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Biology and Biochemistry

D-Index
63
Citations
19831
World Ranking
10026
National Ranking
4388

Overview

Henry N. Higgs is affiliated with Dartmouth College in the United States and specializes in the fields of Biochemistry, Genetics and Molecular Biology with a focus on Molecular Biology and Cell Biology. Their research portfolio includes significant work across several subfields such as Cellular and Molecular Neuroscience, Clinical Biochemistry, and Nephrology.

The primary research topics Henry N. Higgs has contributed to are:

  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Genetic Neurodegenerative Diseases
  • Metabolism and Genetic Disorders
  • Cellular Mechanics and Interactions
  • Ubiquitin and proteasome pathways
  • Autophagy in Disease and Therapy

Their recent publications demonstrate an emphasis on actin dynamics and mitochondrial mechanisms. Notable papers include:

  • The multiple links between actin and mitochondria (2023), Nature Reviews Molecular Cell Biology
  • Multiple roles for actin in secretory and endocytic pathways (2021), Current Biology
  • Lysine acetylation of cytoskeletal proteins: Emergence of an actin code (2020), The Journal of Cell Biology
  • Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division (2021), Molecular Biology of the Cell
  • INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury (2022), Nature Communications

Henry N. Higgs frequently collaborates with several coauthors in their field, including:

  • Rajarshi Chakrabarti
  • Tak Shun Fung
  • Ao Liu
  • Miriam Lee
  • Frieda Kage

Their work has appeared across multiple scientific venues, highlighting contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Current Biology
  • Molecular Biology of the Cell
  • Nature Reviews Molecular Cell Biology
  • The Journal of Cell Biology

Best Publications

  • Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex.

    Machesky Lm;Mullins Rd;Higgs Hn;Kaiser Da

  • The many faces of actin: matching assembly factors with cellular structures

    Ekta Seth Chhabra;Henry N. Higgs

  • Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.

    Henry N. Higgs;Thomas D. Pollard

  • An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2.

    Farida Korobova;Vinay Ramabhadran;Henry N. Higgs

  • Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins.

    Laurent Blanchoin;Kurt J. Amann;Henry N. Higgs;Jean-Baptiste Marchand

  • Crystal Structure of Arp2/3 Complex

    Robert C. Robinson;Kirsi Turbedsky;Donald A. Kaiser;Jean-Baptiste Marchand

  • Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

    Henry N. Higgs;Thomas D. Pollard

  • The Human Androgen Receptor: Complementary Deoxyribonucleic Acid Cloning, Sequence Analysis and Gene Expression in Prostate

    Dennis B. Lubahn;David R. Joseph;Madhabananda Sar;Jiann An Tan

  • Control of the assembly of ATP- and ADP-actin by formins and profilin.

    David R. Kovar;Elizabeth S. Harris;Rachel Mahaffy;Henry N. Higgs

  • Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.

    Dennis B. Lubahn;Terry R. Brown;Jorge A. Simental;Henry N. Higgs

  • The Mouse Formin mDia1 Is a Potent Actin Nucleation Factor Regulated by Autoinhibition

    Fang Li;Henry N. Higgs

  • Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis

    Elizabeth J Brown;Johannes S Schlöndorff;Johannes S Schlöndorff;Daniel J Becker;Daniel J Becker;Hiroyasu Tsukaguchi;Hiroyasu Tsukaguchi;Hiroyasu Tsukaguchi

  • Formin proteins: a domain-based approach.

    Henry N. Higgs

  • Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.

    Melanie Barzik;Tatyana I. Kotova;Henry N. Higgs;Larnele Hazelwood

  • Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

    Jean-Baptiste Marchand;Donald A. Kaiser;Thomas D. Pollard;Henry N. Higgs

  • Regulation of Actin Polymerization by Arp2/3 Complex and WASp/Scar Proteins

    Henry N. Higgs;Thomas D. Pollard

  • Phylogenetic analysis of the formin homology 2 domain.

    Henry N. Higgs;Kevin J. Peterson

  • Influence of the C Terminus of Wiskott-Aldrich Syndrome Protein (WASp) and the Arp2/3 Complex on Actin Polymerization†

    Henry N. Higgs;Laurent Blanchoin;Thomas D. Pollard

  • Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

    Wei-ke Ji;Anna L Hatch;Ronald A Merrill;Stefan Strack

  • Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3

    Jean-Baptiste Marchand;Donald A. Kaiser;Thomas D. Pollard;Henry N. Higgs

Frequent Co-Authors

Thomas D. Pollard
Thomas D. Pollard Yale University
Martin R. Pollak
Martin R. Pollak Beth Israel Deaconess Medical Center
Laurent Blanchoin
Laurent Blanchoin Grenoble Alpes University
Stefan Strack
Stefan Strack University of Iowa
Frank S. French
Frank S. French University of North Carolina at Chapel Hill
Seth L. Alper
Seth L. Alper Beth Israel Deaconess Medical Center
Elizabeth M. Wilson
Elizabeth M. Wilson University of North Carolina at Chapel Hill
Emil Reisler
Emil Reisler University of California, Los Angeles
Francesca Demichelis
Francesca Demichelis University of Trento
Dennis B. Lubahn
Dennis B. Lubahn University of Missouri

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