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Biology and Biochemistry

D-Index
55
Citations
16032
World Ranking
14809
National Ranking
1167

Overview

Stephen M. Keyse is affiliated with the University of Dundee in the United Kingdom. Their research primarily focuses on medicine and neuroscience, with specific subfields including oncology, surgery, epidemiology, pulmonary and respiratory medicine, and molecular biology.

The scientist's work spans several main research topics, including pancreatic and hepatic oncology research, pancreatitis pathology and treatment, neuroendocrine tumor research advances, pulmonary hypertension research and treatments, protein tyrosine phosphatases, renin-angiotensin system studies, and nerve injury and regeneration.

Notable recent publications by Stephen M. Keyse include:

  • Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6, 2022, Oncogene
  • DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy, 2021, American Journal of Physiology-Heart and Circulatory Physiology
  • Repair oligodendrocytes demyelinating and disintegrating damaged axons after injury, 2023, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors in Keyse's work include:

  • Andrew M. Kidger
  • Mark K. Saville
  • Linda Rushworth
  • Jane Davidson
  • Julia Stellzig

Stephen M. Keyse has published across several scientific venues, including:

  • Oncogene
  • American Journal of Physiology-Heart and Circulatory Physiology
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

    Stephen M. Keyse;Rex M. Tyrrell

  • Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

    Stephen M Keyse

  • Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases

    D M Owens;S M Keyse

  • Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase.

    Stephen M. Keyse;Elizabeth A. Emslie

  • Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry

    Anne Brunet;Danièle Roux;Philippe Lenormand;Stephen Dowd

  • Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling.

    Christopher J. Caunt;Stephen M. Keyse

  • Dual-specificity MAP kinase phosphatases (MKPs) and cancer.

    Stephen M. Keyse

  • Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

    Linda A. Groom;Alan A. Sneddon;Dario R. Alessi;Stephen Dowd

  • Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

    Dario R. Alessi;Nestor Gomez;Greg Moorhead;Tom Lewis

  • The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.

    Alessi Dr;Smythe C;Keyse Sm

  • Diverse physiological functions for dual-specificity MAP kinase phosphatases.

    Robin J. Dickinson;Stephen M. Keyse

  • New trends in photobiology. The interaction of UVA radiation with cultured cells.

    R.M. Tyrrell;S.M. Keyse

  • An emerging family of dual specificity MAP kinase phosphatases

    Stephen M. Keyse

  • Distinct Binding Determinants for ERK2/p38α and JNK MAP Kinases Mediate Catalytic Activation and Substrate Selectivity of MAP Kinase Phosphatase-1

    David N. Slack;Ole-Morten Seternes;Mads Gabrielsen;Stephen M. Keyse

  • Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts.

    Stephen M. Keyse;Rex M. Tyrrell

  • Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.

    S M Keyse;L A Applegate;Y Tromvoukis;R M Tyrrell

  • Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

    Angela Glading;Florian Überall;Stephen M. Keyse;Douglas A. Lauffenburger

  • Transcriptional Induction of MKP-1 in Response to Stress Is Associated with Histone H3 Phosphorylation-Acetylation

    Ji Li;Myriam Gorospe;Dorothy Hutter;Janice Barnes

  • Specific Inactivation and Nuclear Anchoring of Extracellular Signal-Regulated Kinase 2 by the Inducible Dual-Specificity Protein Phosphatase DUSP5

    Margret Mandl;David N. Slack;Stephen M. Keyse

  • The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

    Andrew M. Kidger;Stephen M. Keyse

Frequent Co-Authors

Rex M. Tyrrell
Rex M. Tyrrell University of Bath
Cheryll Tickle
Cheryll Tickle University of Bath
Dario R. Alessi
Dario R. Alessi University of Dundee
Michael J. R. Stark
Michael J. R. Stark University of Dundee
Andrew C.B. Cato
Andrew C.B. Cato Karlsruhe Institute of Technology
Marcel Dorée
Marcel Dorée Centre national de la recherche scientifique, CNRS
Albena T. Dinkova-Kostova
Albena T. Dinkova-Kostova University of Dundee
Owen J. Sansom
Owen J. Sansom University of Glasgow
Ugo Moens
Ugo Moens University of Tromsø - The Arctic University of Norway
Simon J. Cook
Simon J. Cook Babraham Institute

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