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Biology and Biochemistry

D-Index
70
Citations
18343
World Ranking
6981
National Ranking
3211

Overview

John A. Frangos is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. These areas reflect a focus on understanding biological processes and immune system mechanisms.

The scientist's work delves into several specialized subfields, including Hematology, Immunology, and Cell Biology. These subfields align with their focus on blood-related medical studies, immune system function, and cellular mechanisms.

Core research topics addressed by John A. Frangos encompass:

  • Hematopoietic Stem Cell Transplantation
  • Immune cells in cancer
  • Zebrafish Biomedical Research Applications

Among recent publications, one notable paper is titled "Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance", published in 2025 in the journal Nature. This research contributes to the understanding of bone marrow environments in regulating stem cell behavior and immune response.

John A. Frangos has collaborated with several frequent co-authors, indicating multidisciplinary and team-based research approaches. These collaborators include:

  • Kazuhiro Furuhashi
  • Miwako Kakiuchi
  • Ryosuke Ueda
  • Hiroko Oda
  • Simone Ummarino

The scientist's work has appeared notably in the venue Nature, which is also the publisher of their recent highlighted paper.

Best Publications

  • Flow effects on prostacyclin production by cultured human endothelial cells.

    John A. Frangos;Suzanne G. Eskin;Larry V. McIntire;C. L. Ives

  • Sensitivity of osteocytes to biomechanical stress in vitro.

    J Klein-Nulend;A van der Plas;C M Semeins;N E Ajubi

  • Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells

    M. J. Kuchan;J. A. Frangos

  • Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells.

    M. J. Kuchan;J. A. Frangos

  • G protein-coupled receptors sense fluid shear stress in endothelial cells

    Mirianas Chachisvilis;Yan-Liang Zhang;John A. Frangos

  • Shear stress induced stimulation of mammalian cell metabolism

    J. A. Frangos;L. V. McIntire;S. G. Eskin

  • Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production.

    Kathleen M. Reich;John A. Frangos

  • Liver Sinusoidal Endothelial Cells Are Responsible for Nitric Oxide Modulation of Resistance in the Hepatic Sinusoids

    Vijay Shah;Fadi G. Haddad;Fadi G. Haddad;Guillermo Garcia-Cardena;John A. Frangos

  • Modulation of GTPase Activity of G Proteins by Fluid Shear Stress and Phospholipid Composition

    Sivaramaprasad Gudi;John P. Nolan;John A. Frangos

  • Fluid Flow Rapidly Activates G Proteins in Human Endothelial Cells: Involvement of G Proteins in Mechanochemical Signal Transduction

    Siva R.P. Gudi;Craig B. Clark;John A. Frangos

  • Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts

    K. M. Reich;J. A. Frangos

  • Shear stress increases endothelial platelet-derived growth factor mRNA levels

    H. J. Hsieh;N. Q. Li;J. A. Frangos

  • Bone tissue engineering: the role of interstitial fluid flow.

    M. V. Hillsley;J. A. Frangos

  • The shear stress of it all: the cell membrane and mechanochemical transduction.

    Charles R White;John A Frangos

  • Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells.

    M. J. Kuchan;Hanjoong Jo;J. A. Frangos

  • Temporal Gradient in Shear But Not Steady Shear Stress Induces PDGF-A and MCP-1 Expression in Endothelial Cells Role of NO, NFκB, and egr-1

    Xuping Bao;Chuanyi Lu;John A. Frangos

  • Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts

    Dameron L. Johnson;Todd N. McAllister;John A. Frangos

  • Pulsatile and steady flow induces c-fos expression in human endothelial cells.

    Hsyue-Jen Hsieh;Nan-Qian Li;John A. Frangos

  • Fluid shear stress increases membrane fluidity in endothelial cells : a study with DCVJ fluorescence

    Mark A. Haidekker;Nicolas L'Heureux;John A. Frangos

  • Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways

    T. N. McAllister;J. A. Frangos

Frequent Co-Authors

Marcos Intaglietta
Marcos Intaglietta University of California, San Diego
Joanna McKittrick
Joanna McKittrick University of California, San Diego
Larry V. McIntire
Larry V. McIntire Georgia Institute of Technology
Emmanuel A. Theodorakis
Emmanuel A. Theodorakis University of California, San Diego
Peter F. Davies
Peter F. Davies University of Pennsylvania
Roberto J. Groszmann
Roberto J. Groszmann Yale University
Edwin E. Daniel
Edwin E. Daniel University of Alberta
Akos Koller
Akos Koller New York Medical College
Geoffrey Burnstock
Geoffrey Burnstock University College London
Richard N. Arteca
Richard N. Arteca Pennsylvania State University

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