World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
56
Citations
21195
World Ranking
4435
National Ranking
60

Overview

Yong Shen is affiliated with the Roskamp Institute in the United States. Their research predominantly spans the field of medicine, with a particular focus on surgery and related subfields such as pathology and forensic medicine, biomedical engineering, radiology, nuclear medicine, imaging, and oncology.

The primary topics of Yong Shen's work include scoliosis diagnosis and treatment, spinal fractures and fixation techniques, spine and intervertebral disc pathology, pelvic and acetabular injuries, medical imaging and analysis, cancer immunotherapy and biomarkers, and hemoglobinopathies and related disorders.

Frequent collaborators in their research include Lawrence G. Lenke, Scott L. Zuckerman, Zeeshan M. Sardar, Ronald A. Lehman, and Christopher Lai. This network of coauthors reflects a strong engagement with the spine surgery and broader orthopedic research community.

The scientist has contributed to several publication venues with multiple papers in each, highlighting a concentration in spinal and orthopedic research journals. Notable venues include The Spine Journal, Global Spine Journal, Spine, Journal of Neurosurgery Spine, and Medicine.

Among Yong Shen's recent published papers are:

  • The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes (2020, Science Signaling)
  • A unified model of human hemoglobin switching through single-cell genome editing (2021, Nature Communications)
  • A novel 12-gene prognostic signature in breast cancer based on the tumor microenvironment (2022, Annals of Translational Medicine)
  • Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing (2021, PLoS Genetics)
  • Understanding the role of pelvic obliquity and leg length discrepancy in adult spinal deformity patients with coronal malalignment: unlocking the black box (2022, Journal of Neurosurgery Spine)

Best Publications

  • Inflammation and Alzheimer's disease.

    H Akiyama;S Barger;S Barnum;B Bradt

  • Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer’s Disease

    Lih Fen Lue;Yu Min Kuo;Alex E. Roher;Libuse Brachova

  • Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

  • Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

    Li Bang Yang;Kristina Lindholm;Riqiang Yan;Martin Citron

  • Estrogen synthesis and signaling pathways during aging: from periphery to brain

    Jie Cui;Yong Shen;Rena Li

  • Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients

    Rena Li;Kristina Lindholm;Li-Bang Yang;Xu Yue

  • Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro.

    Lih Fen Lue;Russell Rydel;Elizabeth F. Brigham;Li Bang Yang

  • Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model

    Xu Yue;Melissa Lu;Techie Lancaster;Phillip Cao

  • Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice

    Ping-Ping He;Zhenyu Zhong;Kristina Lindholm;Lilian Berning

  • Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

    Giuseppina Tesco;Young Ho Koh;Eugene L. Kang;Andrew N. Cameron

  • Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment.

    H. Hampel;S. J. Teipel;T. Fuchsberger;N. Andreasen

  • Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

    Kaushik Ghosal;Daniel L. Vogt;Man Liang;Yong Shen

  • MicroRNA-205 regulates the Expression of Parkinson’s disease-related Leucine-rich Repeat Kinase 2 Protein

    Hyun Jin Cho;Guoxiang Liu;Seok Min Jin;Loukia Parisiadou

  • Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain

    Yong Shen;Rena Li;Edith G McGeer;Patrick L McGeer

  • Levels of β-Secretase (BACE1) in Cerebrospinal Fluid as a Predictor of Risk in Mild Cognitive Impairment

    Zhenyu Zhong;Michael Ewers;Stefan Teipel;Katharina Bürger

  • A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

    Huang Chun Tseng;Ying Zhou;Yong Shen;Li Huei Tsai

  • Tumor Necrosis Factor Death Receptor Signaling Cascade Is Required for Amyloid-β Protein-Induced Neuron Death

    Rena Li;Libang Yang;Kristina Lindholm;Yoshihiro Konishi

  • Complement activation by neurofibrillary tangles in Alzheimer's disease.

    Yong Shen;Lih Fen Lue;Li Bang Yang;Alex Roher

  • Target Depletion of Distinct Tumor Necrosis Factor Receptor Subtypes Reveals Hippocampal Neuron Death and Survival through Different Signal Transduction Pathways

    Unknown

  • Estrogen Enhances Uptake of Amyloid β‐Protein by Microglia Derived from the Human Cortex

    Rena Li;Yong Shen;Li Bang Yang;Lih Fen Lue

  • Biological markers of amyloid β-related mechanisms in Alzheimer's disease

    Harald Hampel;Yong Shen;Dominic M. Walsh;Paul Aisen

  • Erratum to Acetylation of tau inhibits its degradation and contributes to tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

Frequent Co-Authors

Michael Ewers
Michael Ewers Ludwig-Maximilians-Universität München
Kaj Blennow
Kaj Blennow University of Gothenburg
Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Stefan J. Teipel
Stefan J. Teipel German Center for Neurodegenerative Diseases
Katharina Buerger
Katharina Buerger Ludwig-Maximilians-Universität München
Seppo Meri
Seppo Meri University of Helsinki
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Vahram Haroutunian
Vahram Haroutunian Icahn School of Medicine at Mount Sinai
Douglas G. Walker
Douglas G. Walker Arizona State University
Huaibin Cai
Huaibin Cai National Institutes of Health

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