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Mark S. Freedman

Mark S. Freedman

D-Index & Metrics

Medicine

D-Index
92
Citations
44112
World Ranking
11103
National Ranking
445

Overview

Mark S. Freedman is affiliated with the Ottawa Hospital in Canada and has contributed extensively to the field of medicine, with a particular focus on multiple sclerosis research studies.

Their research spans several subfields including pathology and forensic medicine, neurology, oncology, public health, environmental and occupational health, and rheumatology.

Themes prevalent in their work include multiple sclerosis research studies, peripheral neuropathies and disorders, acute lymphoblastic leukemia research, systemic sclerosis and related diseases, systemic lupus erythematosus research, polyomavirus and related diseases, and cytokine signaling pathways and interactions.

Freedman has frequently collaborated with several prominent co-authors in the field. These include:

  • Xavier Montalbán
  • Ludwig Kappos
  • Frederik Barkhof
  • Nicola De Stefano
  • Fred Lublin

Their publications have appeared predominantly in the following scientific venues:

  • Multiple Sclerosis Journal
  • Multiple Sclerosis and Related Disorders
  • NeuroImage Clinical
  • JAMA Neurology
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Among the recent papers featuring Mark S. Freedman as author or co-author are:

  • "Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study," 2021, JAMA Neurology
  • "Treatment Optimization in Multiple Sclerosis: Canadian MS Working Group Recommendations," 2020, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • "Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria," 2025, The Lancet Neurology
  • "Long-term follow-up of patients with relapsing multiple sclerosis from the CLARITY/CLARITY Extension cohort of CLASSIC-MS: An ambispective study," 2023, Multiple Sclerosis Journal
  • "Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder - recommendations from ECTRIMS and the EBMT," 2025, Nature Reviews Neurology

Best Publications

  • Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

    Alan J. Thompson;Brenda L. Banwell;Frederik Barkhof;Frederik Barkhof;William M. Carroll

  • Defining the clinical course of multiple sclerosis: The 2013 revisions

    Fred D. Lublin;Stephen C. Reingold;Jeffrey A. Cohen;Gary R. Cutter

  • Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis

    Paul O'Connor;Jerry S Wolinsky;Christian Confavreux;Giancarlo Comi

  • Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial†

    Kathleen Hawker;Paul O'Connor;Mark S. Freedman;Peter A. Calabresi

  • Differential diagnosis of suspected multiple sclerosis: a consensus approach

    D. H. Miller;B. G. Weinshenker;M. Filippi;B. L. Banwell

  • Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes

    L. Kappos;C.H. Polman;M.S. Freedman;G. Edan

  • A full genome search in multiple sclerosis

    G C Ebers;K Kukay;D E Bulman;A D Sadovnick

  • Quantifying axonal loss after optic neuritis with optical coherence tomography.

    Fiona Costello;Stuart Coupland;William Hodge;Gianni R. Lorello

  • Recommended Standard of Cerebrospinal Fluid Analysis in the Diagnosis of Multiple Sclerosis: A Consensus Statement

    Mark S. Freedman;Edward J. Thompson;Florian Deisenhammer;Gavin Giovannoni

  • Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis

    Martin Duddy;Masaaki Niino;Femina Adatia;Sherry Hebert

  • Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial.

    Christian Confavreux;Paul O'Connor;Giancarlo Comi;Mark S. Freedman

  • Vitamin D as an early predictor of multiple sclerosis activity and progression.

    Alberto Ascherio;Kassandra L. Munger;Rick White;Karl Köchert

  • Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study

    Ludwig Kappos;Mark S Freedman;Chris H Polman;Gilles Edan

  • Glatiramer acetate in primary progressive multiple sclerosis: Results of a multinational, multicenter, double-blind, placebo-controlled trial

    Jerry S. Wolinsky;Ponnada A. Narayana;Paul O'Connor;Patricia K. Coyle

  • Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial

    Fred Lublin;David H Miller;Mark S Freedman;Bruce A C Cree

  • Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

    Kevin C O'Connor;Katherine A McLaughlin;Philip L De Jager;Tanuja Chitnis;Tanuja Chitnis

  • A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses

    P W O'Connor;D Li;M S Freedman;A Bar-Or

  • Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study

    Brenda Banwell;Lauren Krupp;Julia Kennedy;Raymond Tellier

  • Recommended Standard of Cerebrospinal Fluid Analysis in the Diagnosis of Multiple Sclerosis

    Mark S. Freedman;Edward J. Thompson;Florian Deisenhammer;Gavin Giovannoni

  • Quantifying axonal loss after optic neuritis with optical coherence tomography

    F. Costello;S. Coupland;W. Hodge;G.R. Lorello

Frequent Co-Authors

Ludwig Kappos
Ludwig Kappos University Hospital of Basel
Giancarlo Comi
Giancarlo Comi Vita-Salute San Raffaele University
Xavier Montalban
Xavier Montalban Autonomous University of Barcelona
Jerry S. Wolinsky
Jerry S. Wolinsky The University of Texas Health Science Center at Houston
Frederik Barkhof
Frederik Barkhof University College London
Hans-Peter Hartung
Hans-Peter Hartung Heinrich Heine University Düsseldorf
Tomas Olsson
Tomas Olsson Karolinska Institute
Chris H. Polman
Chris H. Polman VU University Medical Center
Amit Bar-Or
Amit Bar-Or University of Pennsylvania
Douglas L. Arnold
Douglas L. Arnold Montreal Neurological Institute and Hospital

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