Juan Carlos Lacal

Overview

Best Publications

• Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

  R Perona;S Montaner;L Saniger;I Sánchez-Pérez

  805
  Citations

• Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

  Ana Ramı́rez de Molina;Agustı́n Rodrı́guez-González;Ruth Gutiérrez;Luis Martı́nez-Piñeiro

  416
  Citations

• Rho signals to cell growth and apoptosis.

  Salvador Aznar;Juan Carlos Lacal

  406
  Citations

• Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha- ras oncogene

  Juan Carlos Lacal;Jorge Moscat;Stuart A. Aaronson

  361
  Citations

• Rho GTPase expression in tumourigenesis: evidence for a significant link.

  Teresa Gómez del Pulgar;Salvador A. Benitah;Pilar F. Valerón;Carolina Espina

  325
  Citations

• Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.

  Ana Ramírez de Molina;Ruth Gutiérrez;Maria Angeles Ramos;José María Silva

  307
  Citations

• Multiple signalling pathways lead to the activation of the nuclear factor κB by the Rho family of GTPases

  Silvia Montaner;Rosario Perona;Luisa Saniger;Juan Carlos Lacal

  303
  Citations

• Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.

  Antonio Cuadrado;Amancio Carnero;F. Dolfi;Benilde Jiménez

  226
  Citations

• Choline kinase inhibitors as a novel approach for antiproliferative drug design

  R Hernández-Alcoceba;L Saniger;J Campos;M C Núñez

  218
  Citations

• Rho proteins induce metastatic properties in vivo.

  del Peso L;del Peso L;Hernández-Alcoceba R;Embade N;Carnero A

  216
  Citations

• Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.

  María Virtudes Céspedes;Carolina Espina;Miguel Angel García-Cabezas;Miguel Angel García-Cabezas;Manuel Trias

  213
  Citations

• A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

  E G Lapetina;J C Lacal;B R Reep;L Molina y Vedia

  199
  Citations

• Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation.

  Salvador A. Benitah;Pilar F. Valerón;Linda van Aelst;Christopher J. Marshall

  192
  Citations

• Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study

  Ana Ramírez de Molina;Jacinto Sarmentero-Estrada;Cristóbal Belda-Iniesta;Cristóbal Belda-Iniesta;Miquel Tarón

  188
  Citations

• Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.

  Ana Ramírez de Molina;Mónica Báñez-Coronel;Ruth Gutiérrez;Agustín Rodríguez-González

  182
  Citations

• In Vivo Antitumor Activity of Choline Kinase Inhibitors: A Novel Target for Anticancer Drug Discovery

  Rubén Hernández-Alcoceba;Félix Fernández;Juan Carlos Lacal

  182
  Citations

• Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

  Nada M.S. Al-Saffar;Helen Troy;Ana Ramírez de Molina;Laura E. Jackson

  178
  Citations

• Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.

  Elsa Sanchez-Lopez;Zhenyu Zhong;Zhenyu Zhong;Alexandra Stubelius;Shannon R. Sweeney

  175
  Citations

• Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H-ras p21

  JC Lacal;P de la Pena;J Moscat;P Garcia-Barreno

  169
  Citations

• Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

  J C Lacal;T P Fleming;B S Warren;P M Blumberg

  160
  Citations