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D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
13734
World Ranking
17454
National Ranking
1372

Overview

Paul A.W. Edwards is affiliated with the University of Cambridge in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant work in Molecular Biology, Surgery, Pulmonary and Respiratory Medicine, Oncology, and Cancer Research.

The scientist's work focuses on several main topics, including:

  • Esophageal Cancer Research and Treatment
  • Cancer Genomics and Diagnostics
  • Genetic factors in colorectal cancer
  • Lung Cancer Treatments and Mutations
  • Genomic variations and chromosomal abnormalities
  • RNA modifications and cancer
  • BRCA gene mutations in cancer

An overview of recent publications highlights the diversity and scope of their research contributions:

  • "Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition," 2020, Nature Genetics
  • "Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer," 2020, Nature Genetics
  • "Genomic footprints of activated telomere maintenance mechanisms in cancer," 2020, Nature Communications
  • "Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data," 2020, Gastroenterology
  • "Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line," 2020, Communications Biology

Frequent publication venues also provide context on where their work is typically disseminated. These venues include:

  • Nature Genetics
  • Nature Communications
  • Communications Biology
  • Oral Surgery Oral Medicine Oral Pathology and Oral Radiology
  • Gastroenterology

Paul A.W. Edwards has collaborated frequently with a group of researchers in related fields. Notable coauthors include:

  • Rebecca C. Fitzgerald
  • Matthew Eldridge
  • Gianmarco Contino
  • Ginny Devonshire
  • J. Robert O'Neill

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

    Peter J Campbell;Philip J Stephens;Erin D Pleasance;Sarah O'Meara

  • Complex multi-enhancer contacts captured by genome architecture mapping

    Robert A. Beagrie;Antonio Scialdone;Markus Schueler;Dorothee C. A. Kraemer

  • Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.

    Bernardo Rodriguez-Martin;Bernardo Rodriguez-Martin;Eva G. Alvarez;Eva G. Alvarez;Adrian Baez-Ortega;Jorge Zamora

  • Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

    Jamie M J Weaver;Caryn S Ross-Innes;Nicholas Shannon;Andy G Lynch

  • Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

    Maria Secrier;Xiaodun Li;Nadeera de Silva;Matthew D Eldridge

  • Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation

    Jean Robinson;Colin Sieff;Domenico Delia;Paul A. W. Edwards

  • Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism.

    Danielle K Lynch;Christine A Ellis;Paul Aw Edwards;Ian D Hiles

  • Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

    Tamir Chandra;Kristina Kirschner;Jean Yves Thuret;Benjamin D. Pope

  • Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells

    Annette S. Little;Kathryn Balmanno;Matthew J. Sale;Scott Newman

  • Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution

    Graham R. Bignell;Thomas Santarius;Jessica C.M. Pole;Adam P. Butler

  • Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

    Kadir C Akdemir;Victoria T Le;Sahaana Chandran;Yilong Li

  • Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement

    Wael M. Abdel-Rahman;Kanade Katsura;Willem Rens;Patricia A. Gorman

  • A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes.

    Maria J Garcia;Jessica C M Pole;Suet-Feung Chin;Andrew Teschendorff

  • Fusion genes and chromosome translocations in the common epithelial cancers.

    Paul A W Edwards

  • Wnt-4 Expression Induces a Pregnancy-like Growth Pattern in Reconstituted Mammary Glands in Virgin Mice

    Jane M. Bradbury;Paul A.W. Edwards;Christina C. Niemeyer;Trevor C. Dale

  • Estimation of rearrangement phylogeny for cancer genomes

    Chris D. Greenman;Chris D. Greenman;Erin D. Pleasance;Scott Newman;Fengtang Yang

  • Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity

    Jiyoung Kim;René Villadsen;Therese Sørlie;Louise Fogh

  • High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation.

    J C M Pole;C Courtay-Cahen;C Courtay-Cahen;M J Garcia;K A Blood

  • Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance (vol 48, pg 1131, 2016)

    Maria Secrier;Xiaodun Li;Nadeera de Silva;Matthew D Eldridge

Frequent Co-Authors

Carlos Caldas
Carlos Caldas University of Cambridge
Rebecca C. Fitzgerald
Rebecca C. Fitzgerald University of Cambridge
Simon Tavaré
Simon Tavaré Columbia University
Suet-Feung Chin
Suet-Feung Chin University of Cambridge
Peter J. Campbell
Peter J. Campbell Wellcome Sanger Institute
Graham R. Bignell
Graham R. Bignell Wellcome Sanger Institute
Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Kevin L. Howe
Kevin L. Howe European Bioinformatics Institute
Adam Butler
Adam Butler Wellcome Sanger Institute
Peter Van Loo
Peter Van Loo The Francis Crick Institute

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