World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
58
Citations
8836
World Ranking
3570
National Ranking
5

Overview

Rui Appelberg was affiliated with the University of Porto in Portugal and contributed to research primarily in the fields of immunology and microbiology. Their scholarly work focused on understanding immune mechanisms and interactions, with specific attention to T-cell and B-cell immunology, immune response and inflammation, and immune cell function and interaction.

The scientist's research also explored glycosylation and glycoproteins, immunodeficiency and autoimmune disorders, and issues related to Mycobacterium research and diagnosis. The overlap of these topics is reflected in their body of work, which addressed complex aspects of immune system function and pathogen interactions.

Rui Appelberg's publication record included papers in venues such as Mucosal Immunology, Frontiers in Immunology, and bioRxiv (Cold Spring Harbor Laboratory). Their recent papers include:

  • Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils, 2020, Mucosal Immunology
  • IFNγ and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy, 2021, Frontiers in Immunology
  • IFNγ and iNOS-mediated alterations in the bone marrow and thymus and its impact on Mycobacterium avium-induced thymic atrophy, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Their research collaborations were frequent and involved multiple coauthors, including Palmira Barreira-Silva, Rita Melo-Miranda, Cláudia Nóbrega, Susana Roque, and Cláudia Serre-Miranda. These collaborative efforts spanned similar thematic areas in immunology and infection biology.

Appelberg's work consistently focused on mechanisms of immune cell regulation and the effects of infectious agents on immune tissue, especially in relation to tuberculosis and Mycobacterium avium infections. The studies on glycosyltransferase Gcnt1 and IFNγ/iNOS-mediated changes in immune organs addressed pathways that modulate susceptibility to infection and immune system impairment.

Best Publications

  • Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis

    Lise Brandt;Joana Feino Cunha;Anja Weinreich Olsen;Ben Chilima;Ben Chilima

  • Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice.

    Jorge Pedrosa;Bernadette M. Saunders;Rui Appelberg;Ian M. Orme

  • Adjuvant modulation of immune responses to tuberculosis subunit vaccines.

    E B Lindblad;M J Elhay;R Silva;R Appelberg

  • The Effect of the Host's Iron Status on Tuberculosis

    Johan R. Boelaert;Stefaan J. Vandecasteele;Rui Appelberg;Victor R. Gordeuk

  • Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection.

    R Appelberg;A G Castro;J Pedrosa;R A Silva

  • IFN-γ and NO in mycobacterial disease: new jobs for old hands

    Andrea M Cooper;Linda B Adams;Dyana K Dalton;Rui Appelberg

  • Neutrophils and intracellular pathogens: beyond phagocytosis and killing.

    Rui Appelberg

  • Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages.

    Avinash Sonawane;José Carlos Santos;Bibhuti B. Mishra;Prajna Jena

  • Survival of Mycobacterium avium and Mycobacterium tuberculosis in Acidified Vacuoles of Murine Macrophages

    Maria Salomé Gomes;Simon Paul;Andre L. Moreira;Rui Appelberg

  • Neutrophil-macrophage cooperation in the host defence against mycobacterial infections☆

    Manuel T. Silva;M.NazaréT. Silva;Rui Appelberg

  • Improved Clearance of Mycobacterium avium Upon Disruption of the Inducible Nitric Oxide Synthase Gene

    Gomes Ms;Flórido M;Pais Tf;Appelberg R

  • Susceptibility of beige mice to Mycobacterium avium: role of neutrophils.

    R Appelberg;A G Castro;S Gomes;J Pedrosa

  • Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages

    R Appelberg;I M Orme

  • CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis.

    J. Turner;C. D. D'Souza;J. E. Pearl;P. Marietta

  • Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine.

    Irene S. Leal;Birgitte Smedegård;Peter Andersen;Rui Appelberg

  • Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium

    M S Gomes;R Appelberg

  • Protective Role of Interferon Gamma, Tumor Necrosis Factor Alpha and Interleukin-6 in Mycobacterium tuberculosis and M. avium Infections

    Rui Appelberg

  • Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation.

    Irene S. Leal;Birgitte Smedegård;Peter Andersen;Rui Appelberg

  • Heme Catabolism by Heme Oxygenase-1 Confers Host Resistance to Mycobacterium Infection

    Sandro Silva-Gomes;Rui Appelberg;Rasmus Larsen;Miguel Parreira Soares

  • Characterization of the virulence of Mycobacterium avium complex (MAC) isolates in mice

    J. Pedrosa;M. Flórido;Z. M. Kunze;A. G. Castro

  • Susceptibility of Beige Mice toMycobacterium avium: Role of Neutrophils

    Rui Appelberg;Jorge Pedrosa;Andmanuel T. Silva

Frequent Co-Authors

Andrea M. Cooper
Andrea M. Cooper University of Leicester
Ian M. Orme
Ian M. Orme Colorado State University
Peter E. Andersen
Peter E. Andersen Technical University of Denmark
Michael B. Jordan
Michael B. Jordan Cincinnati Children's Hospital Medical Center
Richard L. Gallo
Richard L. Gallo University of California, San Diego
Germain Puzo
Germain Puzo Federal University of Toulouse Midi-Pyrénées
Miguel P. Soares
Miguel P. Soares Instituto Gulbenkian de Ciência
Johnjoe McFadden
Johnjoe McFadden University of Surrey
Stefan Ehlers
Stefan Ehlers Kiel University
Anne O'Garra
Anne O'Garra The Francis Crick Institute

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Related Online Degrees & Career Pathways

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Additionally, finding accelerated nursing programs near me is a practical step for students looking for accessible, on-site options that can jumpstart their careers. These pathways complement immunology studies by providing clinical experience and expanding career opportunities in healthcare settings.

Overall, combining immunology with nursing education offers a unique angle in both patient care and biomedical research, supporting a broad spectrum of rewarding career trajectories.

Best Scientists Citing Rui Appelberg