World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
11653
World Ranking
17501
National Ranking
7188

Overview

W. J. Pledger is affiliated with the University of South Florida in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on Oncology, Cancer Research, and Pulmonary and Respiratory Medicine. Their work involves molecular biology techniques alongside pathology and forensic medicine.

The scientist's recent publications cover a range of topics related to cancer biology and treatment, emphasizing colorectal cancer and molecular pathways associated with tumor behavior and drug resistance. Notable recent papers include:

  • APC and TP53 Mutations Predict Cetuximab Sensitivity across Consensus Molecular Subtypes, 2021, published in Cancers
  • An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy, 2022, BMC Cancer
  • The deubiquitylase USP7 is a novel cyclin F-interacting protein and regulates cyclin F protein stability, 2022, Aging
  • Identifying distinct prognostic and predictive contributions of tumor epithelium versus tumor microenvironment in colorectal cancer, 2025, BMC Cancer
  • Abstract 1083: A novel role of SRC in mediating bypass resistance to MEK inhibition in colorectal cancer stem cells, 2021, Cancer Research

Their research topics include colorectal cancer treatments and studies, cancer genomics and diagnostics, lung cancer treatments and mutations, genetic factors in colorectal cancer, melanoma and MAPK pathways, ubiquitin and proteasome pathways, and cancer-related molecular pathways.

W. J. Pledger collaborates frequently with other researchers. Key coauthors include Mingli Yang, Timothy J. Yeatman, Lance Pflieger, Michael Nebozhyn, and Michael J. Schell, each contributing to multiple joint publications.

The scientist has published in several academic venues, with a significant number of papers appearing in Cancer Research and Journal of Clinical Oncology. Other frequent publication venues include BMC Cancer, Cancers, and Aging.

Best Publications

  • Dual control of cell growth by somatomedins and platelet-derived growth factor

    C D Stiles;G T Capone;C D Scher;H N Antoniades

  • Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

    W. J. Pledger;C. D. Stiles;H. N. Antoniades;C. D. Scher

  • Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

    Tammy Bowman;Martin A. Broome;Dominic Sinibaldi;Walker Wharton

  • An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis

    W. J. Pledger;C. D. Stiles;H. N. Antoniades;C. D. Scher

  • Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

    Han C. Dan;Mei Sun;Lin Yang;Richard I. Feldman

  • Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).

    L A Hazlehurst;J S Damiano;I Buyuksal;W J Pledger

  • Neurotrophic protein S100 beta stimulates glial cell proliferation.

    R H Selinfreund;S W Barger;W J Pledger;L J Van Eldik

  • Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling.

    Dominic Sinibaldi;Walker Wharton;James Turkson;Tammy Bowman

  • Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells.

    Edward B. Leof;Walker Wharton;Judson J. Van Wyk;W.J. Pledger

  • Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

    M. I. Wahl;N. E. Olashaw;S. Nishibe;Sue Goo Rhee

  • Regulation of the cell cycle machinery by oncogenic ras.

    J. T. Winston;S. R. Coats;Yi-Zhe Wang;W. J. Pledger

  • Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/c-3T3 cells.

    B Herman;W J Pledger

  • Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells.

    D Agrawal;P Hauser;F McPherson;F Dong

  • Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C

    W E Russell;J J Van Wyk;W J Pledger

  • A model of cell cycle control: sequential events regulated by growth factors.

    Edward J. O'Keefe;W.J. Pledger

  • Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity.

    Yi-Zhe Wang;Walker Wharton;Roy Garcia;Alan Kraker

  • Platelet-derived growth factor-modulated proteins: constitutive synthesis by a transformed cell line.

    W J Pledger;C A Hart;K L Locatell;C D Scher

  • Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: analysis using platelet-derived growth factor and platelet-poor plasma.

    C. D. Stiles;R. R. Isberg;W. J. Pledger;H. N. Antoniades

  • Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model.

    Jalila Adnane;Rosalind J Jackson;Santo V Nicosia;Alan B Cantor

  • Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms

    J T Winston;W J Pledger

Frequent Co-Authors

Edward J. O'Keefe
Edward J. O'Keefe University of North Carolina at Chapel Hill
Charles D. Stiles
Charles D. Stiles Harvard University
Said M. Sebti
Said M. Sebti Virginia Commonwealth University
Domenico Coppola
Domenico Coppola Moffitt Cancer Center
Judson J. Van Wyk
Judson J. Van Wyk University of North Carolina at Chapel Hill
Richard Jove
Richard Jove Nova Southeastern University
Brian Herman
Brian Herman The University of Texas Health Science Center at San Antonio
Sara A. Courtneidge
Sara A. Courtneidge Oregon Health & Science University
Ralph R. Isberg
Ralph R. Isberg Tufts University
Dicky J. J. Halley
Dicky J. J. Halley Erasmus University Rotterdam

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