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Microbiology

D-Index
53
Citations
9093
World Ranking
4117
National Ranking
1596

Overview

Carlos J. Orihuela is affiliated with the University of Alabama at Birmingham in the United States. Their research primarily focuses on medicine, with significant contributions in epidemiology, public health, pulmonary and respiratory medicine, immunology, and microbiology.

The scientist has concentrated on key topics within the medical field, including:

  • Pneumonia and Respiratory Infections
  • Respiratory viral infections research
  • Streptococcal Infections and Treatments
  • Bacterial Infections and Vaccines
  • Influenza Virus Research Studies
  • Interferon and immune responses
  • Bacterial biofilms and quorum sensing

Some of the recent publications by Carlos J. Orihuela cover diverse aspects of infectious diseases and host-pathogen interactions. Notable works include:

  • Sugar-Coated Killer: Serotype 3 Pneumococcal Disease (2020), published in Frontiers in Cellular and Infection Microbiology
  • COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation (2023), published in Critical Care
  • Major Adverse Cardiovascular Events During Invasive Pneumococcal Disease Are Serotype Dependent (2020), published in Clinical Infectious Diseases
  • An in vivo atlas of host-pathogen transcriptomes during Streptococcus pneumoniae colonization and disease (2020), published in Proceedings of the National Academy of Sciences
  • Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis (2020), published in Cell Reports

Frequent co-authors collaborating with Carlos J. Orihuela include:

  • Eriel Martínez
  • Hervé Tettelin
  • Hansol Im
  • Ashleigh N. Riegler
  • Katherine L. Kruckow

The scientist often publishes in specific venues, which include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • mBio
  • Frontiers in Cellular and Infection Microbiology
  • Cell Reports
  • Infection and Immunity

Best Publications

  • Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

    Richard A. Miller;Richard A. Miller;David E. Harrison;C. M. Astle;Joseph A. Baur

  • Tissue-Specific Contributions of Pneumococcal Virulence Factors to Pathogenesis

    Carlos J. Orihuela;Geli Gao;Kevin P. Francis;Jun Yu

  • Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

    Carlos J. Orihuela;Jafar Mahdavi;Justin Thornton;Beth Mann

  • Microarray Analysis of Pneumococcal Gene Expression during Invasive Disease

    Carlos J. Orihuela;Jana N. Radin;Jack E. Sublett;Geli Gao

  • Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.

    Norberto González-Juarbe;Norberto González-Juarbe;Ryan Paul Gilley;Cecilia Anahí Hinojosa;Cecilia Anahí Hinojosa;Kelley Margaret Bradley

  • Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells.

    Liquan Xue;Stephan W Morris;Stephan W Morris;Carlos Orihuela;Elaine Tuomanen

  • Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function

    Armand O. Brown;Beth Mann;Geli Gao;Jane S. Hankins

  • The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms

    Carlos J. Sanchez;Pooja Shivshankar;Kim Stol;Samuel Trakhtenbroit

  • Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease

    Caroline Obert;Jack Sublett;Deepak Kaushal;Ernesto Hinojosa

  • NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis

    David Pajuelo;Norberto Gonzalez-Juarbe;Uday Tak;Jim Sun

  • β-Arrestin 1 Participates in Platelet-Activating Factor Receptor-Mediated Endocytosis of Streptococcus pneumoniae

    Jana N. Radin;Carlos J. Orihuela;Gopal Murti;Christopher Guglielmo

  • Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza.

    Matthew W Smith;Jeffrey E Schmidt;Jerold E Rehg;Carlos J Orihuela

  • The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells.

    Pooja Shivshankar;Carlos Sanchez;Lloyd F. Rose;Carlos J. Orihuela

  • Age-Associated Inflammation and Toll-Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia

    Ernesto Hinojosa;Angela R. Boyd;Carlos J. Orihuela

  • Streptococcus pneumoniae: Invasion and Inflammation

    Allister J. Loughran;Carlos J. Orihuela;Elaine I. Tuomanen

  • Severe pneumococcal pneumonia causes acute cardiac toxicity and subsequent cardiac remodeling

    Luis F. Reyes;Luis F. Reyes;Marcos I. Restrepo;Marcos I. Restrepo;Cecilia A. Hinojosa;Cecilia A. Hinojosa;Nilam J. Soni;Nilam J. Soni

  • Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

    Pooja Shivshankar;Angela Rodriguez Boyd;Claude Jourdan Le Saux;I-Tien Yeh

  • Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production

    Carlos J. Sanchez;Nikhil Kumar;Anel Lizcano;Pooja Shivshankar

  • Incidence of Cardiovascular Events After Hospital Admission for Pneumonia

    Theodore W. Perry;Mary Jo V. Pugh;Grant W. Waterer;Grant W. Waterer;Brandy Nakashima

  • Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia.

    Angela R. Boyd;Pooja Shivshankar;Shoulei Jiang;Michael T. Berton

  • Virulence in Mice of Pneumococcal Clonal Types with Known Invasive Disease Potential in Humans

    Andreas Sandgren;Barbara Albiger;Carlos J. Orihuela;Elaine Tuomanen

Frequent Co-Authors

Elaine I. Tuomanen
Elaine I. Tuomanen St. Jude Children's Research Hospital
Antonio Anzueto
Antonio Anzueto The University of Texas Health Science Center at San Antonio
Hervé Tettelin
Hervé Tettelin University of Maryland, Baltimore
Moon H. Nahm
Moon H. Nahm University of Alabama at Birmingham
Stefano Aliberti
Stefano Aliberti Humanitas University
James D. Chalmers
James D. Chalmers University of Dundee
Charles S. Dela Cruz
Charles S. Dela Cruz Yale University
Peter J. Murray
Peter J. Murray Max Planck Society
Demin Wang
Demin Wang Medical College of Wisconsin
Deepak Kaushal
Deepak Kaushal Texas Biomedical Research Institute

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