • Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response, 2020, Journal of Biological Chemistry
  • Restoring RUNX1 deficiency in RUNX1 familial platelet disorder by inhibiting its degradation, 2021, Blood Advances
  • Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical development, 2022, Cell Systems
  • Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1 -familial platelet disorder, 2025, Science Translational Medicine

The frequent coauthors who collaborated with Marshall S. Horwitz included:

  • Sioḃán Keel
  • Lucy A. Godley
  • Donovan J. Anderson
  • Hsin-Yun Lin
  • Erica Bresciani

Publications were often featured in venues such as:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood Advances
  • Journal of Biological Chemistry
  • Science Translational Medicine

Marshall S. Horwitz received the National Institutes of Health Director's Pioneer Award in 2007. They were also a member of the Association of American Physicians. The profile of their career reflects extensive research output and collaboration within the fields of hematology, molecular biology, and genetics until their passing.

Best Publications

  • Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

    Jeffrey M. Bergelson;Jennifer A. Cunningham;Gustavo Droguett;Evelyn A. Kurt-Jones

  • Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

    Brice Korkmaz;Marshall S. Horwitz;Dieter E. Jenne;Francis Gauthier

  • Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.

    David C. Dale;Richard E. Person;Audrey Anna Bolyard;Andrew G. Aprikyan

  • Whole-organism lineage tracing by combinatorial and cumulative genome editing

    Aaron McKenna;Gregory M. Findlay;James A. Gagnon;Marshall S. Horwitz

  • Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

    Christopher N. Hahn;Christopher N. Hahn;Chan-Eng Chong;Chan-Eng Chong;Catherine L. Carmichael;Ella J. Wilkins;Ella J. Wilkins

  • HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC‐to‐EpiSC/hESC transition

    Wenyu Zhou;Michael Choi;Daciana Margineantu;Lilyana Margaretha

  • HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

    Julie Mathieu;Zhan Zhang;Wenyu Zhou;Amy J. Wang

  • The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses

    Jeffrey M. Bergelson;Anita Krithivas;Leo Celi;Gustavo Droguett

  • DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.

    Tal Raveh;Gustavo Droguett;Marshall S. Horwitz;Ronald A. DePinho

  • Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2.

    Richard E. Person;Feng Qian Li;Zhijun Duan;Kathleen F. Benson

  • The impact of adenovirus infection on the immunocompromised host

    Tsoline Kojaoghlanian;Phyllis Flomenberg;Marshall S. Horwitz;Marshall S. Horwitz

  • Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy

    Michael Y. Zhang;Jane E. Churpek;Siobán B. Keel;Tom Walsh

  • A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

    Sohela Shah;Kasmintan A. Schrader;Esmé Waanders;Andrew E. Timms

  • Interaction of an Adenovirus E3 14.7-kilodalton Protein With a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains

    Yongan Li;Jian Kang;Marshall S. Horwitz

  • Neutrophil elastase in cyclic and severe congenital neutropenia

    Marshall S. Horwitz;Zhijun Duan;Brice Korkmaz;Hu Hui Lee

  • Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature

    Jan Kazenwadel;Genevieve A. Secker;Yajuan J. Liu;Jill A. Rosenfeld

  • Biliary Atresia and Reovirus Type 3 Infection

    Rachel Morecki;Joy H. Glaser;Sangho Cho;William F. Balistreri

  • Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.

    Yongan Li;Jian Kang;Joshua Friedman;Leonid Tarassishin

  • Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression.

    Yaron Ilan;Gustavo Droguett;Namita Roy Chowdhury;Yongan Li

  • Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.

    Zhijun Duan;Adrian Zarebski;Diego Montoya-Durango;H. Leighton Grimes

Frequent Co-Authors

David Wallach
David Wallach Weizmann Institute of Science
Susan Band Horwitz
Susan Band Horwitz Albert Einstein College of Medicine
Kyosuke Nagata
Kyosuke Nagata University of Tsukuba
Robert W. Finberg
Robert W. Finberg University of Massachusetts Chan Medical School
Jeffrey M. Bergelson
Jeffrey M. Bergelson Children's Hospital of Philadelphia
Howard J. Federoff
Howard J. Federoff University of California, Irvine
Julian L. Leibowitz
Julian L. Leibowitz Texas A&M University
Christopher F. Basler
Christopher F. Basler University of Georgia
Jeffrey Field
Jeffrey Field University of Pennsylvania
Antonia Follenzi
Antonia Follenzi University of Eastern Piedmont Amadeo Avogadro

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