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D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
11880
World Ranking
12593
National Ranking
468

Overview

Patrick Midoux is affiliated with the University of Orléans in France. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a specialized emphasis on Molecular Biology, Genetics, Biomedical Engineering, Cancer Research, and Oncology.

The researcher's work spans several key topics including:

  • RNA Interference and Gene Delivery
  • Virus-based gene therapy research
  • Advanced biosensing and bioanalysis techniques
  • MicroRNA in disease regulation
  • CAR-T cell therapy research
  • RNA Research and Splicing
  • Nanopore and Nanochannel Transport Studies

Midoux has published multiple papers in several scientific venues. Frequent publication platforms include:

  • Molecular Therapy - Nucleic Acids
  • Macromolecular Bioscience
  • Pharmaceutics
  • Journal of Controlled Release
  • International Journal of Pharmaceutics

Their recent papers include:

  • Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles, 2021, Pharmaceutics
  • In Vivo bone tissue induction by freeze-dried collagen-nanohydroxyapatite matrix loaded with BMP2/NS1 mRNAs lipopolyplexes, 2021, Journal of Controlled Release
  • DNA nuclear targeting sequences for enhanced non-viral gene transfer: An in vitro and in vivo study, 2021, Molecular Therapy - Nucleic Acids
  • Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system, 2020, Journal of Controlled Release
  • DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer, 2022, Molecular Therapy - Nucleic Acids

Midoux collaborates frequently with several co-authors including:

  • Chantal Pichon
  • Tristan Montier
  • Philippe Guégan
  • Cristine Gonçalves
  • Federico Perche

The combination of these collaborations and contributions reflects an active engagement in ongoing gene delivery and molecular therapy research, with a focus on innovative approaches for RNA interference, targeted gene delivery, and cancer-related molecular mechanisms.

Best Publications

  • Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes

    Patrick Midoux;Michel Monsigny

  • Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

    Patrick Midoux;Chantal Pichon;Jean-Jacques Yaouanc;Paul-Alain Jaffrès

  • Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells.

    Patrick Midoux;Christina Mendes;Alain Legrand;Jacques Raimond

  • Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA/lactosylated polylysine complexes.

    Patrick Erbacher;Annie Claude Roche;Michel Monsigny;Patrick Midoux

  • Histidine-rich peptides and polymers for nucleic acids delivery.

    Chantal Pichon;Christine Gonçalves;Patrick Midoux

  • Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.

    Federico Perche;Thierry Benvegnu;Mathieu Berchel;Loic Lebegue

  • Membrane permeabilization and efficient gene transfer by a peptide containing several histidines.

    Patrick Midoux;Antoine Kichler;Valerie Boutin;Jean-Claude Maurizot

  • Polymer-based gene delivery: a current review on the uptake and intracellular trafficking of polyplexes.

    Patrick Midoux;Gilles Breuzard;Jean Pierre Gomez;Chantal Pichon

  • Nanoporous metal organic frameworks as hybrid polymer-metal composites for drug delivery and biomedical applications.

    Sarwar Beg;Mahfoozur Rahman;Atul Jain;Sumant Saini

  • Chemical vectors for gene delivery: uptake and intracellular trafficking.

    Chantal Pichon;Ludivine Billiet;Patrick Midoux

  • Sonoporation: mechanistic insights and ongoing challenges for gene transfer.

    Anthony Delalande;Spiros Kotopoulis;Michiel Postema;Patrick Midoux

  • Lipid-based mRNA vaccine delivery systems

    Patrick Midoux;Chantal Pichon

  • Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes

    Michel Monsigny;Annie-Claude Roche;Patrick Midoux;Roger Mayer

  • mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes

    M Mockey;E Bourseau;V Chandrashekhar;A Chaudhuri

  • Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages.

    Patrick Erbacher;Marie-Thérèse Bousser;Jacques Raimond;Michel Monsigny

  • Glycosylated polylysine/DNA complexes: gene transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size.

    Patrick Erbacher;Annie Claude Roche;Michel Monsigny;Patrick Midoux

  • Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells.

    Christine Gonçalves;Eric Mennesson;Renate Fuchs;Jean-Pierre Gorvel

  • mRNA transfection of dendritic cells: Synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level

    Michael Mockey;Cristine Gonçalves;Franck P. Dupuy;François M. Lemoine

  • EXPRESSION OF A MANNOSE/FUCOSE MEMBRANE LECTIN ON HUMAN DENDRITIC CELLS

    Alexandre Avraméas;Dorian McIlroy;Anne Hosmalin;Brigitte Autran

  • Sugar-specific endocytosis of glycoproteins by Lewis lung carcinoma cells.

    A. C. Roche;M. Barzilay;P. Midoux;S. Junqua

Frequent Co-Authors

Chantal Pichon
Chantal Pichon University of Orléans
Michel Monsigny
Michel Monsigny University of Orléans
Ayache Bouakaz
Ayache Bouakaz François Rabelais University
Bernard Valeur
Bernard Valeur Conservatoire National des Arts et Métiers
Jan Balzarini
Jan Balzarini KU Leuven
Daniel Scherman
Daniel Scherman Université Paris Cité
Brigitte Autran
Brigitte Autran Sorbonne University
Hamida Hammad
Hamida Hammad Ghent University
Raymond M. Schiffelers
Raymond M. Schiffelers Utrecht University
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research

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