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A. L. W. F. Eddleston

A. L. W. F. Eddleston

D-Index & Metrics

Immunology

D-Index
60
Citations
13739
World Ranking
3320
National Ranking
285

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Antibody
  • Antigen

A. L. W. F. Eddleston focuses on Immunology, Hepatitis, Antigen, Antibody and Virus. His Immunology research is multidisciplinary, incorporating perspectives in Chronic liver disease, Liver cell and Lipoprotein. A. L. W. F. Eddleston has researched Hepatitis in several fields, including Gastroenterology, Hepatitis B and HBsAg.

His studies in Antigen integrate themes in fields like Cell mediated immunity and Immune system. His study looks at the relationship between Antibody and topics such as Virology, which overlap with Molecular biology, Cytotoxic T cell and Cytotoxicity. The various areas that A. L. W. F. Eddleston examines in his Virus study include Suppressor, Cell type and Apoptosis.

His most cited work include:

  • International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis (2162 citations)
  • Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: Evidence that T cells are directed against HBV core antigen expressed on hepatocytes (335 citations)
  • INADEQUATE ANTIBODY RESPONSE TO HBAg OR SUPPRESSOR T-CELL DEFECT IN DEVELOPMENT OF ACTIVE CHRONIC HEPATITIS (236 citations)

What are the main themes of his work throughout his whole career to date?

A. L. W. F. Eddleston mainly investigates Immunology, Hepatitis, Antigen, Internal medicine and Antibody. His work investigates the relationship between Immunology and topics such as Virology that intersect with problems in Molecular biology. His Hepatitis research includes elements of Chronic liver disease, Cirrhosis, Cytotoxic T cell and Cytotoxicity.

His Antigen research is multidisciplinary, relying on both Cell mediated immunity, Pathology, Sensitization and Primary biliary cirrhosis. His Internal medicine study incorporates themes from Gastroenterology and Endocrinology. His Antibody study also includes

  • Hepatocyte that connect with fields like Lipoprotein,
  • Liver disease that connect with fields like Pathogenesis.

He most often published in these fields:

  • Immunology (72.90%)
  • Hepatitis (41.94%)
  • Antigen (27.74%)

What were the highlights of his more recent work (between 1986-2011)?

  • Immunology (72.90%)
  • Virology (19.35%)
  • Hepatitis B virus (18.71%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Immunology, Virology, Hepatitis B virus, Hepatitis and Virus. His work in Virology covers topics such as Liver disease which are related to areas like Immunopathology, Immunogenetics and Major histocompatibility complex. His Hepatitis B virus research integrates issues from Interleukin and Interferon.

Particularly relevant to Autoimmune hepatitis is his body of work in Hepatitis. A. L. W. F. Eddleston combines subjects such as Dermatology, Guideline, Overlap syndrome and MEDLINE with his study of Autoimmune hepatitis. His research in Hepatitis B tackles topics such as HBcAg which are related to areas like Liver cell, Antigen and Monoclonal.

Between 1986 and 2011, his most popular works were:

  • International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis (2162 citations)
  • Detection of genomic and intermediate replicative strands of hepatitis C virus in liver tissue by in situ hybridization. (106 citations)
  • Spontaneous production of tumour necrosis factor α and interleukin-1β during interferon-α treatment of chronic HBV infection (97 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Antibody
  • Immune system

His scientific interests lie mostly in Immunology, Virus, Hepatitis B virus, Interleukin and Peripheral blood mononuclear cell. He interconnects Dermatology, Guideline, Cell type and MEDLINE in the investigation of issues within Immunology. The study incorporates disciplines such as Cancer, Suppressor, Apoptosis and Pathogenesis in addition to Virus.

His Hepatitis B virus study integrates concerns from other disciplines, such as Lymphocyte proliferation, Lipopolysaccharide, Interferon, Lymphokine and Interleukin 2. His biological study spans a wide range of topics, including Interferon alfa, Alpha interferon and HBeAg.

Best Publications

  • International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis

    F. Alvarez;P. A. Berg;F. B. Bianchi;L. Bianchi

  • Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: Evidence that T cells are directed against HBV core antigen expressed on hepatocytes

    M Mondelli;G M Vergani;A Alberti;D Vergani

  • INADEQUATE ANTIBODY RESPONSE TO HBAg OR SUPPRESSOR T-CELL DEFECT IN DEVELOPMENT OF ACTIVE CHRONIC HEPATITIS

    A.L.W.F Eddleston;Roger Williams

  • Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis.

    Diego Vergani;Giorgina Mieli-Vergani;Alfredo Alberti;James Neuberger

  • Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis.

    Donald M. Jensen;Ian G. McFarlane;Bernard S. Portmann;A. L. W. F. Eddleston

  • Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis

    Derek G. Doherty;Peter T. Donaldson;James A. Underhill;J. Mark Farrant

  • ANTIBODY-DEPENDENT CELL-MEDIATED (K CELL) CYTOTOXICITY AGAINST ISOLATED HEPATOCYTES IN CHRONIC ACTIVE HEPATITIS

    A.M.G. Cochrane;A.D. Thomson;A. Moussouros;A.L.W.F. Eddleston

  • Purification and characterization of human liver-specific membrane lipoprotein (LSP).

    I G McFarlane;B M Wojcicka;G M Zucker;A L Eddleston

  • Hepatocellular carcinoma in Great Britain: influence of age, sex, HBsAg status, and aetiology of underlying cirrhosis.

    P J Johnson;N Krasner;B Portmann;A L Eddleston

  • CELL-MEDIATED IMMUNITY TO A HUMAN LIVER-SPECIFIC ANTIGEN IN PATIENTS WITH ACTIVE CHRONIC HEPATITIS AND PRIMARY BILIARY CIRRHOSIS

    Joanna Miller;ChristineG Mitchell;A.L.W.F Eddleston;M.G.M Smith

  • Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.

    A Theodossi;A L Eddleston;R Williams

  • Histocompatibility antigens, autoantibodies, and immunoglobulins in alcoholic liver disease.

    R J Bailey;N Krasner;A L Eddleston;R Williams

  • Detection of genomic and intermediate replicative strands of hepatitis C virus in liver tissue by in situ hybridization.

    K. T. Nouri Aria;R. Sallie;D. Sangar;G. J. M. Alexander

  • Mechanisms of liver cell injury in acute and chronic hepatitis B.

    Mario Mondelli;Adrian L. W. F. Eddleston

  • Relationship Between Expression of Hepatitis B Virus Antigens in Isolated Hepatocytes and Autologous Lymphocyte Cytotoxicity in Patients with Chronic Hepatitis B Virus Infection

    Nikolai V. Naumov;Mario Mondelli;Graeme J. M. Alexander;Richard S. Tedder

  • e Antigen-antibody system as indicator of liver damage in patients with hepatitis-B antigen.

    N. El Sheikh;I. L. Woolf;R. M. Galbraith;A. L. W. F. Eddleston

  • Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis.

    G M Vergani;D Vergani;P J Jenkins;B Portmann

  • Amino acid substitutions at position 38 of the DRβ polypeptide confer susceptibility to and protection from primary sclerosing cholangitis

    J. Mark Farrant;Derek G. Doherty;Peter T. Donaldson;Robert W. Vaughan

  • Spontaneous production of tumour necrosis factor α and interleukin-1β during interferon-α treatment of chronic HBV infection

    H.M. Daniels;A.L.W.F. Eddleston;G.J.M. Alexander;R. Williams

  • Histocompatibility Antigens in Active Chronic Hepatitis and Primary Biliary Cirrhosis

    R. M. Galbraith;A. L. W. F. Eddleston;M. G. M. Smith;Roger Williams

Frequent Co-Authors

Roger Williams
Roger Williams Foundation for Liver Research
Mario U. Mondelli
Mario U. Mondelli University of Pavia
Giorgina Mieli-Vergani
Giorgina Mieli-Vergani King's College London
Alfredo Alberti
Alfredo Alberti University of Padua
Diego Vergani
Diego Vergani King's College London
Philip J. Johnson
Philip J. Johnson University of Liverpool
Peter T. Donaldson
Peter T. Donaldson University of Newcastle Australia
Derek G. Doherty
Derek G. Doherty Trinity College Dublin
Andrew J.H. Smith
Andrew J.H. Smith University of Edinburgh
Jay H. Hoofnagle
Jay H. Hoofnagle National Institutes of Health

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Best Scientists Citing A. L. W. F. Eddleston