His primary areas of investigation include Androgen receptor, Molecular biology, Internal medicine, Endocrinology and Receptor. His Androgen receptor research includes themes of Androgen, LNCaP, Binding site and Cell biology. His research integrates issues of Amino acid, DNA-binding domain, Transcription factor, Complementary DNA and Promoter in his study of Molecular biology.
His research investigates the link between Internal medicine and topics such as Mutation that cross with problems in Testicular feminization and Allele frequency. His Endocrinology study which covers Regulation of gene expression that intersects with Androgen binding. His research in Receptor intersects with topics in Cancer research, Insulin and Mechanism of action.
Albert O. Brinkmann mainly focuses on Androgen receptor, Internal medicine, Endocrinology, Receptor and Androgen. His Androgen receptor research incorporates elements of Molecular biology, Biochemistry and LNCaP. His study in Internal medicine is interdisciplinary in nature, drawing from both Regulation of gene expression, Cancer research, Nuclear receptor and Gene expression.
He interconnects Cell culture and In vitro in the investigation of issues within Endocrinology. As a member of one scientific family, he mostly works in the field of Receptor, focusing on Cell biology and, on occasion, Transcription factor. His work deals with themes such as Immunohistochemistry and Seminal vesicle, which intersect with Androgen.
His primary areas of study are Internal medicine, Endocrinology, Androgen receptor, Receptor and Transactivation. In general Internal medicine study, his work on Glucocorticoid receptor, Androgen and Glucocorticoid often relates to the realm of Rotterdam Study, thereby connecting several areas of interest. He has researched Endocrinology in several fields, including Regulation of gene expression, Prostate cancer, Transfection and Cancer research.
His research integrates issues of Prostate and LNCaP in his study of Cancer research. His Androgen receptor study combines topics from a wide range of disciplines, such as Mutation, Nuclear receptor, Biochemistry and Molecular biology. His Receptor research is multidisciplinary, incorporating perspectives in Proteomics and Seminal vesicle.
Albert O. Brinkmann spends much of his time researching Internal medicine, Endocrinology, Glucocorticoid receptor, Glucocorticoid and Transactivation. His Internal medicine study focuses mostly on Androgen insensitivity syndrome, Androgen receptor and Prostate cancer. His Androgen receptor research integrates issues from Nuclear receptor coactivator 2, Peptide sequence, Estrogen receptor, Protein structure and Binding site.
His research on Glucocorticoid receptor concerns the broader Receptor. The study incorporates disciplines such as Molecular biology, Gene and Polymorphism in addition to Glucocorticoid. His biological study spans a wide range of topics, including Mutation and Missense mutation.
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A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens.
J. Veldscholte;C. Ris-Stalpers;G.G.J.M. Kuiper;G. Jenster.
Biochemical and Biophysical Research Communications (1990)
Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.
Stephan Zimmermann;Gerd Steding;Judith M. A. Emmen;Albert O. Brinkmann.
Molecular Endocrinology (1999)
A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo
N. A. T. M. Huizenga;J. W. Koper;P. De Lange;H. A. P. Pols.
The Journal of Clinical Endocrinology and Metabolism (1998)
The promoter of the prostate-specific antigen gene contains a functional androgen responsive element.
P. H. J. Riegman;R. J. Vlietstra;J. A. G. M. van der Korput;A. O. Brinkmann.
Molecular Endocrinology (1991)
Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization.
Guido Jenster;Hetty A. G. M. van der Korput;Cor van Vroonhoven;Theo H. van der Kwast.
Molecular Endocrinology (1991)
Two Androgen Response Regions Cooperate in Steroid Hormone Regulated Activity of the Prostate-specific Antigen Promoter (∗)
Kitty B.J.M. Cleutjens;Conny C.E.M. van Eekelen;Hetty A.G.M. van der Korput;Albert O. Brinkmann.
Journal of Biological Chemistry (1996)
The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
J. Veldscholte;C.A. Berrevoets;C. Ris-Stalpers;G.G.J.M. Kuiper.
The Journal of Steroid Biochemistry and Molecular Biology (1992)
Cloning, structure and expression of a cDNA encoding the human androgen receptor.
J. Trapman;P. Klaassen;G.G.J.M. Kuiper;J.A.G.M. van der Korput.
Biochemical and Biophysical Research Communications (1988)
Identification of two transcription activation units in the N-terminal domain of the human androgen receptor.
Guido Jenster;Hetty A.G.M. van der Korput;Jan Trapman;Albert O. Brinkmann.
Journal of Biological Chemistry (1995)
The human androgen receptor: domain structure, genomic organization and regulation of expression.
A.O. Brinkmann;P.W. Faber;H.C.J. van Rooij;G.G.J.M. Kuiper.
Journal of Steroid Biochemistry (1989)
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