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Biology and Biochemistry

D-Index
55
Citations
8870
World Ranking
15247
National Ranking
6370

Overview

Tze-chen Hsieh is affiliated with New York Medical College in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine with specific contributions to Molecular Biology, Geriatrics and Gerontology, Pulmonary and Respiratory Medicine, Surgery, and Oncology.

The scientist's work focuses on several main topics, including:

  • Sirtuins and Resveratrol in Medicine
  • Prostate Cancer Treatment and Research
  • Xenotransplantation and Immune Response
  • Cancer Cells and Metastasis
  • FOXO Transcription Factor Regulation
  • Cancer Genomics and Diagnostics
  • CRISPR and Genetic Engineering

Selected recent papers authored or coauthored by Tze-chen Hsieh include:

  • "Resveratrol Suppresses Prostate Cancer Epithelial Cell Scatter/Invasion by Targeting Inhibition of Hepatocyte Growth Factor (HGF) Secretion by Prostate Stromal Cells and Upregulation of E-cadherin by Prostate Cancer Epithelial Cells," 2020, International Journal of Molecular Sciences
  • "Trailblazing Perspectives on Targeting Breast Cancer Stem Cells," 2021, Pharmacology & Therapeutics
  • "Elucidating the Inhibitory Effect of Resveratrol and Its Structural Analogs on Selected Nucleotide-Related Enzymes," 2020, Biomolecules

Their published work is frequently found in venues such as:

  • International Journal of Molecular Sciences
  • Pharmacology & Therapeutics
  • Biomolecules

Collaboration plays a role in their research, with frequent coauthors including:

  • Joseph Wu
  • Juntao Li
  • Dan Qi
  • Jason H. Huang
  • Erxi Wu

Tze-chen Hsieh's interdisciplinary approach involves combining molecular biology techniques with clinical insights to address complex biological mechanisms underlying cancer, immune response, and aging-related processes. Their research on resveratrol, a compound with potential therapeutic roles, ties together biochemical pathways and translational medicine.

Best Publications

  • DIFFERENTIAL EFFECTS ON GROWTH, CELL CYCLE ARREST, AND INDUCTION OF APOPTOSIS BY RESVERATROL IN HUMAN PROSTATE CANCER CELL LINES

    Tze-chen Hsieh;Joseph M. Wu

  • Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review)

    Joseph M. Wu;Zhi-Rong Wang;Tze-Chen Hsieh;Jed L. Bruder

  • Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2.

    Tze-chen Hsieh;Gloria Juan;Zbigniew Darzynkiewicz;Joseph M. Wu

  • Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells.

    Yue Fu;Tze-chen Hsieh;Junqiao Guo;Jan Kunicki

  • Crystal Structure of Quinone Reductase 2 in Complex with Resveratrol

    Leonid Buryanovskyy;Yue Fu;Molly Boyd;Yuliang Ma

  • Simultaneous Human Granulocytic Ehrlichiosis and Lyme Borreliosis

    Robert B. Nadelman;Harold W. Horowitz;Tze-chen Hsieh;Joseph M. Wu

  • Differential control of growth, cell cycle progression, and expression of NF-κB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens

    Tze Chen Hsieh;E. Kithsiri Wijeratne;Jing Yu Liang;A. Leslie Gunatilaka

  • Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels

    Zhirong Wang;Jiangang Zou;Kejiang Cao;Tze-Chen Hsieh

  • Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials.

    T C Hsieh;P Burfeind;K Laud;J M Backer

  • Resveratrol: a cardioprotective substance.

    Joseph M. Wu;Tze-chen Hsieh

  • Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy.

    G. Zhang;Y. Wang;Y. Zhang;X. Wan

  • Mechanism of fenretinide (4-HPR)-induced cell death.

    J. M. Wu;A. M. DiPietrantonio;T.-C. Hsieh

  • Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry.

    Piotr Smolewski;Elzbieta Bedner;Litong Du;Tze-Chen Hsieh

  • Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines.

    S. Chen;Q. Ruan;E. Bedner;A. Deptala

  • Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

    Shuang Zhou;Fengfei Wang;Eric T. Wong;Ekokobe Fonkem

  • Activation of Caspase 3 in HL-60 Cells Exposed to Hydrogen Peroxide

    Anna M. DiPietrantonio;Tze-chen Hsieh;Joseph M. Wu

  • Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2.

    Tze-chen Hsieh;Xiaohua Lu;Zhirong Wang;Joseph M Wu

  • Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and γ-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells

    Tze-Chen Hsieh;Joseph M Wu

  • Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53.

    Tze-chen Hsieh;Zhirong Wang;Carl V. Hamby;Joseph M. Wu

  • Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism.

    Hsieh Tc;Wu Jm

Frequent Co-Authors

Joseph M. Wu
Joseph M. Wu New York Medical College
Zbigniew Darzynkiewicz
Zbigniew Darzynkiewicz New York Medical College
Erxi Wu
Erxi Wu Scott & White Memorial Hospital
Gary P. Wormser
Gary P. Wormser New York Medical College
Frank Traganos
Frank Traganos New York Medical College
Min Wu
Min Wu University of North Dakota
Ira Schwartz
Ira Schwartz New York Medical College
J. Stephen Dumler
J. Stephen Dumler Uniformed Services University of the Health Sciences
Leroy F. Liu
Leroy F. Liu Taipei Medical University
Robert B. Nadelman
Robert B. Nadelman New York Medical College

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