W. J. Pledger spends much of his time researching Growth factor, Cell biology, Platelet-derived growth factor receptor, Platelet-derived growth factor and Molecular biology. His Growth factor research includes elements of Cell cycle, Cell culture, Epidermal growth factor and DNA synthesis. His Cell culture research focuses on subjects like Endocrinology, which are linked to Fibroblast growth factor and Cell growth.
His research integrates issues of Integrin, Biochemistry and Neural cell adhesion molecule in his study of Cell biology. The various areas that W. J. Pledger examines in his Platelet-derived growth factor receptor study include Cancer research, Cyclin, Phosphorylation and Ectopic expression. His research in Platelet-derived growth factor intersects with topics in STAT3, Signal transduction, STAT protein and Proto-oncogene tyrosine-protein kinase Src.
W. J. Pledger mainly investigates Cell biology, Growth factor, Platelet-derived growth factor receptor, Molecular biology and Platelet-derived growth factor. His Cell biology research integrates issues from Immunology, Cell cycle, Insulin and Cell growth. His Growth factor research is multidisciplinary, relying on both Cell culture, Epidermal growth factor, Endocrinology and DNA synthesis.
He has researched Cell culture in several fields, including Fibroblast growth factor and Protein biosynthesis. His work is dedicated to discovering how Platelet-derived growth factor receptor, Tyrosine phosphorylation are connected with Tyrosine kinase and other disciplines. His work deals with themes such as Cyclin A, Cyclin D3, Cyclin and Intracellular, which intersect with Molecular biology.
The scientist’s investigation covers issues in Cell biology, Cyclin-dependent kinase, Cyclin, Cyclin A and Molecular biology. He does research in Cell biology, focusing on Fibronectin specifically. His Cyclin study necessitates a more in-depth grasp of Cell cycle.
His work carried out in the field of Cyclin A brings together such families of science as Cyclin-dependent kinase complex, Cyclin D, Cyclin A2 and Cyclin B. As part of the same scientific family, he usually focuses on Molecular biology, concentrating on Cyclin D3 and intersecting with Psychological repression and Cyclin D2. His Cancer research research focuses on STAT protein and how it connects with Platelet-derived growth factor receptor.
His primary scientific interests are in Cell biology, Cyclin E, Cyclin B, Cyclin A and Cyclin-dependent kinase complex. His Cell biology research is multidisciplinary, incorporating perspectives in Integrin and Cell adhesion, Neural cell adhesion molecule. His work carried out in the field of Cyclin B brings together such families of science as Cyclin-dependent kinase, Cyclin A2 and Cyclin D.
His Cyclin D1 study which covers Cancer research that intersects with Proto-oncogene tyrosine-protein kinase Src, Ectopic expression, Signal transduction and STAT3. The various areas that he examines in his Platelet-derived growth factor study include Cyclin D2 and Cyclin. His Platelet-derived growth factor receptor research entails a greater understanding of Growth factor.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Dual control of cell growth by somatomedins and platelet-derived growth factor
C D Stiles;G T Capone;C D Scher;H N Antoniades.
Proceedings of the National Academy of Sciences of the United States of America (1979)
Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process
W. J. Pledger;C. D. Stiles;H. N. Antoniades;C. D. Scher.
Proceedings of the National Academy of Sciences of the United States of America (1977)
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
Tammy Bowman;Martin A. Broome;Dominic Sinibaldi;Walker Wharton.
Proceedings of the National Academy of Sciences of the United States of America (2001)
An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis
W. J. Pledger;C. D. Stiles;H. N. Antoniades;C. D. Scher.
Proceedings of the National Academy of Sciences of the United States of America (1978)
Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin
Han C. Dan;Mei Sun;Lin Yang;Richard I. Feldman.
Journal of Biological Chemistry (2002)
Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).
L A Hazlehurst;J S Damiano;I Buyuksal;W J Pledger.
Neurotrophic protein S100 beta stimulates glial cell proliferation.
R H Selinfreund;S W Barger;W J Pledger;L J Van Eldik.
Proceedings of the National Academy of Sciences of the United States of America (1991)
Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells.
Edward B. Leof;Walker Wharton;Judson J. Van Wyk;W.J. Pledger.
Experimental Cell Research (1982)
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling.
Dominic Sinibaldi;Walker Wharton;James Turkson;Tammy Bowman.
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.
M. I. Wahl;N. E. Olashaw;S. Nishibe;Sue Goo Rhee.
Molecular and Cellular Biology (1989)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: