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Paola Picotti

Paola Picotti

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
17978
World Ranking
13570
National Ranking
243

Research.com Recognitions

  • 2020 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Genetics/Molecular Biology and Cell Biology

Overview

Paola Picotti is affiliated with ETH Zurich in Switzerland and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, spectroscopy, neurology, physiology, and genetics, reflecting a broad interdisciplinary approach.

The main topics of their work involve advanced proteomics techniques and applications, research on Alzheimer's disease, studies of Parkinson's disease mechanisms and treatments, as well as investigations into connexins and lens biology. Other notable subjects include research on Yersinia bacterium, plague, ectoparasites, enzyme structure and function, and computational drug discovery methods.

Frequent co-authors in their publications include Natalie de Souza, Dina Schuster, Volodymyr M. Korkhov, Ilaria Piazza, and Valentina Cappelletti, highlighting a collaborative research environment.

The scientist has published numerous works in prominent venues such as bioRxiv (Cold Spring Harbor Laboratory), eLife, Nature Communications, Molecular Systems Biology, and Nature Chemical Biology.

Recent papers authored or co-authored by Paola Picotti include:

  • "A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes" (2020, Nature Communications)
  • "Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ" (2020, Cell)
  • "Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications" (2022, Nature Protocols)
  • "Systematic detection of functional proteoform groups from bottom-up proteomic datasets" (2021, Nature Communications)
  • "protti: an R package for comprehensive data analysis of peptide- and protein-centric bottom-up proteomics data" (2021, Bioinformatics Advances)

Paola Picotti's work has been recognized at the national level, notably through the German National Academy of Sciences Leopoldina, which awarded them in 2020 for contributions in genetics, molecular biology, and cell biology.

Best Publications

  • L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.

    Roger Geiger;Roger Geiger;Jan C. Rieckmann;Tobias Wolf;Tobias Wolf;Camilla Basso

  • SELECTED REACTION MONITORING FOR QUANTITATIVE PROTEOMICS: A TUTORIAL

    Vinzenz Lange;Paola Picotti;Bruno Domon;Ruedi Aebersold

  • Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions

    Paola Picotti;Ruedi Aebersold;Ruedi Aebersold

  • Full Dynamic Range Proteome Analysis of S. cerevisiae by Targeted Proteomics

    Paola Picotti;Bernd Bodenmiller;Lukas N. Mueller;Bruno Domon

  • Probing protein structure by limited proteolysis.

    Angelo Fontana;Patrizia Polverino de Laureto;Barbara Spolaore;Erica Frare

  • High-throughput generation of selected reaction-monitoring assays for proteins and proteomes.

    Paola Picotti;Oliver Rinner;Robert Stallmach;Franziska Dautel

  • mProphet: automated data processing and statistical validation for large-scale SRM experiments

    Lukas Reiter;Oliver Rinner;Paola Picotti;Paola Picotti;Ruth Hüttenhain

  • A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication

    Ilaria Piazza;Karl Kochanowski;Valentina Cappelletti;Tobias Fuhrer

  • Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability

    Pascal Leuenberger;Pascal Leuenberger;Stefan Ganscha;Stefan Ganscha;Abdullah Kahraman;Valentina Cappelletti

  • Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast

    Bernd Bodenmiller;Stefanie Wanka;Claudine Kraft;Joerg Urban

  • A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis

    Paola Picotti;Mathieu Clément-Ziza;Hugo Y K Lam;David S Campbell

  • Global analysis of protein structural changes in complex proteomes

    Yuehan Feng;Giorgia De Franceschi;Abdullah Kahraman;Martin Soste

  • Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome

    Ulrike Kusebauch;David S. Campbell;Eric W. Deutsch;Caroline S. Chu

  • Host Cell Entry of Respiratory Syncytial Virus Involves Macropinocytosis Followed by Proteolytic Activation of the F Protein

    Magdalena Anna Krzyzaniak;Michael Thomas Zumstein;Juan Atilio Gerez;Paola Picotti

  • Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.

    Edward Rockenstein;Silke Nuber;Cassia R. Overk;Kiren Ubhi

  • PhosphoPep--a database of protein phosphorylation sites in model organisms.

    Bernd Bodenmiller;David Campbell;Bertran Gerrits;Henry H N Lam

  • The Implications of Proteolytic Background for Shotgun Proteomics

    Paola Picotti;Ruedi Aebersold;Ruedi Aebersold;Bruno Domon

  • A database of mass spectrometric assays for the yeast proteome

    Paola Picotti;Henry H N Lam;Henry H N Lam;David Campbell;Eric W. Deutsch

  • Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry.

    Simone Schopper;Abdullah Kahraman;Pascal Leuenberger;Yuehan Feng

  • Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer

    Igor Cima;Ralph Schiess;Peter Wild;Martin Kaelin

Frequent Co-Authors

Matthias Peter
Matthias Peter ETH Zurich
Bernd Bodenmiller
Bernd Bodenmiller University of Zurich
Uwe Sauer
Uwe Sauer ETH Zurich
Angelo Fontana
Angelo Fontana National Academies of Sciences, Engineering, and Medicine
Julio Saez-Rodriguez
Julio Saez-Rodriguez Heidelberg University
Eric W. Deutsch
Eric W. Deutsch University of Washington
Nicola Zamboni
Nicola Zamboni ETH Zurich
Matthias Heinemann
Matthias Heinemann University of Groningen
Roland Riek
Roland Riek ETH Zurich

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