World's Best Scientists 2026 revealed!
Olivier Barbier

Olivier Barbier

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
9333
World Ranking
17610
National Ranking
613

Overview

Olivier Barbier is affiliated with Université Laval in Canada and has a focused research profile in the field of medicine, with a total of 83 publications. Their work spans several subfields including epidemiology, surgery, oncology, hepatology, and molecular biology.

The scientist's research primarily addresses topics related to liver disease diagnosis and treatment, drug transport and resistance mechanisms, and liver diseases combined with immune system interactions. Additional areas of interest include diet and metabolism studies, the intersection of diet, metabolism, and disease, cholesterol and lipid metabolism, as well as pharmacogenetics and drug metabolism.

Olivier Barbier has contributed to multiple recent academic papers, demonstrating continued activity in the field. Some notable publications include:

  • Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice (2022, Nature Communications)
  • High-Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease (2020, Hepatology Communications)
  • S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes (2020, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease)
  • PPAR-Mediated Bile Acid Glucuronidation: Therapeutic Targets for the Treatment of Cholestatic Liver Diseases (2024, Cells)
  • Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis (2021, Hepatology Communications)

Their frequent collaborators include Jocelyn Trottier, Mélanie Verreault, André Marette, Marie-Claude Vohl, and Andrea Lavoie, with whom they have co-authored multiple studies.

Olivier Barbier often publishes in specialized scientific journals relevant to their fields of study. The main publication venues include:

  • Journal of Hepatology
  • American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Nutrients
  • Hepatology Communications
  • Drug Metabolism and Disposition

Best Publications

  • Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation.

    Christophe Blanquart;Olivier Barbier;Jean Charles Fruchart;Bart Staels

  • Glucose regulates the expression of the farnesoid X receptor in liver.

    Daniel Duran-Sandoval;Gisèle Mautino;Geneviève Martin;Fréderic Percevault

  • Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

    Thierry Claudel;Thierry Claudel;Yusuke Inoue;Olivier Barbier;Olivier Barbier;Daniel Duran-Sandoval;Daniel Duran-Sandoval

  • Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans

    Alain Bélanger;Georges Pelletier;Fernand Labrie;Olivier Barbier

  • Treatment With Camu Camu ( Myrciaria dubia) Prevents Obesity by Altering the Gut Microbiota and Increasing Energy Expenditure in Diet-Induced Obese Mice

    Fernando F Anhê;Renato T Nachbar;Thibault V Varin;Jocelyn Trottier

  • FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.

    Olivier Barbier;Ines Pineda Torra;Audrey Sirvent;Thierry Claudel

  • 3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).

    Olivier Barbier;David Turgeon;Caroline Girard;Mitchell D. Green

  • PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a

    Florence Gizard;Carole Amant;Olivier Barbier;Stefano Bellosta

  • Acute Antiinflammatory Properties of Statins Involve Peroxisome Proliferator–Activated Receptor-α via Inhibition of the Protein Kinase C Signaling Pathway

    Réjane Paumelle;Christophe Blanquart;Olivier Briand;Olivier Barbier

  • Peroxisome Proliferator-activated Receptor α Induces Hepatic Expression of the Human Bile Acid Glucuronidating UDP-glucuronosyltransferase 2B4 Enzyme

    Olivier Barbier;Daniel Duran-Sandoval;Inés Pineda-Torra;Vladimir Kosykh

  • Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay.

    Li Zhang;Zhihong Yang;Jocelyn Trottier;Olivier Barbier

  • Peroxisome Proliferator-activated Receptor α (PPARα) Turnover by the Ubiquitin-Proteasome System Controls the Ligand-induced Expression Level of Its Target Genes

    Christophe Blanquart;Olivier Barbier;Jean-Charles Fruchart;Bart Staels

  • The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.

    Olivier Barbier;Lyne Villeneuve;Virginie Bocher;Coralie Fontaine

  • Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor α activation

    Kathy Senekeo-Effenberger;Shujuan Chen;Erin Brace-Sinnokrak;Jessica A. Bonzo

  • Characterization of UDP-glucuronosyltransferases active on steroid hormones.

    Dean W. Hum;Alain Bélanger;Éric Lévesque;Olivier Barbier

  • Tissue-specific, Inducible, and Hormonal Control of the Human UDP-Glucuronosyltransferase-1 (UGT1) Locus *

    Shujuan Chen;Deirdre Beaton;Nghia Nguyen;Kathy Senekeo-Effenberger

  • H19 promotes cholestatic liver fibrosis by preventing ZEB1‐mediated inhibition of epithelial cell adhesion molecule

    Yongfeng Song;Chune Liu;Xia Liu;Jocelyn Trottier

  • UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 Enzymes Are Major Determinants of the Androgen Response in Prostate Cancer LNCaP Cells

    Sarah Chouinard;Olivier Barbier;Alain Bélanger

  • Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver

    Jocelyn Trottier;Mélanie Verreault;Susan Grepper;Didier Monté

  • Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)

    Shujuan Chen;Mei-Fei Yueh;Cyril Bigo;Olivier Barbier

Frequent Co-Authors

Alain Bélanger
Alain Bélanger Université Laval
Bart Staels
Bart Staels University of Lille
André Marette
André Marette Université Laval
Robert H. Tukey
Robert H. Tukey University of California, San Diego
Chantal Guillemette
Chantal Guillemette Université Laval
Valéry Legrain
Valéry Legrain Université Catholique de Louvain
Jean-Charles Fruchart
Jean-Charles Fruchart Institut Pasteur
Georges Pelletier
Georges Pelletier Université Laval
Li Wang
Li Wang Yale University
Ladan Fazli
Ladan Fazli University of British Columbia

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