World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
67
Citations
13857
World Ranking
7035
National Ranking
2091

Research.com Recognitions

  • 2011 - Fellow of the American Chemical Society
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1992 - Fellow of Alfred P. Sloan Foundation

Overview

Scott D. Rychnovsky is affiliated with the University of California, Irvine in the United States. Their research spans primarily across materials science and chemistry, focusing on various subfields including materials chemistry, spectroscopy, organic chemistry, molecular biology, and cell biology.

The main topics addressed in their work cover crystallization and solubility studies, X-ray diffraction in crystallography, advanced proteomics techniques and applications, ubiquitin and proteasome pathways, mass spectrometry techniques and applications, synthetic organic chemistry methods, and asymmetric synthesis and catalysis.

They have published extensively in several venues, with the most frequent publication outlets including The Cambridge Structural Database, Organic Letters, Analytical Chemistry, Proceedings of the National Academy of Sciences, and The Journal of Organic Chemistry.

Scott D. Rychnovsky has authored numerous papers, with recent notable publications such as:

  • Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry, 2021, Proceedings of the National Academy of Sciences
  • Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling, 2020, Proceedings of the National Academy of Sciences
  • Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers, 2021, Molecular & Cellular Proteomics
  • Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis, 2022, Analytical Chemistry
  • Discovery of compounds that reactivate p53 mutants in vitro and in vivo, 2022, Cell chemical biology

The scientist has collaborated frequently with several coauthors, including Charles Dooley, Paul R. Carlson, Alexander S. Burns, Joseph W. Ziller, and Clinton Yu.

Scott D. Rychnovsky has received recognition in the form of multiple fellowships throughout their career:

  • Fellow of the American Chemical Society (2011)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2007)
  • Fellow of Alfred P. Sloan Foundation (1992)

Best Publications

  • Stereochemistry of alternating polyol chains: 13C NMR analysis of 1,3-diol acetonides

    Scott D. Rychnovsky;Donald J. Skalitzky

  • Analysis of two carbon-13 NMR correlations for determining the stereochemistry of 1,3-diol acetonides

    Scott D. Rychnovsky;Bruce Rogers;Guang Yang

  • Oxo Polyene Macrolide Antibiotics

    Scott D. Rychnovsky

  • Development of a Novel Cross-linking Strategy for Fast and Accurate Identification of Cross-linked Peptides of Protein Complexes

    Athit Kao;Chi-li Chiu;Danielle Vellucci;Yingying Yang

  • Configurational Assignment of Polyene Macrolide Antibiotics Using the [13C]Acetonide Analysis

    Scott D. Rychnovsky;and Bruce N. Rogers;Timothy I. Richardson

  • Free-radical cyclization of bromo acetals. Use in the construction of bicyclic acetals and lactones

    Gilbert Stork;Robert Mook;Scott A. Biller;Scott D. Rychnovsky

  • Stereocontrolled synthesis of cis-2,5-disubstituted tetrahydrofurans and cis- and trans-linalyl oxides

    Scott D. Rychnovsky;Paul A. Bartlett

  • Predicting NMR spectra by computational methods: structure revision of hexacyclinol.

    Scott D. Rychnovsky

  • Mukaiyama aldol-Prins cyclization cascade reaction: a formal total synthesis of leucascandrolide A.

    David J. Kopecky;Scott D. Rychnovsky

  • Synthesis of (-)-centrolobine by Prins cyclizations that avoid racemization.

    Shinji Marumoto;James J Jaber;Justin P Vitale;Scott D Rychnovsky

  • Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

    Benjamin R. Myers;Navdar Sever;Yong Chun Chong;James Kim

  • General Synthesis of alpha-Acetoxy Ethers from Esters by DIBALH Reduction and Acetylation.

    Vilas H. Dahanukar;Scott D. Rychnovsky

  • Improved procedure for the reductive acetylation of acyclic esters and a new synthesis of ethers.

    David J. Kopecky;Scott D. Rychnovsky

  • A New in Vivo Cross-linking Mass Spectrometry Platform to Define Protein–Protein Interactions in Living Cells

    Robyn M. Kaake;Xiaorong Wang;Anthony Burke;Clinton Yu

  • Stereoselectivity and Regioselectivity in the Segment-Coupling Prins Cyclization

    James J. Jaber;Kazuhiko Mitsui;Scott D. Rychnovsky

  • Dual roles for cholesterol in mammalian cells

    Fang Xu;Scott D. Rychnovsky;Jitendra D. Belani;Helen H. Hobbs

  • Synthesis of the C22-C26 tetrahydropyran segment of phorboxazole by a stereoselective prins cyclization

    Scott D. Rychnovsky;Christian R. Thomas

  • Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

    Andrew Wheat;Clinton Yu;Xiaorong Wang;Anthony M Burke

  • TEMPO-Catalyzed Oxidations of Alcohols Using m-CPBA: The Role of Halide Ions.

    Scott D. Rychnovsky;Rajappa Vaidyanathan

  • Concise total synthesis of (+)-(9S)-dihydroerythronolide A

    Gilbert Stork;Scott D. Rychnovsky

  • Formal Synthesis of (−)-Kendomycin Featuring a Prins-Cyclization to Construct the Macrocycle

    Kevin B. Bahnck;Scott D. Rychnovsky

Frequent Co-Authors

Lan Huang
Lan Huang University of California, Irvine
Gilbert Stork
Gilbert Stork Columbia University
Ramesh Jasti
Ramesh Jasti University of Oregon
Andrej Sali
Andrej Sali University of California, San Francisco
David A. Evans
David A. Evans Harvard University
Kenneth J. Shea
Kenneth J. Shea University of California, Irvine
Ning Zheng
Ning Zheng University of Washington
Joseph W. Ziller
Joseph W. Ziller University of California, Irvine
William Fenical
William Fenical University of California, San Diego

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