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Biology and Biochemistry

D-Index
44
Citations
8630
World Ranking
19250
National Ranking
1312

Overview

Klaus Ebnet is affiliated with the University of Münster in Germany and has a research focus primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans multiple subfields including Cell Biology, Molecular Biology, Immunology and Allergy, Neurology, and Immunology. The scientist has published extensively on topics such as Cell Adhesion Molecules Research, Hippo pathway signaling and YAP/TAZ, Cellular Mechanics and Interactions, Wnt/β-catenin signaling in development and cancer, Barrier Structure and Function Studies, Platelet Disorders and Treatments, and Caveolin-1 and cellular processes.

Their recent publications highlight interdisciplinary research addressing cellular and molecular mechanisms. Notable papers include:

  • Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly, 2020, Cell Reports
  • Physiological functions of junctional adhesion molecules (JAMs) in tight junctions, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Tetraspanins: integrating cell surface receptors to functional microdomains in homeostasis and disease, 2020, Medical Microbiology and Immunology
  • Cell Adhesion at the Tight Junctions: New Aspects and New Functions, 2023, Cells
  • Functional multi-organelle units control inflammatory lipid metabolism of macrophages, 2024, Nature Cell Biology

Klaus Ebnet frequently collaborates with several coauthors who have contributed significantly to their research output. These include Volker Gerke, Christian Hartmann, Mariel Flavia Schwietzer, Sonja Thölmann, and Eva-Maria Thüring.

In terms of publication venues, their work has appeared in journals such as bioRxiv (Cold Spring Harbor Laboratory), Cellular and Molecular Life Sciences, Frontiers in Cell and Developmental Biology, Cell Reports, and Biochimica et Biophysica Acta (BBA) - Biomembranes.

Best Publications

  • Junctional adhesion molecules (JAMs): more molecules with dual functions?

    Klaus Ebnet;Atsushi Suzuki;Shigeo Ohno;Dietmar Vestweber;Dietmar Vestweber

  • Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1

    Klaus Ebnet;Christian U. Schulz;Maria-Katharina Meyer zu Brickwedde;Gunther G. Pendl

  • The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM).

    Klaus Ebnet;Atsushi Suzuki;Yosuke Horikoshi;Tomonori Hirose

  • Molecular mechanisms that control leukocyte extravasation: the selectins and the chemokines.

    Klaus Ebnet;Dietmar Vestweber

  • The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity

    Klaus Ebnet;Michel Aurrand-Lions;Annegret Kuhn;Friedemann Kiefer

  • aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization

    Atsushi Suzuki;Chikako Ishiyama;Katsutaka Hashiba;Miki Shimizu

  • Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C

    Georgia Gliki;Klaus Ebnet;Michel Aurrand-Lions;Beat A. Imhof

  • A transmembrane tight junction protein selectively expressed on endothelial cells and platelets

    Ines Nasdala;Karen Wolburg-Buchholz;Karen Wolburg-Buchholz;Hartwig Wolburg;Annegret Kuhn

  • In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

    Markus M. Simon;Michael Hausmann;Thao Tran;Klaus Ebnet

  • miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.

    M Götte;C Mohr;C-Y Koo;C Stock

  • Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

    Ebnet K;Hausmann M;Lehmann-Grube F;Müllbacher A

  • Orchestrated information transfer underlying leukocyte endothelial interactions.

    Klaus Ebnet;Eric P. Kaldjian;Arthur O. Anderson;Stephen Shaw

  • Organization of multiprotein complexes at cell–cell junctions

    Klaus Ebnet

  • The Borrelia burgdorferi flagellum-associated 41-kilodalton antigen (flagellin): molecular cloning, expression, and amplification of the gene.

    R Wallich;S E Moter;M M Simon;K Ebnet

  • Borrelia burgdorferi activates nuclear factor-kappa B and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts.

    K Ebnet;K D Brown;U K Siebenlist;M M Simon

  • Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

    Tetsuhisa Otani;Thanh Phuong Nguyen;Shinsaku Tokuda;Kei Sugihara

  • Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

    Arno Mullbacher;Klaus Ebnet;Robert V. Blanden;Ron Tha Hla

  • Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development

    Klaus Ebnet

  • Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

    Julian Pardo;R Wallich;K Ebnet;S Iden

  • Association of Csk to VE-cadherin and inhibition of cell proliferation

    Ulf Baumeister;Ruth Funke;Klaus Ebnet;Henrik Vorschmitt

Frequent Co-Authors

Dietmar Vestweber
Dietmar Vestweber Max Planck Society
Markus M. Simon
Markus M. Simon Max Planck Society
Volker Gerke
Volker Gerke University of Münster
Atsushi Suzuki
Atsushi Suzuki Yokohama City University
Shigeo Ohno
Shigeo Ohno Yokohama City University
Michel Aurrand-Lions
Michel Aurrand-Lions Aix-Marseille University
Stephen Shaw
Stephen Shaw National Institutes of Health
Beat A. Imhof
Beat A. Imhof University of Geneva
Hartwig Wolburg
Hartwig Wolburg University of Tübingen
Reinhard Wallich
Reinhard Wallich Heidelberg University

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