World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
57
Citations
33255
World Ranking
3352
National Ranking
13

Research.com Recognitions

  • 1970 - Fellow of Alfred P. Sloan Foundation

Overview

Gerard Manning is affiliated with University College Cork in Ireland and has produced significant research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields, with a particular focus on Molecular Biology, Cell Biology, Pulmonary and Respiratory Medicine, Oncology, and Cancer Research.

The main topics of Gerard Manning's research include:

  • Nuclear Structure and Function
  • RNA Research and Splicing
  • Cancer Genomics and Diagnostics
  • Lung Cancer Treatments and Mutations
  • PI3K/AKT/mTOR signaling in cancer
  • Genomics and Chromatin Dynamics
  • Cellular Mechanics and Interactions

Their recent scholarly contributions include the following papers:

  • "The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors," 2020, PLoS ONE
  • "DNA damage causes ATM-dependent heterochromatin loss leading to nuclear softening, blebbing, and rupture," 2024, Molecular Biology of the Cell
  • "Lamin B loss in nuclear blebs is rupture dependent while increased DNA damage is rupture independent," 2025, bioRxiv (Cold Spring Harbor Laboratory)
  • "Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction," 2025, Nucleus
  • "Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration," 2023, Biochemical Journal

Frequent coauthors include Andrew D. Stephens, Mai Pho, Christopher R. Horne, Samuel N. Young, and Toby A. Dite, each collaborating on multiple publications. This collaborative work reflects a consistent engagement within a network of researchers focused on related scientific topics.

Their publications are often featured in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biochemical Journal, Molecular Cancer Research, PLoS ONE, and Molecular Biology of the Cell. bioRxiv (Cold Spring Harbor Laboratory) records the highest number of Gerard Manning's contributions.

Gerard Manning received the award of Fellow of Alfred P. Sloan Foundation in 1970, marking a historical recognition in their career.

Best Publications

  • The Protein Kinase Complement of the Human Genome

    G. Manning;D. B. Whyte;R. Martinez;T. Hunter

  • The genome of the sea urchin Strongylocentrotus purpuratus.

    Erica Sodergren;George M. Weinstock;Eric H. Davidson;R. Andrew Cameron

  • Evolution of protein kinase signaling from yeast to man.

    Gerard Manning;Gregory D Plowman;Tony Hunter;Sucha Sudarsanam

  • The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

    Nicole King;M Jody Westbrook;Susan L Young;Alan Kuo

  • The Amphimedon queenslandica genome and the evolution of animal complexity

    Mansi Srivastava;Oleg Simakov;Oleg Simakov;Jarrod Chapman;Bryony Fahey

  • The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families.

    Shibu Yooseph;Granger Sutton;Douglas B. Rusch;Aaron L Halpern

  • Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea

    C.B. Walker;J.R. De la Torre;M.G. Klotz;H. Urakawa

  • Genomic minimalism in the early diverging intestinal parasite Giardia lamblia.

    Hilary G. Morrison;Andrew G. McArthur;Frances D. Gillin;Stephen B. Aley

  • The Selaginella genome identifies genetic changes associated with the evolution of vascular plants.

    Jo Ann Banks;Tomoaki Nishiyama;Mitsuyasu Hasebe;Mitsuyasu Hasebe;John L. Bowman;John L. Bowman

  • Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote

    Jonathan A. Eisen;Robert S Coyne;Martin Wu;Dongying Wu

  • The fold of alpha-synuclein fibrils

    Marçal Vilar;Hui-Ting Chou;Thorsten Lührs;Samir K. Maji

  • A comprehensive transcriptional portrait of human cancer cell lines

    Christiaan Klijn;Steffen Durinck;Eric W Stawiski;Peter M Haverty

  • Cyclin-dependent kinases: a family portrait

    Marcos Malumbres;Edward Harlow;Tim Hunt;Tony Hunter

  • TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

    Jeremy Copp;Gerard Manning;Tony Hunter

  • Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)

    Jason E. Stajich;Jason E. Stajich;Jason E. Stajich;Sarah K. Wilke;Dag Ahrén;Chun Hang Au

  • Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.

    William Mair;Ianessa Morantte;Ana P. C. Rodrigues;Gerard Manning

  • RPN-6 determines C. elegans longevity under proteotoxic stress conditions

    David Vilchez;Ianessa Morantte;Zheng Liu;Peter M. Douglas

  • Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events

    Christos Samakovlis;Nir Hacohen;Gerard Manning;David C. Sutherland

  • The mouse kinome: Discovery and comparative genomics of all mouse protein kinases

    Sean Caenepeel;Glen Charydczak;Sucha Sudarsanam;Tony Hunter

  • Necroptosis and Inflammation

    Kim Newton;Gerard Manning

Frequent Co-Authors

Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Jack E. Dixon
Jack E. Dixon University of California, San Diego
Daniel S. Rokhsar
Daniel S. Rokhsar University of California, Berkeley
Zemin Zhang
Zemin Zhang Peking University
Bernard Henrissat
Bernard Henrissat Technical University of Denmark
Iñaki Ruiz-Trillo
Iñaki Ruiz-Trillo Pompeu Fabra University
Asaf Salamov
Asaf Salamov Lawrence Berkeley National Laboratory
Arcady Mushegian
Arcady Mushegian National Science Foundation
Joseph P. Noel
Joseph P. Noel Salk Institute for Biological Studies
Igor V. Grigoriev
Igor V. Grigoriev Lawrence Berkeley National Laboratory

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