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Molecular Biology

D-Index
44
Citations
4911
World Ranking
2939
National Ranking
1401

Overview

Bin Zhan is affiliated with Baylor College of Medicine in the United States. Their research contributions are primarily situated within the fields of Medicine and Immunology and Microbiology, with a focus on various subfields including Infectious Diseases, Parasitology, Molecular Biology, Ecology, and Immunology.

The scientist has published extensively on topics related to Parasites and Host Interactions, SARS-CoV-2 and COVID-19 Research, Parasite Biology and Host Interactions, Parasitic Diseases Research and Treatment, vaccines and immunoinformatics approaches, Bacillus and Francisella bacterial research, and Trypanosoma species research and implications.

Frequent coauthors in Bin Zhan's research include María Elena Bottazzi, Peter J. Hotez, Ulrich Strych, Zhuyun Liu, and Wen-Hsiang Chen.

Their research is often published in specialized journals and venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Vaccines, Frontiers in Cellular and Infection Microbiology, and Parasites & Vectors.

Some recent papers authored by Bin Zhan include:

  • SARS-CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice, 2021, Human Vaccines & Immunotherapeutics
  • Excretory/Secretory Products From Trichinella spiralis Adult Worms Attenuated DSS-Induced Colitis in Mice by Driving PD-1-Mediated M2 Macrophage Polarization, 2020, Frontiers in Immunology
  • A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates, 2021, Science Immunology
  • Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate, 2021, Biochimica et Biophysica Acta (BBA) - General Subjects
  • Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1, 2021, Applied Microbiology and Biotechnology

Best Publications

  • Genome of the human hookworm Necator americanus

    Yat T Tang;Xin Gao;Bruce A Rosa;Sahar Abubucker

  • Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals

    Jeffrey Bethony;Alex Loukas;Michael Smout;Simon Brooker

  • Emerging Patterns of Hookworm Infection: Influence of Aging on the Intensity of Necator Infection in Hainan Province, People's Republic of China

    Jeffrey Bethony;Jizhang Chen;Shaoxiong Lin;Shuhua Xiao

  • X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infection

    Oluwatoyin A. Asojo;Gaddam Goud;Kajari Dhar;Alex Loukas;Alex Loukas

  • Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome

    Shibo Jiang;Maria Elena Bottazzi;Lanying Du;Sara Lustigman

  • Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

    Eric Dumonteil;Maria Elena Bottazzi;Bin Zhan;Michael J Heffernan

  • Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative.

    Peter J Hotez;Bin Zhan;Jeffrey M Bethony;Alex Loukas

  • Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs.

    Alex Loukas;Jeffrey M Bethony;Susana Mendez;Ricardo T Fujiwara

  • Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

    Severine Navarro;Darren A. Pickering;Ivana B. Ferreira;Linda Jones

  • Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum.

    Gaddam Narsa Goud;Bin Zhan;Kashinath Ghosh;Alex Loukas

  • Ancylostoma caninum MTP-1, an Astacin-Like Metalloprotease Secreted by Infective Hookworm Larvae, Is Involved in Tissue Migration

    Angela L. Williamson;Sara Lustigman;Yelena Oksov;Vehid Deumic

  • Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

    Wen Hsiang Chen;Lanying Du;Shivali M. Chag;Cuiqing Ma

  • Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum.

    Bin Zhan;Yueyuan Liu;Mahnaz Badamchian;Angela Williamson

  • Vaccination with a Paramyosin-Based Multi-Epitope Vaccine Elicits Significant Protective Immunity against Trichinella spiralis Infection in Mice.

    Yuan Gu;Ximeng Sun;Bo Li;Jingjing Huang

  • An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

    Mark S. Pearson;Jeffrey M. Bethony;Darren A. Pickering;Luciana M. de Oliveira

  • Vaccination of Dogs with a Recombinant Cysteine Protease from the Intestine of Canine Hookworms Diminishes the Fecundity and Growth of Worms

    Alex Loukas;Alex Loukas;Jeffrey M. Bethony;Angela L. Williamson;Gaddam N. Goud

  • Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum.

    Bin Zhan;Sen Liu;Samirah Perally;Jian Xue

  • The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus.

    Shuhua Xiao;Bin Zhan;Jian Xue;Gaddam Narsa Goud

  • Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials.

    Gaddam Narsa Goud;Maria Elena Bottazzi;Bin Zhan;Susana Mendez

  • Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion

    Angela L. Williamson;Angela L. Williamson;Paul J. Brindley;Giovanni Abbenante;Bennett J. D. Datu

Frequent Co-Authors

Peter J. Hotez
Peter J. Hotez Baylor College of Medicine
Maria Elena Bottazzi
Maria Elena Bottazzi Baylor College of Medicine
Alex Loukas
Alex Loukas James Cook University
Jeffrey M. Bethony
Jeffrey M. Bethony George Washington University
Sara Lustigman
Sara Lustigman New York Blood Center
Ricardo Toshio Fujiwara
Ricardo Toshio Fujiwara Universidade Federal de Minas Gerais
David Abraham
David Abraham University College London
Thomas R. Klei
Thomas R. Klei Louisiana State University
Eric Dumonteil
Eric Dumonteil Tulane University
Shibo Jiang
Shibo Jiang Fudan University

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