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Raghavan Varadarajan

Raghavan Varadarajan

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
7082
World Ranking
18980
National Ranking
95

Overview

Raghavan Varadarajan is affiliated with the Indian Institute of Science in India and has contributed extensively to fields including Biochemistry, Genetics, and Molecular Biology, with 83 publications, and Medicine, with 75 publications. Their work spans several subfields such as Molecular Biology, Infectious Diseases, Genetics, Epidemiology, and Radiology, Nuclear Medicine, and Imaging.

The main topics Varadarajan has researched include SARS-CoV-2 and COVID-19, bacterial genetics and biotechnology, monoclonal and polyclonal antibodies research, RNA and protein synthesis mechanisms, bacteriophages and microbial interactions, protein structure and dynamics, and viral gastroenteritis research and epidemiology.

Varadarajan's recent publications feature:

  • Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment, 2020, Journal of Biological Chemistry
  • VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response, 2020, Science Advances
  • VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis, 2020, Frontiers in Microbiology
  • A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern, 2021, Frontiers in Immunology
  • Prediction of Residue-specific Contributions to Binding and Thermal Stability Using Yeast Surface Display, 2022, Frontiers in Molecular Biosciences

The frequent coauthors in Varadarajan's work include Randhir Singh, Shahbaz Ahmed, Munmun Bhasin, Gopinath Chattopadhyay, and Rajesh P. Ringe, indicating collaborative research efforts across multiple projects.

Varadarajan's research is published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Frontiers in Molecular Biosciences, Viruses, and the Journal of Virology. The scientist has 21 publications in bioRxiv and four in Nature Communications among others, reflecting a wide dissemination of research findings.

Best Publications

  • Elucidation of factors responsible for enhanced thermal stability of proteins: a structural genomics based study.

    Suvobrata Chakravarty;Raghavan Varadarajan

  • Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

    Gayathri Bommakanti;Michael P Citron;Robert W Hepler;Cheryl Callahan

  • Residue depth: a novel parameter for the analysis of protein structure and stability

    Suvobrata Chakravarty;Raghavan Varadarajan

  • Elucidation of determinants of protein stability through genome sequence analysis.

    Suvobrata Chakravarty;Raghavan Varadarajan;Raghavan Varadarajan

  • Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection.

    Vamsee V. A. Mallajosyula;Michael Citron;Francesca Ferrara;Xianghan Lu

  • Depth: a web server to compute depth, cavity sizes, detect potential small-molecule ligand-binding cavities and predict the pKa of ionizable residues in proteins

    Kuan Pern Tan;Thanh Binh Nguyen;Siddharth Patel;Raghavan Varadarajan

  • Effects of buried ionizable amino acids on the reduction potential of recombinant myoglobin

    Raghavan Varadarajan;Thomas E. Zewert;Harry B. Gray;Steven G. Boxer

  • Thermodynamics of protein-peptide interactions in the ribonuclease S system studied by titration calorimetry.

    Patrick R. Connelly;Raghavan Varadarajan;Julian M. Sturtevant;Frederic M. Richards

  • Cloning, expression in Escherichia coli, and reconstitution of human myoglobin.

    Raghavan Varadarajan;Alex Szabo;Steven G. Boxer

  • Refinement of the crystal structure of ribonuclease S. Comparison with and between the various ribonuclease A structures.

    Eunice E. Kim;Raghavan Varadarajan;Harold W. Wyckoff;Frederic M. Richards

  • Heat capacity changes for protein-peptide interactions in the ribonuclease S system.

    Raghavan Varadarajan;Patrick R. Connelly;Julian M. Sturtevant;Frederic M. Richards

  • Stalking influenza by vaccination with pre-fusion headless HA mini-stem

    Sophie A Valkenburg;Sophie A Valkenburg;V Vamsee Aditya Mallajosyula;Olive T W Li;Alex W H Chin

  • Thermodynamic characterization of the reversible, two-state unfolding of maltose binding protein, a large two-domain protein

    C. Ganesh;Aseema N. Shah;C. P. Swaminathan;and Avadhesha Surolia

  • MODIP revisited: re-evaluation and refinement of an automated procedure for modeling of disulfide bonds in proteins

    Vardhan S. Dani;C. Ramakrishnan;Raghavan Varadarajan

  • MazF-induced Growth Inhibition and Persister Generation in Escherichia coli

    Arti Tripathi;Pooja C. Dewan;Shahbaz A. Siddique;Raghavan Varadarajan;Raghavan Varadarajan

  • Electrostatic Interactions in Wild-Type and Mutant Recombinant Human Myoglobins+

    Raghavan Varadarajan;David G. Lambright;Steven G. Boxer

  • Binding of nucleobases with single-walled carbon nanotubes: Theory and experiment

    Anindya Das;A.K. Sood;Prabal K. Maiti;Mili Das

  • Crystallographic structures of ribonuclease S variants with nonpolar substitution at position 13: packing and cavities.

    R Varadarajan;F.M. Richards

  • A rapid, efficient, and economical inverse polymerase chain reaction-based method for generating a site saturation mutant library.

    Pankaj C Jain;Raghavan Varadarajan;Raghavan Varadarajan

  • Effect of Signal Peptide on Stability and Folding of Escherichia coli Thioredoxin

    Pranveer Singh;Likhesh Sharma;S. Rajendra Kulothungan;Bharat V. Adkar

Frequent Co-Authors

Avadhesha Surolia
Avadhesha Surolia Indian Institute of Science
David C. Montefiori
David C. Montefiori Duke University
Jayant B. Udgaonkar
Jayant B. Udgaonkar Indian Institute of Science Education and Research Pune
Munishwar N. Gupta
Munishwar N. Gupta Indian Institute of Technology Delhi
Frederic M. Richards
Frederic M. Richards Yale University
Celia C. LaBranche
Celia C. LaBranche Duke University
Julian M. Sturtevant
Julian M. Sturtevant Yale University
Rama Rao Amara
Rama Rao Amara Emory University
Nigel J. Temperton
Nigel J. Temperton University of Kent
K. VijayRaghavan
K. VijayRaghavan National Centre for Biological Sciences

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