World's Best Scientists 2026 revealed!

D-Index & Metrics

Engineering and Technology

D-Index
61
Citations
14645
World Ranking
2025
National Ranking
646

Overview

Zhen Xu is affiliated with the University of Michigan-Ann Arbor in the United States and has contributed extensively to the fields of Medicine and Engineering, with a particular focus on Biomedical Engineering and Radiology, Nuclear Medicine and Imaging. Their research spans diverse subfields including Materials Chemistry, Oncology, and Hepatology.

The primary focus of Zhen Xu's work lies in ultrasound-based biomedical applications, including hyperthermia, tissue ablation, imaging, and diagnostic techniques. Major topics of research covered by Xu include ultrasound and hyperthermia applications, photoacoustic and ultrasonic imaging, ultrasound and cavitation phenomena, ultrasound imaging and elastography, hepatocellular carcinoma treatment and prognosis, spectroscopy techniques in biomedical and chemical research, and venous thromboembolism diagnosis and management.

Xu has published a significant number of papers in multiple scientific journals, with frequent contributions to Ultrasound in Medicine & Biology, The Journal of the Acoustical Society of America, IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, International Journal of Hyperthermia, and Physics in Medicine and Biology.

Notable recent publications authored or co-authored by Zhen Xu include:

  • Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound (2021, International Journal of Hyperthermia)
  • Green Biosynthesized Silver Nanoparticles With Aqueous Extracts of Ginkgo Biloba Induce Apoptosis via Mitochondrial Pathway in Cervical Cancer Cells (2020, Frontiers in Oncology)
  • Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound (2024, Annual Review of Biomedical Engineering)

Other recent influential papers connected to Xu's research community include:

  • Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy (2020, Journal for ImmunoTherapy of Cancer)
  • First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study (2022, International Journal of Hyperthermia)

Collaborative efforts are a prominent feature of Xu's research, with frequent co-authors including Timothy L. Hall, Jonathan R. Sukovich, Fred T. Lee, Timothy J. Ziemlewicz, and Clifford S. Cho, indicating a consistent collaborative network supporting advancements in ultrasound technology and therapeutic applications.

Best Publications

  • Assessment of landslide susceptibility on the natural terrain of Lantau Island, Hong Kong

    FC Dai;CF Lee;J Li;ZW Xu

  • Controlled ultrasound tissue erosion

    Zhen Xu;A. Ludomirsky;L.Y. Eun;T.L. Hall

  • Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration

    Qian Feng;Kongchang Wei;Sien Lin;Zhen Xu

  • Cavitation clouds created by shock scattering from bubbles during histotripsy.

    Adam D. Maxwell;Tzu Yin Wang;Charles A. Cain;J. Brian Fowlkes

  • Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications

    Vera A. Khokhlova;J. Brian Fowlkes;William W. Roberts;George R. Schade

  • Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials

    Adam D. Maxwell;Charles A. Cain;Timothy L. Hall;J. Brian Fowlkes

  • Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.

    Zhen Xu;Timothy L. Hall;Eli Vlaisavljevich;Fred T. Lee

  • NONINVASIVE THROMBOLYSIS USING PULSED ULTRASOUND CAVITATION THERAPY - HISTOTRIPSY

    Adam D. Maxwell;Charles A. Cain;Alexander P. Duryea;Lingqian Yuan

  • Pulsed cavitational ultrasound therapy

    Charles A. Cain;Zhen Xu;J. Brian Fowlkes;Timothy L. Hall

  • Carbon-Nanotube Optoacoustic Lens for Focused Ultrasound Generation and High-Precision Targeted Therapy

    Hyoung Won Baac;Hyoung Won Baac;Jong G. Ok;Adam Maxwell;Kyu Tae Lee

  • Controlled ultrasound tissue erosion: The role of dynamic interaction between insonation and microbubble activity

    Zhen Xu;J. Brian Fowlkes;Edward D. Rothman;Albert M. Levin

  • Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy.

    Shibin Qu;Tejaswi Worlikar;Amy E Felsted;Anutosh Ganguly

  • Image-guided non-invasive ultrasound liver ablation using histotripsy: feasibility study in an in vivo porcine model.

    Eli Vlaisavljevich;Yohan Kim;Steven Allen;Gabe Owens

  • First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study

    Unknown

  • Effects of Ultrasound Frequency and Tissue Stiffness on the Histotripsy Intrinsic Threshold for Cavitation

    Eli Vlaisavljevich;Kuang Wei Lin;Adam Maxwell;Matthew T. Warnez

  • Noninvasive Treatment of Deep Venous Thrombosis Using Pulsed Ultrasound Cavitation Therapy (Histotripsy) in a Porcine Model

    Adam D. Maxwell;Gabe Owens;Hitinder S. Gurm;Kimberly Ives

  • Histotripsy beyond the intrinsic cavitation threshold using very short ultrasound pulses: microtripsy

    Kuang-Wei Lin;Yohan Kim;Adam D. Maxwell;Tzu-Yin Wang

  • Effects of tissue mechanical properties on susceptibility to histotripsy-induced tissue damage

    Eli Vlaisavljevich;Yohan Kim;Gabe Owens;William Roberts

  • A nonlinear computational model for regional seismic simulation of tall buildings

    Chen Xiong;Xinzheng Lu;Hong Guan;Zhen Xu

  • A coarse-grained parallel approach for seismic damage simulations of urban areas based on refined models and GPU/CPU cooperative computing

    Xinzheng Lu;Bo Han;Muneo Hori;Chen Xiong

  • A virtual reality based fire training simulator with smoke hazard assessment capacity

    Z. Xu;X. Z. Lu;H. Guan;C. Chen

  • Histotripsy-induced cavitation cloud initiation thresholds in tissues of different mechanical properties

    Eli Vlaisavljevich;Adam Maxwell;Matthew Warnez;Eric Johnsen

  • A tissue phantom for visualization and measurement of ultrasound-induced cavitation damage

    Adam D. Maxwell;Tzu Yin Wang;Lingqian Yuan;Alexander P. Duryea

  • High Speed Imaging of Bubble Clouds Generated in Pulsed Ultrasound Cavitational Therapy - Histotripsy

    Zhen Xu;M. Raghavan;T.L. Hall;Ching-Wei Chang

  • Image-guided non-invasive ultrasound liver ablation using histotripsy: Feasibility study in an in vivo porcine model

    Eli Vlaisavljevich;Yohan Kim;Steven Allen;Gabe Owens

Frequent Co-Authors

Charles A. Cain
Charles A. Cain University of Michigan–Ann Arbor
Timothy L. Hall
Timothy L. Hall University of Michigan–Ann Arbor
J. Brian Fowlkes
J. Brian Fowlkes University of Michigan–Ann Arbor
Xiaoning Jiang
Xiaoning Jiang North Carolina State University
Paul A. Dayton
Paul A. Dayton University of North Carolina at Chapel Hill
Oleg A. Sapozhnikov
Oleg A. Sapozhnikov Lomonosov Moscow State University
Vera A. Khokhlova
Vera A. Khokhlova Lomonosov Moscow State University
Michael R. Bailey
Michael R. Bailey University of Washington
Nathan McDannold
Nathan McDannold Brigham and Women's Hospital

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