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Biology and Biochemistry

D-Index
57
Citations
13242
World Ranking
13709
National Ranking
5810

Overview

Dirk van den Boom is affiliated with Sequenom in the United States and has contributed to research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans multiple subfields including Pediatrics, Perinatology and Child Health, Cancer Research, Pulmonary and Respiratory Medicine, Infectious Diseases, and Small Animals.

The scientist's work engages notably with topics such as Cancer Genomics and Diagnostics, Prenatal Screening and Diagnostics, Veterinary Oncology Research, Parvovirus B19 Infection Studies, Infectious Diseases and Mycology, Microbial Infections and Disease Research, and Fetal and Pediatric Neurological Disorders.

Dirk van den Boom has authored several peer-reviewed papers, contributing to clinical and diagnostic advancements. Key publications include:

  • Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study, 2022, PLoS ONE
  • Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs, 2021, Frontiers in Veterinary Science
  • An exploration of methods to enable equitable access to non-invasive prenatal screening, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Capillary blood collection: exploring a new method to promote noninvasive prenatal screening access, 2023, American Journal of Obstetrics and Gynecology
  • Plasma cfDNA analysis can be facilitated by membrane based filtration of whole blood regardless of additive, 2023, bioRxiv (Cold Spring Harbor Laboratory)

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Frontiers in Veterinary Science, and the American Journal of Obstetrics and Gynecology.

Dirk van den Boom has collaborated extensively with several co-authors, including Mathias Ehrich, Andi Flory, Kristina M. Kruglyak, John A. Tynan, and Nicole F. Leibman, reflecting interdisciplinary cooperation within the fields of prenatal screening, cancer diagnostics, and veterinary oncology.

Best Publications

  • Oct4-induced pluripotency in adult neural stem cells

    Jeong Beom Kim;Vittorio Sebastiano;Guangming Wu;Marcos J. Araúzo-Bravo

  • Dna Sequencing of Maternal Plasma to Detect Down Syndrome: An International Clinical Validation Study

    Glenn E. Palomaki;Edward M. Kloza;Geralyn M. Lambert-Messerlian;James E. Haddow

  • Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

    Mathias Ehrich;Matthew R. Nelson;Patrick Stanssens;Marc Zabeau

  • DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study

    Glenn E. Palomaki;Cosmin Deciu;Edward M. Kloza;Geralyn M. Lambert-Messerlian

  • Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting

    Mathias Ehrich;Cosmin Deciu;Tricia Zwiefelhofer;John A. Tynan

  • Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale.

    Christopher D Herring;Christopher D Herring;Christopher D Herring;Anu Raghunathan;Anu Raghunathan;Anu Raghunathan;Christiane Honisch;Trina Patel

  • MALDI-TOF mass spectrometry: a versatile tool for high-performance DNA analysis.

    Christian Jurinke;Paul Oeth;Dirk van den Boom

  • Automated Genotyping Using the DNA MassArray™ Technology

    Christian Jurinke;Dirk van den Boom;Charles R. Cantor;Hubert Köster

  • A strategy for rapid and efficient DNA sequencing by mass spectrometry

    Hubert Köster;Kai Tang;Dong Jing Fu;Andreas Braun

  • Noninvasive prenatal detection of sex chromosomal aneuploidies by sequencing circulating cell‐free DNA from maternal plasma

    Amin R. Mazloom;Željko Džakula;Paul Oeth;Huiquan Wang

  • The use of MassARRAY technology for high throughput genotyping.

    Christian Jurinke;Dirk van den Boom;Charles R. Cantor;Hubert Köster

  • DNA sequencing of maternal plasma to identify Down syndrome and other trisomies in multiple gestations.

    Jacob A. Canick;Edward M. Kloza;Geralyn M. Lambert-Messerlian;James E. Haddow

  • Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts

    Sung K. Kim;Gregory Hannum;Jennifer Geis;John Tynan

  • Noninvasive prenatal screening for fetal trisomies 21, 18, 13 and the common sex chromosome aneuploidies from maternal blood using massively parallel genomic sequencing of DNA.

    Richard P. Porreco;Thomas J. Garite;Kimberly Maurel;Barbara Marusiak

  • Base-specific fragmentation of amplified 16S rRNA genes analyzed by mass spectrometry: A tool for rapid bacterial identification

    Friedrich von Wintzingerode;Sebastian Böcker;Cord Schlötelburg;Norman H. L. Chiu

  • Quantification of Fetal DNA by Use of Methylation-Based DNA Discrimination

    Anders O.H. Nygren;Jarrod Dean;Taylor J. Jensen;Selena Kruse

  • Association testing by DNA pooling: An effective initial screen

    Aruna Bansal;Dirk van den Boom;Stefan Kammerer;Christiane Honisch

  • Quantitative DNA methylation predicts survival in adult acute myeloid leukemia.

    Lars Bullinger;Mathias Ehrich;Konstanze Döhner;Richard F. Schlenk

  • Optimizing blood collection, transport and storage conditions for cell free DNA increases access to prenatal testing

    David Wong;Sharmili Moturi;Vach Angkachatchai;Reinhold Mueller

  • Detection of Fetal Subchromosomal Abnormalities by Sequencing Circulating Cell-Free DNA from Maternal Plasma

    Chen Zhao;John Tynan;Mathias Ehrich;Gregory Hannum

Frequent Co-Authors

Hubert Köster
Hubert Köster Sequenom (United States)
Charles R. Cantor
Charles R. Cantor Boston University
Glenn E. Palomaki
Glenn E. Palomaki Brown University
James E. Haddow
James E. Haddow Brown University
Sebastian Böcker
Sebastian Böcker Friedrich Schiller University Jena
Matthew R. Nelson
Matthew R. Nelson GlaxoSmithKline (United Kingdom)
Eleftherios P. Diamandis
Eleftherios P. Diamandis Mount Sinai Hospital
Stanley F. Nelson
Stanley F. Nelson University of California, Los Angeles
Marc Zabeau
Marc Zabeau Ghent University
Bernhard O. Palsson
Bernhard O. Palsson University of California, San Diego

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