Stephen M. Keyse mostly deals with Biochemistry, Cell biology, Mitogen-activated protein kinase, MAPK/ERK pathway and Molecular biology. His study in Protein kinase A and MAP kinase phosphatase are all subfields of Cell biology. The concepts of his MAP kinase phosphatase study are interwoven with issues in MAPK7, MAPKAPK2, MAP kinase kinase kinase, MAP2K7 and ASK1.
As part of the same scientific family, Stephen M. Keyse usually focuses on Mitogen-activated protein kinase, concentrating on Dual-specificity phosphatase and intersecting with Signalling, Crosstalk and Tyrosine. In his study, which falls under the umbrella issue of MAPK/ERK pathway, p38 mitogen-activated protein kinases is strongly linked to DUSP6. His study in Molecular biology is interdisciplinary in nature, drawing from both Oxygenase, Heme oxygenase and Phosphatase.
Stephen M. Keyse mainly focuses on Cell biology, Molecular biology, Biochemistry, MAPK/ERK pathway and Mitogen-activated protein kinase. His work is dedicated to discovering how Molecular biology, Nucleotide excision repair are connected with Aphidicolin and Human skin and other disciplines. His work on Hydrogen peroxide, Heat shock protein, Oxidative stress and Saccharomyces cerevisiae as part of general Biochemistry research is often related to Nuclear export signal, thus linking different fields of science.
His work in MAPK/ERK pathway addresses issues such as Phosphatase, which are connected to fields such as Protein tyrosine phosphatase. His study looks at the relationship between Mitogen-activated protein kinase and fields such as Signalling, as well as how they intersect with chemical problems. His MAP kinase kinase kinase study combines topics in areas such as c-Raf, ASK1, Mitogen-activated protein kinase kinase and MAP2K7.
His primary areas of study are Cell biology, MAPK/ERK pathway, Dual-specificity phosphatase, Mitogen-activated protein kinase and Kinase. His Cell biology and DUSP6, Mitogen-activated protein kinase kinase, MAP kinase kinase kinase and Phosphatase investigations all form part of his Cell biology research activities. The Mitogen-activated protein kinase kinase study combines topics in areas such as Cyclin-dependent kinase 2 and MAP2K7.
His MAPK/ERK pathway research is multidisciplinary, incorporating perspectives in Molecular biology and Protein kinase A. His research investigates the connection with Mitogen-activated protein kinase and areas like Signalling which intersect with concerns in Gene isoform, Crosstalk and MAP kinase phosphatase. His work on Receptor tyrosine kinase as part of general Kinase study is frequently linked to Oncogene, bridging the gap between disciplines.
His scientific interests lie mostly in Cell biology, MAPK/ERK pathway, Dual-specificity phosphatase, Mitogen-activated protein kinase and DUSP6. Signal transduction is the focus of his Cell biology research. His MAPK/ERK pathway research incorporates elements of Caenorhabditis elegans and DNA damage.
The study incorporates disciplines such as Anti-apoptotic Ras signalling cascade, DMBA, Immunology and Ectopic expression in addition to Dual-specificity phosphatase. His Mitogen-activated protein kinase study is concerned with the field of Kinase as a whole. His biological study spans a wide range of topics, including Protein kinase A, Carcinogenesis, MAP kinase phosphatase, Signalling and Gene isoform.
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Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.
Stephen M. Keyse;Rex M. Tyrrell.
Proceedings of the National Academy of Sciences of the United States of America (1989)
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.
Stephen M Keyse.
Current Opinion in Cell Biology (2000)
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
D M Owens;S M Keyse.
Oncogene (2007)
Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase.
Stephen M. Keyse;Elizabeth A. Emslie.
Nature (1992)
Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry
Anne Brunet;Danièle Roux;Philippe Lenormand;Stephen Dowd.
The EMBO Journal (1999)
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
Stephen M. Keyse.
Cancer and Metastasis Reviews (2008)
Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.
Linda A. Groom;Alan A. Sneddon;Dario R. Alessi;Stephen Dowd.
The EMBO Journal (1996)
Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling.
Christopher J. Caunt;Stephen M. Keyse.
FEBS Journal (2013)
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines
Dario R. Alessi;Nestor Gomez;Greg Moorhead;Tom Lewis.
Current Biology (1995)
The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.
Alessi Dr;Smythe C;Keyse Sm.
Oncogene (1993)
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