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Medicine

D-Index
85
Citations
22327
World Ranking
14750
National Ranking
41

Overview

Adair R.S. Santos was a researcher affiliated with the Universidade Federal de Santa Catarina in Brazil. Their body of work spanned several areas within medicine and neuroscience, with a focus on understanding molecular and physiological mechanisms related to pain, stress, and natural compound pharmacology.

Their research covered multiple main fields of study, including:

  • Medicine
  • Neuroscience

Within these broader fields, Santos contributed to several subfields such as:

  • Physiology
  • Molecular Biology
  • Pharmacology
  • Plant Science
  • Cellular and Molecular Neuroscience

The researcher conducted work on a variety of topics, often exploring the mechanisms and treatment of pain, stress responses, and cannabinoid pharmacology. The main topics of their work included:

  • Pain Mechanisms and Treatments
  • Stress Responses and Cortisol
  • Acupuncture Treatment Research Studies
  • Cannabis and Cannabinoid Research
  • Natural Compound Pharmacology Studies
  • Tryptophan and Brain Disorders
  • Ion Channels and Receptors

Several venues frequently published Santos's work, including:

  • Biomolecules
  • Metabolic Brain Disease
  • Journal of Natural Products
  • Frontiers in Neuroscience
  • Cellular and Molecular Neurobiology

Their recent publications featured the following articles:

  • Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor (2020), Biomolecules
  • Citral Inhibits the Inflammatory Response and Hyperalgesia in Mice: The Role of TLR4, TLR2/Dectin-1, and CB2 Cannabinoid Receptor/ATP-Sensitive K+ Channel Pathways (2020), Journal of Natural Products
  • Inosine as a Tool to Understand and Treat Central Nervous System Disorders: A Neglected Actor? (2021), Frontiers in Neuroscience
  • Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model (2020), Cellular and Molecular Neurobiology
  • Protocolos para tratamento psicológico em pandemias: as demandas em saúde mental produzidas pela Covid-19 (2020), Debates em Psiquiatria

Throughout their career, Santos collaborated frequently with several co-authors, including:

  • Luiz Fernando Freire Royes
  • Rafael C. Dutra
  • Morgana Duarte da Silva
  • Elaine Cristina Dalazen Gonçalves
  • Fernando da Silva Fiorin

Santos's work contributed to understanding the complex interactions within neuropharmacology related to pain and inflammation as well as the effects of natural compounds on nervous system disorders. Their research emphasized cellular receptors, ion channels, and the cannabinoid system as key mechanisms in disease models and treatment pathways.

Best Publications

  • A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential.

    João B. Calixto;Adair R. S. Santos;Valdir Cechinel Filho;Rosendo A. Yunes

  • Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules.

    João B. Calixto;Maria M. Campos;Michel F. Otuki;Adair R. S. Santos

  • Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives.

    Rafael C. Dutra;Maria M. Campos;Adair R.S. Santos;João B. Calixto

  • Naturally occurring antinociceptive substances from plants.

    João B. Calixto;Alessandra Beirith;Juliano Ferreira;Adair R. S. Santos

  • Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB).

    João B. Calixto;Michel F. Otuki;Adair R. S. Santos

  • Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw.

    Alessandra Beirith;Adair R.S Santos;João B Calixto

  • Depressive-like behavior induced by tumor necrosis factor-α in mice

    Manuella P. Kaster;Vinícius M. Gadotti;Vinícius M. Gadotti;João B. Calixto;Adair R.S. Santos

  • Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems.

    Daniele G. Machado;Luis E.B. Bettio;Mauricio P. Cunha;Adair R.S. Santos

  • Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling

    Aderbal S. Aguiar;Adalberto A. Castro;Eduardo L. Moreira;Viviane Glaser

  • Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-d-aspartate receptors and the l-arginine-nitric oxide pathway

    Michela Mantovani;Roberto Pértile;João B. Calixto;Adair R.S. Santos

  • Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice

    A.R.S Santos;J.B Calixto

  • Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus.

    Ana Lúcia S. Rodrigues;Gisele L. da Silva;Andreza S. Mateussi;Elizabeth S. Fernandes

  • Agmatine produces antidepressant-like effects in two models of depression in mice.

    Andrea D E Zomkowski;Luciana Hammes;Jaime Lin;João Batista Calixto

  • Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice

    Raquel M. Teixeira;Adair R.S. Santos;Sandro J. Ribeiro;João B. Calixto

  • Analgesic Effects of Callus Culture Extracts from Selected Species of Phyllanthus in Mice

    Adair R. S. Santos;Valdir C. Filho;Rivaldo Niero;Ana M. Viana

  • Involvement of NMDA receptors and L-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice

    Angelo Oscar Rosa;Jaime Lin;João Batista Calixto;Adair Roberto S. Santos

  • Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action

    Alessandra Beirith;Adair R.S Santos;Ana L.S Rodrigues;Tânia B Creczynski-Pasa

  • Antinociceptive Properties of Mixture of α-Amyrin and β-Amyrin Triterpenes: Evidence for Participation of Protein Kinase C and Protein Kinase A Pathways

    Michel F Otuki;Juliano Ferreira;Fabiana V Lima;Cristiane Meyre-Silva

  • Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways.

    Flavia Carla Meotti;Ana Paula Luiz;Moacir Geraldo Pizzolatti;Candida A. L. Kassuya

  • A Review of the Plants of the Genus Phyllanthus: Their Chemistry, Pharmacology, and Therapeutic Potential

    J. B. Calixto;A. R. S. Santos;V. Cechinel Filho;R. A. Yunes

Frequent Co-Authors

João B. Calixto
João B. Calixto Universidade Federal de Santa Catarina
Ana Lúcia S. Rodrigues
Ana Lúcia S. Rodrigues Universidade Federal de Santa Catarina
Moacir Geraldo Pizzolatti
Moacir Geraldo Pizzolatti Universidade Federal de Santa Catarina
Rosendo A. Yunes
Rosendo A. Yunes Universidade Federal de Santa Catarina
Juliano Ferreira
Juliano Ferreira Universidade Federal de Santa Maria
Marcello Iacomini
Marcello Iacomini Federal University of Paraná
Josiane Budni
Josiane Budni Universidade do Extremo Sul Catarinense
Guilherme L. Sassaki
Guilherme L. Sassaki Federal University of Paraná
Philip A.J. Gorin
Philip A.J. Gorin Federal University of Paraná
Carlos Fernando Mello
Carlos Fernando Mello Universidade Federal de Santa Maria

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