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Laurence Van Melderen

Laurence Van Melderen

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
11084
World Ranking
18264
National Ranking
302

Overview

Laurence Van Melderen is affiliated with the Université Libre de Bruxelles in Belgium and is actively engaged in research within the fields of Biochemistry, Genetics, and Molecular Biology. Their work prominently focuses on genetics, endocrinology, molecular biology, molecular medicine, and biomedical engineering.

The scientist's research topics include:

  • Bacterial Genetics and Biotechnology
  • Vibrio bacteria research studies
  • Antibiotic Resistance in Bacteria
  • Bacteriophages and microbial interactions
  • Bacterial biofilms and quorum sensing
  • RNA and protein synthesis mechanisms
  • Burkholderia infections and melioidosis

Recent publications by Van Melderen and collaborators cover a range of topics related to bacterial toxin-antitoxin systems and bacterial behavior. Notable papers include:

  • "Biology and evolution of bacterial toxin-antitoxin systems," 2022, published in Nature Reviews Microbiology
  • "Type II Toxin-Antitoxin Systems: Evolution and Revolutions," 2020, published in Journal of Bacteriology
  • "Toxin-Antitoxin Gene Pairs Found in Tn 3 Family Transposons Appear To Be an Integral Part of the Transposition Module," 2020, published in mBio
  • "The Variety in the Common Theme of Translation Inhibition by Type II Toxin-Antitoxin Systems," 2020, published in Frontiers in Genetics
  • "Bacterial behavior in human blood reveals complement evaders with some persister-like features," 2020, published in PLoS Pathogens

Van Melderen frequently collaborates with a set of researchers including:

  • Nathan Fraikin
  • Frédéric Goormaghtigh
  • Dukas Jurėnas
  • Julien Cayron
  • Thierry Oms

Their publications are often found in journals such as mBio, bioRxiv (Cold Spring Harbor Laboratory), Nature Reviews Microbiology, Journal of Bacteriology, and Nucleic Acids Research. Van Melderen has contributed multiple papers in these venues, demonstrating a focus on microbiology and molecular bacterial genetics.

Best Publications

  • Definitions and guidelines for research on antibiotic persistence

    Naomi N.Q. Balaban;Sophie Helaine;Kim Lewis;Martin Ackermann;Martin Ackermann

  • Bacterial toxin-antitoxin systems: more than selfish entities?

    Laurence Van Melderen;Manuel Saavedra De Bast

  • Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

    Raphaël Leplae;Damien Geeraerts;Régis Hallez;Julien Guglielmini

  • Toxin-antitoxin systems: why so many, what for?

    Laurence Van Melderen

  • A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

    Martina L Sanderson-Smith;David M P De Oliveira;Julien Guglielmini;David J McMillan

  • The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase.

    Philippe Bernard;Katherine E. Kézdy;Laurence Van Melderen;Jan Steyaert

  • Lon‐dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid‐free segregant bacteria

    Laurence Van Melderen;Philippe Bernard;Martine Couturier

  • Toxins-antitoxins: Diversity, evolution and function

    Finbarr Hayes;Laurence Van Melderen

  • Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system.

    Susanne K. Christensen;Geneviève Maenhaut-Michel;Natacha Mine;Susan Gottesman

  • ATP-dependent degradation of CcdA by Lon protease. Effects of secondary structure and heterologous subunit interactions

    Laurence Van Melderen;Minh Hoa Dao Thi;Paolo Lecchi;Susan Gottesman

  • What Is the Benefit to Escherichia coli of Having Multiple Toxin-Antitoxin Systems in Its Genome?

    Virginie Tsilibaris;Geneviève Maenhaut-Michel;Natacha Mine;Laurence Van Melderen

  • Biological roles of the Lon ATP-dependent protease.

    Virginie Tsilibaris;Geneviève Maenhaut-Michel;Laurence Van Melderen

  • Toxin-antitoxin systems as multilevel interaction systems.

    Nathalie Goeders;Laurence Van Melderen

  • The Staphylococci phages family: an overview.

    Marie Deghorain;Laurence Van Melderen

  • Post-transcriptional global regulation by CsrA in bacteria

    Johan Timmermans;Laurence Van Melderen

  • Type II Toxin-Antitoxin Systems: Evolution and Revolutions.

    Nathan Fraikin;Frédéric Goormaghtigh;Laurence Van Melderen

  • Reassessing the Role of Type II Toxin-Antitoxin Systems in Formation of Escherichia coli Type II Persister Cells

    Frédéric Goormaghtigh;Nathan Fraikin;Marta Putrinš;Thibaut Hallaert

  • The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system.

    Hassan Afif;Noureddine Allali;Martine Couturier;Laurence Van Melderen

  • Molecular basis of gyrase poisoning by the addiction toxin CcdB.

    Minh-Hoa Dao-Thi;Laurence Van Melderen;Erwin De Genst;Hassan Afif

  • What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome? Commentary

    Roy David Magnuson;Virginie Tsilibaris;Geneviève Maenhaut-Michel;Natacha Mine

Frequent Co-Authors

Remy Loris
Remy Loris Vrije Universiteit Brussel
Lode Wyns
Lode Wyns Vrije Universiteit Brussel
Abram Aertsen
Abram Aertsen KU Leuven
Frank Sobott
Frank Sobott University of Leeds
Tanel Tenson
Tanel Tenson University of Tartu
Susan Gottesman
Susan Gottesman National Institutes of Health
Didier Mazel
Didier Mazel Université Paris Cité
Michael Chandler
Michael Chandler Georgetown University Medical Center

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