World's Best Scientists 2026 revealed!

Overview

Jesper Lau is affiliated with Novo Nordisk in Denmark and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work focuses extensively on Endocrinology, Diabetes and Metabolism, with additional contributions to Surgery, Molecular Biology, and Spectroscopy.

Their research topics encompass several areas related to metabolic diseases and biochemical analysis. Key topics include:

  • Diabetes Treatment and Management
  • Pancreatic function and diabetes
  • Metabolism, Diabetes, and Cancer
  • Diet, Metabolism, and Disease
  • Analytical Chemistry and Chromatography
  • Protein purification and stability
  • Mass Spectrometry Techniques and Applications

Jesper Lau has published papers across multiple scientific journals. Their frequent publication venues are:

  • PLoS ONE
  • iScience
  • Molecular Metabolism
  • LCGC Europe
  • SSRN Electronic Journal

Selected recent publications include:

  • Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls, 2022, PLoS ONE
  • Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells, 2022, iScience
  • Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice, 2022, Molecular Metabolism
  • Method Development for Reversed-Phase Separations of Peptides: A Rational Screening Strategy for Column and Mobile Phase Combinations with Complementary Selectivity, 2022, LCGC Europe
  • Hepatic Glucagon Receptor Signaling Controls Amino Acid Metabolism and Regulates Alpha Cell Mass, 2022, SSRN Electronic Journal

Jesper Lau has collaborated frequently with several researchers, including:

  • Thomas Kruse
  • Emilie Elmelund
  • Katrine D. Galsgaard
  • Christian D. Johansen
  • Anna Billeschou

Best Publications

  • Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

    Jesper Lau;Paw Bloch;Lauge Schäffer;Ingrid Pettersson

  • Structure of the human glucagon class B G-protein-coupled receptor

    Fai Yiu Siu;Min He;Chris De Graaf;Gye Won Han

  • Glucagon-like peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes

    Chris de Graaf;Dan Donnelly;Denise Wootten;Jesper Lau

  • Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

    Steffen Runge;Henning Thøgersen;Kjeld Madsen;Jesper Lau

  • Compounds with growth hormone releasing properties

    Thomas Kruse Hansen;Bernd Peschke;Jesper Lau;Behrend Friedrich Lundt

  • Novel Glp-1 Derivatives

    Jesper Lau;Thomas Kruse Hansen;Kjeld Madsen;Paw Bloch

  • Small-molecule agonists for the glucagon-like peptide 1 receptor

    Lotte Bjerre Knudsen;Dan Kiel;Min Teng;Carsten Behrens

  • Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

    Gaojie Song;Dehua Yang;Yuxia Wang;Chris de Graaf

  • Structure of the full-length glucagon class B G-protein-coupled receptor

    Haonan Zhang;Anna Qiao;Dehua Yang;Linlin Yang

  • Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

    Henrik Sune Andersen;Ole H. Olsen;Lars F. Iversen;Anette L. P. Sørensen

  • Aryl carbonyl derivatives as therapeutic agents

    Dharma Rao Polisetti;János Tibor Kodra;Jesper Lau;Paw Bloch

  • Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

    Peter Madsen;Anthony Ling;Michael Plewe;Christian K Sams

  • Structure of the glucagon receptor in complex with a glucagon analogue

    Haonan Zhang;Anna Qiao;Linlin Yang;Ned Van Eps

  • N-Substituted Adenosines as Novel Neuroprotective A1 Agonists with Diminished Hypotensive Effects

    Lars J. S. Knutsen;Jesper Lau;Hans Petersen;Christian Thomsen

  • Novel glucagon analogues

    Jesper F. Lau;Thomas Kruse;Lars Linderoth;Henning Thøgersen

  • Identification of Alkylidene Hydrazides as Glucagon Receptor Antagonists

    Anthony Ling;Yufeng Hong;Javier Gonzalez;Vlad Gregor

  • Acylated exendin-4 compounds

    Jesper Lau;Thomas Kruse Hansen;Leif Christensen;Kjeld Madsen

  • Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.

    L F Iversen;H S Andersen;K B Møller;O H Olsen

  • Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-thiadiazoles and [1,3,4]-oxadiazoles

    Rune Severinsen;John Paul Kilburn;Jesper F. Lau

  • Protracted exendin-4 compounds

    Jesper Lau;Thomas Kruse Hansen

Frequent Co-Authors

Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences
Günther H.J. Peters
Günther H.J. Peters Technical University of Denmark
Chris de Graaf
Chris de Graaf Vrije Universiteit Amsterdam
Wayne I. Lencer
Wayne I. Lencer Harvard University
Raymond C. Stevens
Raymond C. Stevens University of Southern California
Hans Bräuner-Osborne
Hans Bräuner-Osborne University of Copenhagen
Gye Won Han
Gye Won Han University of Southern California
Joel F. Habener
Joel F. Habener Harvard University
Claes B. Wollheim
Claes B. Wollheim University of Geneva
Melanie J. Davies
Melanie J. Davies University of Leicester

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