World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
108
Citations
71997
World Ranking
5871
National Ranking
3146

Overview

Fred S. Apple is affiliated with the University of Minnesota in the United States and specializes in medicine, with a significant focus on cardiology and cardiovascular medicine. Their research spans multiple subfields including radiology, nuclear medicine and imaging, surgery, infectious diseases, and emergency medicine.

The scientist's work concentrates primarily on topics related to acute myocardial infarction research, cardiac imaging and diagnostics, coronary interventions and diagnostics, atrial fibrillation management and outcomes, cardiac electrophysiology and arrhythmias, heart failure treatment and management, and COVID-19 clinical research studies.

Frequent co-authors in their research include:

  • Paul Collinson
  • Nicholas L. Mills
  • Yader Sandoval
  • Robert H. Christenson
  • Allan S. Jaffe

They have published extensively in venues such as:

  • Clinical Chemistry
  • Clinical Chemistry and Laboratory Medicine (CCLM)
  • Circulation
  • Journal of the American College of Cardiology
  • European Heart Journal

Representative recent papers include:

  • "High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction: A Stepped-Wedge Cluster Randomized Controlled Trial" (2021, Circulation)
  • "High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain" (2022, Circulation)
  • "High-sensitivity cardiac troponin assays for cardiovascular risk stratification in the general population" (2020, European Heart Journal)
  • "Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations" (2023, Nature Medicine)
  • "Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank" (2020, Clinical Chemistry)

Best Publications

  • Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction.

    Elliott Antman;Jean-Pierre Bassand;Werner Klein;Magnus Ohman

  • Universal definition of myocardial infarction.

    Kristian Thygesen;Joseph S. Alpert;Harvey D. White;Allan S. Jaffe

  • Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction

    J. S. Alpert;E. Antman;F. Apple;P. W. Armstrong

  • Cardiac troponin I. A marker with high specificity for cardiac injury.

    Jesse E. Adams;Geza S. Bodor;Victor Davila-Roman;James A. Delmez

  • Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery

    Jeffrey L. Carson;Michael L. Terrin;Helaine Noveck;David W. Sanders

  • Ferritin: a cytoprotective antioxidant strategem of endothelium.

    György Balla;Harry S. Jacob;József Balla;M. Rosenberg

  • Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute

    Russell V. Luepker;Fred S. Apple;Robert H. Christenson;Richard S. Crow

  • National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes.

    David A. Morrow;Christopher P. Cannon;Robert L. Jesse;L. Kristin Newby

  • National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases

    Alan H.B. Wu;Fred S. Apple;W. Brian Gibler;Robert L. Jesse

  • Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays

    Fred S. Apple;Fred S. Apple;Paul O. Collinson

  • It’s Time for a Change to a Troponin Standard

    Allan S. Jaffe;Jan Ravkilde;Robert Roberts;Ulf Naslund

  • Cardiac Troponin and Outcome in Acute Heart Failure

    W. Frank Peacock;Teresa De Marco;Gregg C. Fonarow;Deborah Diercks

  • Biomarkers in acute cardiac disease: the present and the future.

    Allan S. Jaffe;Luciano Babuin;Fred S. Apple

  • Biochemical mechanisms for oxygen free radical formation during exercise.

    Bertil Sjödin;Bertil Sjödin;Ylva Hellsten Westing;Ylva Hellsten Westing;Fred S. Apple;Fred S. Apple

  • Determination of 19 Cardiac Troponin I and T Assay 99th Percentile Values from a Common Presumably Healthy Population

    Fred S. Apple;Fred S. Apple;Ranka Ler;MaryAnn M. Murakami

  • Predictive Value of Cardiac Troponin I and T for Subsequent Death in End-Stage Renal Disease

    Fred S. Apple;Mary Ann M. Murakami;Lesly A. Pearce;Charles A Herzog

  • Future Biomarkers for Detection of Ischemia and Risk Stratification in Acute Coronary Syndrome

    Fred S. Apple;Alan H.B. Wu;Johannes Mair;Jan Ravkilde

  • Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

    Heiko Johnen;Shu Lin;Tamara Kuffner;David A. Brown

  • A New Season for Cardiac Troponin Assays: It’s Time to Keep a Scorecard

    Fred S. Apple

  • Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I

    Alan H. B. Wu;Yue-Jin Feng;Robert Moore;Fred S. Apple

Frequent Co-Authors

Allan S. Jaffe
Allan S. Jaffe Mayo Clinic
Alan H.B. Wu
Alan H.B. Wu University of California, San Francisco
Robert H. Christenson
Robert H. Christenson University of Maryland, Baltimore
Nicholas L. Mills
Nicholas L. Mills University of Edinburgh
David A. Morrow
David A. Morrow Brigham and Women's Hospital
Judd E. Hollander
Judd E. Hollander Thomas Jefferson University
Christian Mueller
Christian Mueller University Hospital of Basel
David E. Newby
David E. Newby University of Edinburgh
Alan S. Maisel
Alan S. Maisel University of California, San Diego
L. Kristin Newby
L. Kristin Newby Duke University

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