Sean F. Brady

Overview

Best Publications

• Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products

  Jo Handelsman;Michelle R. Rondon;Sean F. Brady;Jon Clardy

  2800
  Citations

• Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms.

  Michelle R. Rondon;Paul R. August;Alan D. Bettermann;Sean F. Brady

  1736
  Citations

• Minimum Information about a Biosynthetic Gene cluster.

  Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  925
  Citations

• Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA.

  Doreen E. Gillespie;Sean F. Brady;Alan D. Bettermann;Nicholas P. Cianciotto

  689
  Citations

• Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.

  Bradley M. Hover;Seong Hwan Kim;Micah Katz;Zachary Charlop-Powers

  435
  Citations

• Commensal bacteria make GPCR ligands that mimic human signalling molecules

  Louis J. Cohen;Louis J. Cohen;Daria Esterhazy;Seong-Hwan Kim;Christophe Lemetre

  430
  Citations

• Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules.

  Sean F Brady

  272
  Citations

• The cytosporones, new octaketide antibiotics isolated from an endophytic fungus.

  Sean F. Brady;Melissa M. Wagenaar;Maya P. Singh;Jeff E. Janso

  246
  Citations

• Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria

  Jeffrey W. Craig;Fang-Yuan Chang;Jeffrey H. Kim;Steven C. Obiajulu

  241
  Citations

• Discovery of MRSA active antibiotics using primary sequence from the human microbiome

  John Chu;Xavier Vila-Farres;Daigo Inoyama;Melinda Ternei

  216
  Citations

• New Natural Product Families from an Environmental DNA (eDNA) Gene Cluster

  Sean F Brady;Carol J Chao;Jon Clardy

  206
  Citations

• The Guanacastepenes: A Highly Diverse Family of Secondary Metabolites Produced by an Endophytic Fungus

  Sean F. Brady;Shana M. Bondi;Jon Clardy

  206
  Citations

• Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

  Aleksandr Milshteyn;Jessica S. Schneider;Sean F. Brady;Sean F. Brady

  205
  Citations

• Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.

  Louis J. Cohen;Hahk-Soo Kang;John Chu;Yun-Han Huang

  177
  Citations

• Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites

  Zhiyang Feng;Dimitris Kallifidas;Sean F. Brady

  168
  Citations

• Metagenomic approaches to natural products from free-living and symbiotic organisms.

  Sean F. Brady;Luke Simmons;Jeffrey H. Kim;Eric W. Schmidt

  160
  Citations

• Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules.

  Jacob J Banik;Sean F Brady

  157
  Citations

• Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary

  Jacob J. Banik;Sean F. Brady

  152
  Citations

• Global biogeographic sampling of bacterial secondary metabolism.

  Zachary Charlop-Powers;Jeremy G Owen;Boojala Vijay B Reddy;Melinda A Ternei

  151
  Citations

• Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens

  John B. Biggins;Melinda A. Ternei;Sean F. Brady

  150
  Citations