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Genetics

D-Index
53
Citations
33259
World Ranking
3676
National Ranking
1594

Overview

Kasper Lage is affiliated with Harvard University in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a particular focus on molecular biology, genetics, neurology, cellular and molecular neuroscience, and cancer research.

The scientist's work covers a range of topics including:

  • Bioinformatics and Genomic Networks
  • Genetic Associations and Epidemiology
  • CRISPR and Genetic Engineering
  • Single-cell and spatial transcriptomics
  • RNA Interference and Gene Delivery
  • Virus-based gene therapy research
  • Genomics and Chromatin Dynamics

Kasper Lage has published extensively, contributing to notable scientific journals and preprint servers. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Systems
  • Nature Communications
  • European Neuropsychopharmacology
  • Nature

Some recent papers authored or co-authored by Kasper Lage are:

  • "Autism genes converge on asynchronous development of shared neuron classes," 2022, Nature
  • "Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases," 2023, Nature Genetics
  • "Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants," 2020, Proceedings of the National Academy of Sciences
  • "Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility," 2021, Nature Neuroscience

The scientist collaborates frequently with a group of co-authors, including:

  • Greta Pintacuda
  • Yu-Han H. Hsu
  • Nadine Fornelos
  • Edyta Małolepsza
  • Kalliopi Tsafou

Best Publications

  • A global reference for human genetic variation.

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

  • A human phenome-interactome network of protein complexes implicated in genetic disorders

    Kasper Lage;E Olof Karlberg;Zenia M Størling;Páll Í Ólason

  • A global reference for human genetic variation

    Adam Auton;Gonçalo R. Abecasis;David M. Altshuler;Richard M. Durbin

  • Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

    Michael E. Talkowski;Jill A. Rosenfeld;Ian Blumenthal;Vamsee Pillalamarri

  • Pervasive sharing of genetic effects in autoimmune disease.

    Chris Cotsapas;Benjamin F. Voight;Benjamin F. Voight;Elizabeth Rossin;Kasper Lage;Kasper Lage;Kasper Lage

  • Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns

    Alicia Lundby;Kasper Lage;Brian T. Weinert;Dorte B. Bekker-Jensen

  • A scored human protein–protein interaction network to catalyze genomic interpretation

    Taibo Li;Rasmus Wernersson;Rasmus B Hansen;Heiko Horn;Heiko Horn

  • Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

    Elizabeth J. Rossin;Kasper Lage;Soumya Raychaudhuri;Soumya Raychaudhuri;Soumya Raychaudhuri;Ramnik J. Xavier;Ramnik J. Xavier

  • Genome-wide meta-analysis identifies new susceptibility loci for migraine

    Verneri Anttila;Bendik S. Winsvold;Bendik S. Winsvold;Padhraig Gormley;Tobias Kurth

  • An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

    Catherine A. Brownstein;Alan H. Beggs;Nils Homer;Barry Merriman

  • Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics

    Ekta Khurana;Yao Fu;Vincenza Colonna;Vincenza Colonna;Xinmeng Jasmine Mu

  • Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues

    Alicia Lundby;Anna Secher;Anna Secher;Kasper Lage;Nikolai B. Nordsborg

  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Dan E. Arking;Sara L. Pulit;Sara L. Pulit;Sara L. Pulit;Lia Crotti;Pim Van Der Harst

  • A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes

    Kasper Lage;Niclas Tue Hansen;E. Olof Karlberg;Aron C. Eklund

  • Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism

    Hichem Miraoui;Andrew A. Dwyer;Andrew A. Dwyer;Gerasimos P. Sykiotis;Gerasimos P. Sykiotis;Lacey Plummer

  • Assessment of network module identification across complex diseases.

    Sarvenaz Choobdar;Mehmet E Ahsen;Jake Crawford;Mattia Tomasoni;Mattia Tomasoni

  • Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination

    David H. Margolin;Maria Kousi;Yee-Ming Chan;Elaine T. Lim

  • Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

    Brigit E. Riley;Stephen E. Kaiser;Thomas A. Shaler;Aylwin C.Y. Ng;Aylwin C.Y. Ng

  • Comprehensive assessment of cancer missense mutation clustering in protein structures

    Atanas Kamburov;Michael S. Lawrence;Paz Polak;Ignaty Leshchiner

  • Pervasive Sharing of Genetic Effects in Autoimmune Disease

    Chris Cotsapas;Benjamin F. Voight;Elizabeth Rossin;Kasper Lage

Frequent Co-Authors

Mark J. Daly
Mark J. Daly Massachusetts General Hospital
Søren Brunak
Søren Brunak University of Copenhagen
Patricia K. Donahoe
Patricia K. Donahoe Harvard University
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
Tune H. Pers
Tune H. Pers University of Copenhagen
Aarno Palotie
Aarno Palotie University of Helsinki
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Flemming Pociot
Flemming Pociot Steno Diabetes Center
Paul I. W. de Bakker
Paul I. W. de Bakker Vertex Pharmaceuticals (United Kingdom)

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