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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
12405
World Ranking
9340
National Ranking
172

Juan Carlos Lacal publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Juan Carlos Lacal sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 192 publications — 46th percentile

46% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Juan Carlos Lacal D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Juan Carlos Lacal sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 65 D-Index — 55th percentile

55% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Juan Carlos Lacal is affiliated with the Spanish National Research Council in Spain and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans multiple subfields including molecular biology, biomedical engineering, epidemiology, ophthalmology, and biomaterials.

Their work covers several main topics such as:

  • Protein Kinase Regulation and GTPase Signaling
  • Biochemical and Molecular Research
  • Drug-Induced Ocular Toxicity
  • Ultrasound and Hyperthermia Applications
  • Nanoparticle-Based Drug Delivery
  • 3D Printing in Biomedical Research
  • Hippo pathway signaling and YAP/TAZ

Juan Carlos Lacal has published research in several scientific venues, with the highest frequency in:

  • Pharmaceutics
  • British Journal of Cancer
  • Frontiers in Endocrinology
  • ACS Applied Materials & Interfaces
  • Scientific Reports

Notable recent papers include:

  • Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases (2021, Pharmaceutics)
  • Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells (2024, British Journal of Cancer)
  • Preclinical Development of Magnetic Nanoparticles for Hyperthermia Treatment of Pancreatic Cancer (2025, ACS Applied Materials & Interfaces)
  • Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae (2020, Scientific Reports)
  • Choline Kinase α Inhibitors MN58b and RSM932A Enhances the Antitumor Response to Cisplatin in Lung Tumor Cells (2022, Pharmaceutics)

The scientist has frequently collaborated with colleagues such as Tahl Zimmerman, Arancha Cebrián, Salam A. Ibrahim, Anxo Río-Vilariño, and Aiora Cenigaonandia-Campillo. The collaborations highlight ongoing multidisciplinary cooperation within the biomedical research community.

Juan Carlos Lacal's work contributes to understanding molecular mechanisms and developing therapeutic strategies related to protein kinase regulation, drug resistance in cancer therapies, nanoparticle use in hyperthermia treatment, and precision medicine approaches targeting choline kinase and related pathways.

Best Publications

  • Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

    R Perona;S Montaner;L Saniger;I Sánchez-Pérez

  • Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

    Ana Ramı́rez de Molina;Agustı́n Rodrı́guez-González;Ruth Gutiérrez;Luis Martı́nez-Piñeiro

  • Rho signals to cell growth and apoptosis.

    Salvador Aznar;Juan Carlos Lacal

  • Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha- ras oncogene

    Juan Carlos Lacal;Jorge Moscat;Stuart A. Aaronson

  • Rho GTPase expression in tumourigenesis: evidence for a significant link.

    Teresa Gómez del Pulgar;Salvador A. Benitah;Pilar F. Valerón;Carolina Espina

  • Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.

    Ana Ramírez de Molina;Ruth Gutiérrez;Maria Angeles Ramos;José María Silva

  • Multiple signalling pathways lead to the activation of the nuclear factor κB by the Rho family of GTPases

    Silvia Montaner;Rosario Perona;Luisa Saniger;Juan Carlos Lacal

  • Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.

    Antonio Cuadrado;Amancio Carnero;F. Dolfi;Benilde Jiménez

  • Choline kinase inhibitors as a novel approach for antiproliferative drug design

    R Hernández-Alcoceba;L Saniger;J Campos;M C Núñez

  • Rho proteins induce metastatic properties in vivo.

    del Peso L;del Peso L;Hernández-Alcoceba R;Embade N;Carnero A

  • Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.

    María Virtudes Céspedes;Carolina Espina;Miguel Angel García-Cabezas;Miguel Angel García-Cabezas;Manuel Trias

  • A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

    E G Lapetina;J C Lacal;B R Reep;L Molina y Vedia

  • Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation.

    Salvador A. Benitah;Pilar F. Valerón;Linda van Aelst;Christopher J. Marshall

  • Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study

    Ana Ramírez de Molina;Jacinto Sarmentero-Estrada;Cristóbal Belda-Iniesta;Cristóbal Belda-Iniesta;Miquel Tarón

  • Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.

    Ana Ramírez de Molina;Mónica Báñez-Coronel;Ruth Gutiérrez;Agustín Rodríguez-González

  • In Vivo Antitumor Activity of Choline Kinase Inhibitors: A Novel Target for Anticancer Drug Discovery

    Rubén Hernández-Alcoceba;Félix Fernández;Juan Carlos Lacal

  • Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

    Nada M.S. Al-Saffar;Helen Troy;Ana Ramírez de Molina;Laura E. Jackson

  • Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.

    Elsa Sanchez-Lopez;Zhenyu Zhong;Zhenyu Zhong;Alexandra Stubelius;Shannon R. Sweeney

  • Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H-ras p21

    JC Lacal;P de la Pena;J Moscat;P Garcia-Barreno

  • Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

    J C Lacal;T P Fleming;B S Warren;P M Blumberg

Frequent Co-Authors

Stuart A. Aaronson
Stuart A. Aaronson Icahn School of Medicine at Mount Sinai
Amancio Carnero
Amancio Carnero Spanish National Research Council
Salvador Aznar Benitah
Salvador Aznar Benitah Institució Catalana de Recerca i Estudis Avançats
Luis Carrasco
Luis Carrasco Centro de Biología Molecular Severo Ochoa
Paul Workman
Paul Workman Institute of Cancer Research
Antonio Cuadrado
Antonio Cuadrado Autonomous University of Madrid
Martin O. Leach
Martin O. Leach Royal Marsden NHS Foundation Trust
Jorge Moscat
Jorge Moscat Cornell University
Axel Ullrich
Axel Ullrich Max Planck Institute of Biochemistry
John R. Griffiths
John R. Griffiths University of Manchester

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