World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
16013
World Ranking
16461
National Ranking
6813

Overview

Jose M. Silva is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant number of publications in the field. Within this broader domain, Silva has contributed extensively to molecular biology, biomedical engineering, cancer research, oncology, and cell biology.

Silva's scholarly output includes a focus on several key topics, reflecting a broad and multidisciplinary approach. These topics include pluripotent stem cells research, CRISPR and genetic engineering, 3D printing in biomedical research, single-cell and spatial transcriptomics, histone deacetylase inhibitors research, protein degradation and inhibitors, and ubiquitin and proteasome pathways.

The scientist has published in a variety of journals and venues. Their most frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory) with six publications, Cellular Reprogramming and Cancer Research with three publications each, as well as Nature Communications and Developmental Cell, each with two publications.

Jose M. Silva has recently contributed to a number of significant research papers. Among them are:

  • "OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms," published in 2021 in Proceedings of the National Academy of Sciences
  • "StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells," published in 2021 in Nature Communications
  • "Misfire detection of an internal combustion engine based on vibration and acoustic analysis," published in 2021 in Journal of the Brazilian Society of Mechanical Sciences and Engineering
  • "Auxin-degron system identifies immediate mechanisms of OCT4," published in 2021 in Stem Cell Reports
  • "Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously," published in 2024 in Nature Communications

Throughout their career, Silva has collaborated frequently with several coauthors. These include Lawrence E. Bates, Jiyang Yu, Chuanxin Chen, Tizita Zeleke, and Qingfei Pan, reflecting ongoing research partnerships across multiple projects.

Best Publications

  • Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

    Manel Esteller;Jose Maria Silva;Gemma Dominguez;Felix Bonilla

  • A resource for large-scale RNA-interference-based screens in mammals

    Patrick J. Paddison;Jose M. Silva;Douglas S. Conklin;Douglas S. Conklin;Mike Schlabach;Mike Schlabach

  • Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

    William A. Freed-Pastor;Hideaki Mizuno;Xi Zhao;Anita Langerød

  • Second-generation shRNA libraries covering the mouse and human genomes.

    Jose M Silva;Mamie Z Li;Ken Chang;Wei Ge

  • An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma.

    Pavel Sumazin;Xuerui Yang;Hua-Sheng Chiu;Wei-Jen Chung

  • A micrococcal nuclease homologue in RNAi effector complexes

    Amy A. Caudy;René F. Ketting;Scott M. Hammond;Scott M. Hammond;Ahmet M. Denli

  • EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

    Elena Ezhkova;Wen-Hui Lien;Nicole Stokes;H. Amalia Pasolli

  • Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

    Josep Domingo-Domenech;Samuel J. Vidal;Veronica Rodriguez-Bravo;Mireia Castillo-Martin

  • Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening

    Jose M. Silva;Krista Marran;Joel S. Parker;Javier Silva

  • Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations.

    Jose M. Silva;Gemma Dominguez;Jose M. Garcia;Rocio Gonzalez

  • Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival

    J. Silva;V. García;Á. Zaballos;M. Provencio

  • Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy.

    Ana Ramírez de Molina;Ruth Gutiérrez;Maria Angeles Ramos;José María Silva

  • Analysis of exosome release and its prognostic value in human colorectal cancer

    J. Silva;V. Garcia;M. Rodriguez;M. Compte

  • Deregulated expression of miR-106a predicts survival in human colon cancer patients

    Díaz R;Silva J;García Jm;Lorenzo Y

  • RNA interference microarrays: High-throughput loss-of-function genetics in mammalian cells

    Jose M. Silva;Hana Mizuno;Amy Brady;Robert Lucito

  • Detection of epithelial messenger RNA in the plasma of breast cancer patients is associated with poor prognosis tumor characteristics.

    Jose M. Silva;Gemma Dominguez;Javier Silva;Jose M. Garcia

  • Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival.

    Jose M Silva;Javier Silva;Antonio Sanchez;Jose M Garcia

  • Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients.

    J M Silva;G Dominguez;M J Villanueva;R Gonzalez

  • Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells

    J M Silva;R Rodriguez;J M Garcia;C Muñoz

  • Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer.

    José M Silva;Gemma Domínguez;José M González-Sancho;José M García

Frequent Co-Authors

Andrea Califano
Andrea Califano Columbia University
Carlos Cordon-Cardo
Carlos Cordon-Cardo Icahn School of Medicine at Mount Sinai
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Dana Pe'er
Dana Pe'er Memorial Sloan Kettering Cancer Center
Antonio Iavarone
Antonio Iavarone Columbia University Medical Center
Dawn L. Hershman
Dawn L. Hershman Columbia University
Ravi Sachidanandam
Ravi Sachidanandam Icahn School of Medicine at Mount Sinai
Stephen J. Elledge
Stephen J. Elledge Harvard University
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center

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