Alan J. Barrett

What is he best known for?

The fields of study he is best known for:

• Enzyme
• Gene
• Amino acid

Alan J. Barrett spends much of his time researching Biochemistry, Chromatography, Cysteine, Proteolytic enzymes and Molecular biology. All of his Biochemistry and Cathepsin B and Papain investigations are sub-components of the entire Biochemistry study. His work carried out in the field of Papain brings together such families of science as Endopeptidase, Reagent and Sulfation.

His Chromatography research incorporates themes from Glycosaminoglycan, Gel electrophoresis and Substrate. The various areas that Alan J. Barrett examines in his Proteolytic enzymes study include MEROPS, Peptide Hydrolases, A protein and Protein species. His Molecular biology research is multidisciplinary, incorporating perspectives in Astacin and Thimet oligopeptidase.

His most cited work include:

• Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue (2973 citations)
• Handbook of proteolytic enzymes (2280 citations)
• MEROPS: the peptidase database (2154 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Biochemistry, Enzyme, Molecular biology, Cysteine and Chromatography. His work in the fields of Biochemistry, such as Peptide sequence, Papain and Cathepsin B, intersects with other areas such as Cystatin and Legumain. In his study, which falls under the umbrella issue of Enzyme, Amino acid and Thimet oligopeptidase is strongly linked to Stereochemistry.

He has researched Molecular biology in several fields, including Proteolytic enzymes and Cathepsin D. As part of the same scientific family, Alan J. Barrett usually focuses on Proteolytic enzymes, concentrating on Computational biology and intersecting with Peptidase Inhibitors. The Chromatography study combines topics in areas such as Reagent, Affinity chromatography, Chymopapain and Sepharose.

He most often published in these fields:

• Biochemistry (67.05%)
• Enzyme (23.86%)
• Molecular biology (19.32%)

What were the highlights of his more recent work (between 1999-2018)?

• Biochemistry (67.05%)
• Proteolytic enzymes (11.93%)
• MEROPS (6.25%)

In recent papers he was focusing on the following fields of study:

Alan J. Barrett mainly investigates Biochemistry, Proteolytic enzymes, MEROPS, Peptide sequence and Stereochemistry. In the field of Biochemistry, his study on Cysteine, Protease and Serine overlaps with subjects such as Legumain and Clan. His Proteolytic enzymes research includes elements of Genome, Eukaryote, Computational biology and Sequence alignment.

His studies in MEROPS integrate themes in fields like Conserved sequence and Bioinformatics. His Peptide sequence research incorporates elements of Residue, Molecular biology and In vivo. His study on Stereochemistry also encompasses disciplines like

• Chymotrypsin which intersects with area such as Cysteine protease and Cathepsin B,
• Amino acid that connect with fields like Thimet oligopeptidase,
• Proteases that connect with fields like Cell biology.

Between 1999 and 2018, his most popular works were:

• MEROPS: the database of proteolytic enzymes, their substrates and inhibitors (1194 citations)
• Evolutionary families of peptidase inhibitors. (486 citations)
• The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database (482 citations)

In his most recent research, the most cited papers focused on:

• Enzyme
• Gene
• Amino acid

His scientific interests lie mostly in Biochemistry, Proteolytic enzymes, MEROPS, Peptide sequence and Cleavage. His study looks at the relationship between Biochemistry and topics such as Computational biology, which overlap with Peptidase Inhibitors. Alan J. Barrett frequently studies issues relating to Clostripain and Proteolytic enzymes.

His multidisciplinary approach integrates MEROPS and Database in his work. His studies deal with areas such as Serine, Molecular mass, Complementary DNA, Molecular biology and Alanine as well as Asparagine. His Cysteine study combines topics in areas such as Papain, PA clan and Gelatinase A.