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Guy Eelen

Guy Eelen

D-Index & Metrics

Molecular Biology

D-Index
53
Citations
14573
World Ranking
2364
National Ranking
30

Overview

Guy Eelen is a researcher affiliated with KU Leuven in Belgium, specializing primarily in Biochemistry, Genetics, and Molecular Biology, with additional contributions in Medicine. Their work encompasses various subfields including Molecular Biology, Cancer Research, Immunology, Pulmonary and Respiratory Medicine, and Cell Biology.

The scientist's research focuses on topics such as single-cell and spatial transcriptomics, angiogenesis and VEGF in cancer, immune cells in cancer, cancer-related hypoxia and metabolism, epigenetics and DNA methylation, congenital heart defects research, and RNA modifications in cancer.

Eelen has published extensively in several high-impact scientific venues. Notable journals where their research appears include:

  • Nature
  • STAR Protocols
  • Nature Communications
  • Cell Reports
  • Cancer Cell

Recent papers authored or co-authored by Eelen and colleagues include:

  • Basic and Therapeutic Aspects of Angiogenesis Updated, 2020, Circulation Research
  • Single-Cell Transcriptome Atlas of Murine Endothelial Cells, 2020, Cell
  • An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates, 2020, Cancer Cell
  • Immunomodulation by endothelial cells - partnering up with the immune system?, 2022, Nature Reviews. Immunology
  • Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis, 2020, Cell Metabolism

Collaboration forms an important component of Eelen's work. Frequent co-authors include:

  • Peter Carmeliet
  • Mieke Dewerchin
  • Lucas Treps
  • Luc Schoonjans
  • Laura de Rooij

Best Publications

  • Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

    Katrien De Bock;Maria Georgiadou;Sandra Schoors;Anna Kuchnio

  • Single-Cell Transcriptome Atlas of Murine Endothelial Cells

    Joanna Kalucka;Laura P.M.H. de Rooij;Jermaine Goveia;Katerina Rohlenova

  • Endothelial cell metabolism in normal and diseased vasculature

    Guy Eelen;Pauline de Zeeuw;Michael Simons;Peter Carmeliet

  • Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

    Anna Rita Cantelmo;Lena Christin Conradi;Aleksandra Brajic;Jermaine Goveia

  • Fatty acid carbon is essential for dNTP synthesis in endothelial cells

    Sandra Schoors;Ulrike Bruning;Rindert Missiaen;Karla C S Queiroz

  • FOXO1 couples metabolic activity and growth state in the vascular endothelium.

    Kerstin Wilhelm;Katharina Happel;Guy Eelen;Sandra Schoors

  • Vitamin D and cancer.

    Roger Bouillon;Guy Eelen;Lieve Verlinden;Chantal Mathieu

  • Endothelial Cell Metabolism

    Guy Eelen;Guy Eelen;Pauline de Zeeuw;Pauline de Zeeuw;Lucas Treps;Lucas Treps;Ulrike Harjes;Ulrike Harjes

  • Basic and Therapeutic Aspects of Angiogenesis Updated

    Guy Eelen;Lucas Treps;Xuri Li;Peter Carmeliet;Peter Carmeliet

  • An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

    Jermaine Goveia;Katerina Rohlenova;Federico Taverna;Lucas Treps

  • The role of fatty acid β-oxidation in lymphangiogenesis

    Brian W. Wong;Xingwu Wang;Annalisa Zecchin;Bernard Thienpont

  • Role of glutamine and interlinked asparagine metabolism in vessel formation

    Hongling Huang;Saar Vandekeere;Joanna Kalucka;Laura Bierhansl

  • Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.

    Gabriela Bomfim Ferreira;An-Sofie Vanherwegen;Guy Eelen;Ana Carolina Fierro Gutiérrez

  • HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

    Steve Stegen;Kjell Laperre;Guy Eelen;Gianmarco Rinaldi

  • Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

    Joanna Kalucka;Joanna Kalucka;Laura Bierhansl;Nadine Vasconcelos Conchinha;Rindert Missiaen

  • Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.

    Katerina Rohlenova;Jermaine Goveia;Melissa García-Caballero;Abhishek Subramanian

  • Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

    Guy Eelen;Guy Eelen;Charlotte Dubois;Anna Rita Cantelmo;Anna Rita Cantelmo;Jermaine Goveia

  • Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

    Christian Lange;Miguel Turrero Garcia;Ilaria Decimo;Francesco Bifari

  • The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas.

    Lieve Verlinden;Isabelle Vanden Bempt;Guy Eelen;Maria Drijkoningen

  • HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

    Steve Stegen;Nick van Gastel;Guy Eelen;Bart Ghesquière

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