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Biology and Biochemistry

D-Index
62
Citations
14728
World Ranking
10732
National Ranking
4658

Overview

Michael Cashel is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with notable contributions in molecular biology, genetics, ecology, materials chemistry, and cell biology.

The scientist's work encompasses several main topics including bacterial genetics and biotechnology, RNA and protein synthesis mechanisms, bacteriophages and microbial interactions, enzyme structure and function, DNA repair mechanisms, DNA and nucleic acid chemistry, and metabolomics and mass spectrometry studies.

They have authored multiple research papers, including:

  • The Absence of (p)ppGpp Renders Initiation of Escherichia coli Chromosomal DNA Synthesis Independent of Growth Rates, 2020, published in mBio
  • Possible Roles for Basal Levels of (p)ppGpp: Growth Efficiency Vs. Surviving Stress, 2020, published in Frontiers in Microbiology
  • Estimates of RelSeq, Mesh1, and SAHMex Hydrolysis of (p)ppGpp and (p)ppApp by Thin Layer Chromatography and NADP/NADH Coupled Assays, 2020, published in Frontiers in Microbiology
  • The secondary messenger ppGpp interferes with cAMP-CRP regulon by promoting CRP acetylation in Escherichia coli, 2021, published in PLoS ONE
  • Mutational analysis of Escherichia coli GreA protein reveals new functional activity independent of antipause and lethal when overexpressed, 2020, published in Scientific Reports

Frequent coauthors of Michael Cashel include:

  • Llorenç Fernández-Coll
  • Katarzyna Potrykus
  • Agnieszka Szalewska-Pałasz
  • Monika Maciąg-Dorszyńska
  • Krishma Tailor

Their publications are often found in journals such as Frontiers in Microbiology, mBio, PLoS ONE, Scientific Reports, and the International Journal of Molecular Sciences. Among these, Frontiers in Microbiology is the most frequent venue with three publications.

Best Publications

  • (p)ppGpp: still magical?

    Katarzyna Potrykus;Michael Cashel

  • Two compounds implicated in the function of the RC gene of Escherichia coli.

    Michael Cashel;Michael Cashel;Jonathan Gallant

  • Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.

    Hua Xiao;Miklos Kalman;Kenji Ikehara;Sharon Zemel

  • The Control of Ribonucleic Acid Synthesis in Escherichia coli: IV. RELEVANCE OF UNUSUAL PHOSPHORYLATED COMPOUNDS FROM AMINO ACID-STARVED STRINGENT STRAINS

    Michael Cashel

  • Synthesis of the stationary-phase sigma factor sigma s is positively regulated by ppGpp.

    D R Gentry;V J Hernandez;L H Nguyen;D B Jensen

  • Regulation of Bacterial ppGpp and pppGpp

    Michael Cashel

  • An improved method for thin-layer chromatography of nucleotide mixtures containing32P-labeled orthophosphate

    Michael Cashel;Robert A. Lazzarini;Barbara Kalbacher

  • The Control of Ribonucleic Acid Synthesis in Escherichia coli V. CHARACTERIZATION OF A NUCLEOTIDE ASSOCIATED WITH THE STRINGENT RESPONSE

    Michael Cashel;Barbara Kalbacher

  • On the regulation of guanosine tetraphosphate levels in stringent and relaxed strains of Escherichia coli.

    Robert A. Lazzarini;Michael Cashel;Jonathan Gallant

  • Conformational Antagonism between Opposing Active Sites in a Bifunctional RelA/SpoT Homolog Modulates (p)ppGpp Metabolism during the Stringent Response

    Tanis Hogg;Undine Mechold;Horst Malke;Mike Cashel

  • Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli

    Akio Kuroda;Helen Murphy;Michael Cashel;Arthur Kornberg

  • Iron limitation induces SpoT-dependent accumulation of ppGpp in Escherichia coli.

    Daniel Vinella;Christian Albrecht;Michael Cashel;Richard D’Ari

  • ppGpp is the major source of growth rate control in E. coli

    Katarzyna Potrykus;Helen Murphy;Nadège Philippe;Michael Cashel

  • Overexpression of the relA gene in Escherichia coli.

    G Schreiber;S Metzger;E Aizenman;S Roza

  • Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilis.

    Undine Mechold;Helen Murphy;Larissa Brown;Michael Cashel

  • DksA Affects ppGpp Induction of RpoS at a Translational Level

    Larissa Brown;Daniel Gentry;Thomas Elliott;Michael Cashel

  • Differential stringent control of the tandem E. coli ribosomal RNA promoters from the rrnA operon expressed in vivo in multicopy plasmids

    Paolo Sarmientos;James E. Sylvester;Sara Contente;Michael Cashel

  • Basal ppGpp level adjustment shown by new spoT mutants affect steady state growth rates and rrnA ribosomal promoter regulation in Escherichia coli

    Edoardo Sarubbi;Kenneth E. Rudd;Michael Cashel

  • Differential regulation by ppGpp versus pppGpp in Escherichia coli

    Undine Mechold;Katarzyna Potrykus;Helen Murphy;Katsuhiko S. Murakami

  • Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli.

    A.L. Svitil;M. Cashel;J.W. Zyskind

Frequent Co-Authors

Ernst Freese
Ernst Freese MRC Laboratory of Molecular Biology
Katsuhiko S. Murakami
Katsuhiko S. Murakami Pennsylvania State University
Hua Xiao
Hua Xiao Michigan State University
Gideon Schreiber
Gideon Schreiber Weizmann Institute of Science
Xuhui Huang
Xuhui Huang University of Wisconsin–Madison
Robert A. Lazzarini
Robert A. Lazzarini Icahn School of Medicine at Mount Sinai
Tony Romeo
Tony Romeo University of Florida
Ernest Hamel
Ernest Hamel National Institutes of Health
Lynn W. Enquist
Lynn W. Enquist Princeton University
David I. Friedman
David I. Friedman University of Michigan–Ann Arbor

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