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John C. Hedreen

John C. Hedreen

D-Index & Metrics

Neuroscience

D-Index
54
Citations
22692
World Ranking
4828
National Ranking
2170

Overview

John C. Hedreen is affiliated with McLean Hospital in the United States. Their research primarily focuses on medicine and neuroscience, with significant contributions in neurology, physiology, computational theory and mathematics, psychiatry and mental health, and cellular and molecular neuroscience.

The main topics of their work cover a broad spectrum within neurological and neurodegenerative research:

  • Alzheimer's disease research and treatments
  • Computational drug discovery methods
  • Dementia and cognitive impairment research
  • Genetic neurodegenerative diseases
  • Neurological disorders and treatments
  • Mitochondrial function and pathology
  • Parkinson's disease mechanisms and treatments

Recent publications by John C. Hedreen demonstrate an engagement with neuropathology and neurodegenerative disease mechanisms. Notable papers include:

  • "Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease," published in 2020 in Cell
  • "Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates," published in 2020 in Acta Neuropathologica
  • "Postmortem neuropathology in early Huntington disease," published in 2024 in Journal of Neuropathology & Experimental Neurology

Their work has been disseminated through venues such as Cell, Journal of Neuropathology & Experimental Neurology, and Acta Neuropathologica. Each of these reflects a focus on experimental and clinical neuropathology as well as cellular mechanisms relevant to neurodegeneration.

Collaboration plays a role in their academic output. Frequent co-authors include Sabina Berretta, Hendrik Wesseling, Waltraud Mair, Mukesh Kumar, and Christoph N. Schlaffner, indicating a network of researchers engaged in complementary areas of neuroscience and medicine.

Best Publications

  • PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

    Bin Zheng;Zhixiang Liao;Joseph J. Locascio;Kristen A. Lesniak

  • Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

    Carlos Portera-Cailliau;John C. Hedreen;Donald L. Price;Vassilis E. Koliatsos

  • Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats.

    Rubinsztein Dc;Leggo J;Coles R;Almqvist E

  • Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system.

    Michael McKinney;Joseph T. Coyle;John C. Hedreen

  • Basal forebrain neurons in the dementia of Parkinson disease

    Peter J. Whitehouse;John C. Hedreen;Charles L. White;Donald L. Price

  • Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

    Hendrik Wesseling;Waltraud Mair;Mukesh Kumar;Christoph N. Schlaffner

  • A modified histochemical technique to visualize acetylcholinesterase-containing axons.

    John C. Hedreen;Sarah J. Bacon;Donald L. Price

  • Widespread expression of Huntington's disease gene (IT15) protein product

    Alan H. Sharp;Scott J. Loev;Gabriele Schilling;Shi Hua Li

  • THE NEUROPATHOLOGY OF AMINERGIC NUCLEI IN ALZHEIMER??S DISEASE

    R. M. Zweig;C. A. Ross;J. C. Hedreen;C. Steele

  • The pedunculopontine nucleus in Parkinson's disease

    R. M. Zweig;W. R. Jankel;J. C. Hedreen;R. Mayeux

  • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology Confirmation of the Clinical Diagnosis of Alzheimer's Disease

    M. Gearing;S. S. Mirra;J. C. Hedreen;S. M. Sumi

  • Early loss of neostriatal striosome neurons in Huntington's disease.

    John C. Hedreen;Susan E. Folstein

  • Huntington's disease gene (IT15) is widely expressed in human and rat tissues.

    S.-H. Li;G. Schilling;W.S. Young;X.-. Li

  • Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease.

    John C. Hedreen;Carol E. Peyser;Susan E. Folstein;Christopher A. Ross

  • Organization of striatopallidal, striatonigral, and nigrostriatal projections in the macaque.

    John C. Hedreen;Marlon R. Delong

  • Parkinson's disease: loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions.

    George R. Uhl;John C. Hedreen;Donald L. Price

  • Topography of the magnocellular basal forebrain system in human brain.

    John C. Hedreen;Robert G. Struble;Peter J. Whitehouse;Donald L. Price

  • Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study.

    J.C. Hedreen;J.P. Chalmers

  • The locus ceruleus and dementia in Parkinson's disease

    R. M. Zweig;J. E. Cardillo;M. Cohen;S. Giere

  • TorsinA protein and neuropathology in early onset generalized dystonia with GAG deletion.

    Kevin Rostasy;Sarah J. Augood;Jeffrey W. Hewett;Joanne Chung On Leung

  • Neuropathology of aminergic nuclei in Alzheimer's disease.

    R. M. Zweig;C. A. Ross;J. C. Hedreen;C. Steele

  • Tracing Neural Connections with Horseradish Peroxidase: edited by M.-Marsel Mesulam, John Wiley & Sons, 1982.£11.00 (xvi + 251 pages) ISBN 0 471 10029 3

    John C. Hedreen

Frequent Co-Authors

Peter J. Whitehouse
Peter J. Whitehouse Case Western Reserve University
Joseph T. Coyle
Joseph T. Coyle Harvard University
Joseph J. Locascio
Joseph J. Locascio Harvard University
Cheryl A. Kitt
Cheryl A. Kitt Johns Hopkins University School of Medicine
Glenda M. Halliday
Glenda M. Halliday University of Sydney
Linda C. Cork
Linda C. Cork Stanford University
Robert G. Struble
Robert G. Struble Southern Illinois University School of Medicine
John S. Mattick
John S. Mattick University of New South Wales
Shihua Li
Shihua Li Southeast University
Xandra O. Breakefield
Xandra O. Breakefield Harvard University

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