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Biology and Biochemistry

D-Index
82
Citations
24746
World Ranking
3688
National Ranking
1836

Overview

Frank S. French is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with substantial work also situated within several related subfields including Pulmonary and Respiratory Medicine, Molecular Biology, Endocrinology, Diabetes and Metabolism, Genetics, and Oncology.

Their scholarly output includes a series of research papers focused on hormonal mechanisms, prostate cancer, and genetic aspects relevant to sex determination and endocrine functions. Notable recent publications include:

  • Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism, 2020, UNC Libraries
  • Androgen Receptor Expression and Cellular Proliferation During Transition from Androgen-Dependent to Recurrent Growth after Castration in the CWR22 Prostate Cancer Xenograft, 2020, UNC Libraries
  • Probing the Functional Link between Androgen Receptor Coactivator and Ligand-binding Sites in Prostate Cancer and Androgen Insensitivity, 2021, UNC Libraries
  • Molecular cloning of rat prostate transglutaminase complementary DNA: the major androgen-regulated protein Dp1 of rat dorsal prostate and coagulating gland, 2021, UNC Libraries
  • Epidermal Growth Factor Increases Coactivation of the Androgen Receptor in Recurrent Prostate Cancer, 2021, UNC Libraries

Frequent coauthors in their research collaborations include Elizabeth M. Wilson, Christopher W. Gregory, Peter Petrusz, James L. Mohler, and Emily Wilson, reflecting sustained interdisciplinary partnerships.

Their work has been predominantly published in the venue UNC Libraries, where at least 15 publications have been recorded, illustrating a close association with this institution for dissemination of research findings.

Frank S. French's main research topics are oriented toward:

  • Prostate Cancer Treatment and Research
  • Hormonal and reproductive studies
  • Estrogen and related hormone effects
  • Sexual Differentiation and Disorders
  • 14-3-3 protein interactions
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Prostate Cancer Diagnosis and Treatment

This profile reflects their body of work as it pertains to molecular and clinical investigations with a focus on androgen receptors, cancer biology, hormonal regulation, and genetic characterization within their fields of study.

Best Publications

  • Androgen receptor defects : Historical, clinical, and molecular perspectives

    Charmian A. Quigley;Alessandra De Bellis;Keith B. Marschke;Mostafa K. El-Awady

  • Cloning of human androgen receptor complementary DNA and localization to the X chromosome.

    Dennis B. Lubahn;David R. Joseph;Patrick M. Sullivan;Huntington F. Willard

  • TRANSCRIPTIONAL ACTIVATION AND NUCLEAR TARGETING SIGNALS OF THE HUMAN ANDROGEN RECEPTOR

    Jorge A. Simental;Madhabananda Sar;Malcolm V. Lane;Frank S. French

  • The Androgen Axis in Recurrent Prostate Cancer

    James L. Mohler;Christopher W. Gregory;O. Harris Ford;Desok Kim

  • A Mechanism for Androgen Receptor-mediated Prostate Cancer Recurrence after Androgen Deprivation Therapy

    C. W. Gregory;Bin He;R. T. Johnson;O. H. Ford

  • Androgen Receptor Stabilization in Recurrent Prostate Cancer Is Associated with Hypersensitivity to Low Androgen

    Christopher W. Gregory;Raymond T. Johnson;James L. Mohler;Frank S. French

  • The Human Androgen Receptor: Complementary Deoxyribonucleic Acid Cloning, Sequence Analysis and Gene Expression in Prostate

    Dennis B. Lubahn;David R. Joseph;Madhabananda Sar;Jiann An Tan

  • Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.

    Dennis B. Lubahn;Terry R. Brown;Jorge A. Simental;Henry N. Higgs

  • Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability.

    Zhong Xun Zhou;Malcolm V. Lane;Jon A. Kemppainen;Frank S. French

  • Immunohistochemical Localization of the Androgen Receptor in Rat and Human Tissues

    Madhabananda Sar;Dennis B. Lubahn;Frank S. French;Elizabeth M. Wilson

  • Dehydroepiandrosterone Activates Mutant Androgen Receptors Expressed in the Androgen-Dependent Human Prostate Cancer Xenograft CWR22 and LNCaP Cells

    Jiann An Tan;Yousuf Sharief;Katherine G. Hamil;Christopher W. Gregory

  • Androgen Receptor Expression in Androgen-independent Prostate Cancer Is Associated with Increased Expression of Androgen-regulated Genes

    Christopher W. Gregory;Katherine G. Hamil;Desok Kim;Susan H. Hall

  • The Rat Androgen Receptor: Primary Structure, Autoregulation of its Messenger Ribonucleic Acid, and Immunocytochemical Localization of the Receptor Protein

    Jiann An Tan;David R. Joseph;Valerie E. Quarmby;Dennis B. Lubahn

  • Androgen transport and receptor mechanisms in testis and epididymis

    V. Hansson;O. Trygstad;Frank S French;W. S. McLean

  • Steroid Binding in Polyacrylamide Gels: QUANTITATION AT STEADY STATE CONDITIONS

    E. Martin Ritzén;Frank S. French;Samuel C. Weddington;Shihadeh N. Nayfeh

  • Autologous down-regulation of androgen receptor messenger ribonucleic acid.

    Valerie E. Quarmby;Wendell G. Yarbrough;Dennis B. Lubahn;Frank S. French

  • Purification and Localization of Acidic Epididymal Glycoprotein (AEG): A Sperm Coating Protein Secreted by the Rat Epididymis

    Oscar A. Lea;Peter Petrusz;Frank S. French

  • Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.

    Christopher W. Gregory;Xiaoyin Fei;Liliana A. Ponguta;Bin He

  • A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.

    W. G. Yarbrough;V. E. Quarmby;J. A. Simental;D. R. Joseph

  • A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse.

    Nancy J. Charest;Zhong xun Zhou;Dennis B. Lubahn;Kathie L. Olsen

Frequent Co-Authors

Elizabeth M. Wilson
Elizabeth M. Wilson University of North Carolina at Chapel Hill
Dennis B. Lubahn
Dennis B. Lubahn University of Missouri
Vidar Hansson
Vidar Hansson University of Oslo
James L. Mohler
James L. Mohler Roswell Park Cancer Institute
Madhabananda Sar
Madhabananda Sar Research Triangle Park Foundation
Judson J. Van Wyk
Judson J. Van Wyk University of North Carolina at Chapel Hill
Michael G. O'Rand
Michael G. O'Rand University of North Carolina at Chapel Hill
Louis E. Underwood
Louis E. Underwood University of North Carolina at Chapel Hill
Steven M. Ruben
Steven M. Ruben Celera Corporation
David H. Viskochil
David H. Viskochil University of Utah

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