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Neuroscience

D-Index
39
Citations
7620
World Ranking
8267
National Ranking
3546

Overview

Sheryl S. Smith is affiliated with SUNY Downstate Medical Center in the United States and contributes to the field of Neuroscience, with a focus on Cellular and Molecular Neuroscience, Behavioral Neuroscience, Social Psychology, Cognitive Neuroscience, and Physiology. Their research intersects several main topics including Stress Responses and Cortisol, Neuroscience and Neuropharmacology Research, Neuroendocrine Regulation and Behavior, Memory and Neural Mechanisms, Pain Mechanisms and Treatments, Ion Channel Regulation and Function, and Genetic Syndromes and Imprinting.

Smith has authored multiple peer-reviewed papers, with research published primarily in Brain Research, SSRN Electronic Journal, Scientific Reports, Frontiers in Cellular Neuroscience, and Frontiers in Neuroscience. Noteworthy publications include:

  • "Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABAA receptors increases anxiety response in adulthood" (2021) in Scientific Reports
  • "Increased Dendritic Branching of and Reduced δ-GABAA Receptor Expression on Parvalbumin-Positive Interneurons Increase Inhibitory Currents and Reduce Synaptic Plasticity at Puberty in Female Mouse CA1 Hippocampus" (2020) in Frontiers in Cellular Neuroscience
  • "Manipulation of α4βδ GABAA receptors alters synaptic pruning in layer 3 prelimbic prefrontal cortex and impairs temporal order recognition: Implications for schizophrenia and autism" (2024) in Brain Research
  • "Sex differences in motor learning flexibility are accompanied by sex differences in mushroom spine pruning of the mouse primary motor cortex during adolescence" (2024) in Frontiers in Neuroscience
  • "Evidence of pharmacodynamic tolerance during repeated daily gaboxadol exposure in individuals with Angelman syndrome (1358)" (2020) in Neurology

Smith frequently collaborates with a group of coauthors who have appeared in multiple published works. These include Lindsay Kenney, Matthew R. Evrard, Hui Shen, Safae Benanni, and Quiana Jones.

Their research explores mechanisms related to inhibitory neurotransmission, synaptic pruning during adolescence, and neurodevelopmental topics that overlap conditions such as schizophrenia and autism. This includes investigating the role of specific GABAA receptor subtypes in neural circuit development and behavioral outcomes.

Primary research fields and subfields include:

  • Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Social Psychology
  • Cognitive Neuroscience
  • Physiology

Main topics of Smith's work are:

  • Stress Responses and Cortisol
  • Neuroscience and Neuropharmacology Research
  • Neuroendocrine regulation and behavior
  • Memory and Neural Mechanisms
  • Pain Mechanisms and Treatments
  • Ion channel regulation and function
  • Genetic Syndromes and Imprinting

Best Publications

  • GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid

    Unknown

  • Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety.

    Sheryl S. Smith;Qi H. Gong;Xinshe Li;Maria H. Moran

  • Hormonally regulated α4β2δ GABAA receptors are a target for alcohol

    Inger Sundstrom-Poromaa;Deborah H. Smith;Qi Hua Gong;Thomas N. Sabado

  • Reversal of neurosteroid effects at α4β2δ GABAA receptors triggers anxiety at puberty

    Hui Shen;Qi Hua Gong;Chiye Aoki;Maoli Yuan

  • Neurosteroid regulation of GABAA receptors: Focus on the α4 and δ subunits

    Sheryl S. Smith;Hui Shen;Qi Hua Gong;Xiangping Zhou

  • Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action

    Sheryl S. Smith;Barry D. Waterhouse;John K. Chapin;Donald J. Woodward

  • Short-term exposure to a neuroactive steroid increases α4 GABAA receptor subunit levels in association with increased anxiety in the female rat

    M Gulinello;Q.H Gong;X Li;S.S Smith

  • Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect.

    Sheryl S. Smith

  • Female sex steroid hormones: from receptors to networks to performance—actions on the sensorimotor system

    Sheryl S. Smith

  • Short-term steroid treatment increases δ GABAA receptor subunit expression in rat CA1 hippocampus: Pharmacological and behavioral effects

    Hui Shen;Qi Hua Gong;Maoli Yuan;Sheryl S. Smith

  • Progesterone withdrawal decreases latency to and increases duration of electrified prod burial : a possible rat model of PMS anxiety

    Mary Ann Gallo;Sheryl S. Smith

  • A Critical Role for α4βδ GABAA Receptors in Shaping Learning Deficits at Puberty in Mice

    Hui Shen;Nicole Sabaliauskas;Ang Sherpa;Ang Sherpa;André A. Fenton

  • Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells.

    S.S. Smith

  • Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5β-THP: a possible model of premenstrual dysphoric disorder

    Sheryl S. Smith;Yevgeniy Ruderman;Cheryl Frye;Gregg Homanics

  • GABA receptors, progesterone and premenstrual dysphoric disorder

    I. Sundström Poromaa;S. Smith;M. Gulinello

  • Sex steroid effects on extrahypothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum

    Sheryl S. Smith;Barry D. Waterhouse;Donald J. Woodward

  • Locally applied estrogens potentiate glutamate-evoked excitation of cerebellar Purkinje cells.

    Sheryl S. Smith;Barry D. Waterhouse;Donald J. Woodward

  • Sex steroid effects on extrahypothalamic CNS. II. Progesterone, alone and in combination with estrogen, modulates cerebellar responses to amino acid neurotransmitters

    Sheryl S. Smith;Barry D. Waterhouse;Donald J. Woodward

  • Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum.

    Sheryl S. Smith;B.D. Waterhouse;D.J. Woodward

  • Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.

    Maria Gulinello;Sheryl S. Smith

  • Gabaa Receptor alpha 4 Subunit Suppression Prevents Withdrawal Properties of an Endogenous Steroid

    Sheryl Smith;Qi Hua Gong;Fu-chun Hsu;Ronald S. Markowitz

Frequent Co-Authors

Chiye Aoki
Chiye Aoki New York University
Donald J. Woodward
Donald J. Woodward University of North Carolina School of Medicine
Barry D. Waterhouse
Barry D. Waterhouse Rowan University
Cheryl A. Frye
Cheryl A. Frye University at Albany, State University of New York
John K. Chapin
John K. Chapin State University of New York
Gregg E. Homanics
Gregg E. Homanics University of Pittsburgh
Martin Wiedmann
Martin Wiedmann Cornell University
André A. Fenton
André A. Fenton New York University
Catherine S. Woolley
Catherine S. Woolley Northwestern University

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