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Kwang Chul Chung

Kwang Chul Chung

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
7675
World Ranking
16374
National Ranking
194

Overview

Kwang Chul Chung is affiliated with Yonsei University in South Korea and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work focuses on several interrelated subfields including Molecular Biology, Epidemiology, Neurology, Cell Biology, and Physiology.

The research conducted by Chung spans multiple topics with a strong emphasis on cellular and molecular mechanisms, particularly in disease contexts. Key topics covered in their publications include:

  • Autophagy in Disease and Therapy
  • Ubiquitin and Proteasome Pathways
  • Parkinson's Disease Mechanisms and Treatments
  • Endoplasmic Reticulum Stress and Disease
  • Alzheimer's Disease Research and Treatments
  • RNA Regulation and Disease
  • Down Syndrome and Intellectual Disability Research

Chung's recent publications illustrate their focus on neurodegenerative diseases and cellular proteostasis systems. Notable papers include:

  • "The central regulator p62 between ubiquitin proteasome system and autophagy and its role in the mitophagy and Parkinson's disease" (2020, BMB Reports)
  • "Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1" (2020, Cell Death and Disease)
  • "Precise control of mitophagy through ubiquitin proteasome system and deubiquitin proteases and their dysfunction in Parkinson's disease" (2021, BMB Reports)
  • "Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells" (2020, Experimental Neurobiology)
  • "Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation" (2020, Journal of Biological Chemistry)

The scientist frequently publishes in journals including:

  • Journal of Biological Chemistry
  • BMB Reports
  • PLoS ONE
  • Cell Death and Disease
  • Experimental Neurobiology

Chung collaborates often with a group of coauthors who have contributed to multiple publications together. Key frequent coauthors are:

  • Woo Hyun Shin
  • Su Hyoun Lee
  • Joon Hyung Park
  • Ye Hyung Lee
  • Ga Hyun Park

Overall, their research integrates fundamental molecular biology approaches with clinical relevance, especially targeting mechanisms that underlie neurodegenerative diseases such as Parkinson's and Alzheimer's disease. The scope of their studies also extends toward understanding autophagy regulation, ubiquitin-proteasome pathways, and cellular stress responses.

Best Publications

  • Interleukin-1β and Tumor Necrosis Factor-α Induce MUC5AC Overexpression through a Mechanism Involving ERK/p38 Mitogen-activated Protein Kinases-MSK1-CREB Activation in Human Airway Epithelial Cells *

    Kyoung Seob Song;Won Jae Lee;Kwang Chul chung;Ja Seok Koo

  • Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein *

    Jee Young Sung;Jongsun Kim;Seung R. Paik;Jeon Han Park

  • Proteolytic Cleavage of Extracellular Secreted α-Synuclein via Matrix Metalloproteinases

    Jee Young Sung;Sung Min Park;Choong Hwan Lee;Ji Won Um

  • Function and regulation of Dyrk1A: towards understanding Down syndrome

    Joongkyu Park;Woo Joo Song;Kwang Chul Chung

  • Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.

    Eun Jin Yang;Young Soo Ahn;Kwang Chul Chung

  • α-Synuclein Interacts with Phospholipase D Isozymes and Inhibits Pervanadate-induced Phospholipase D Activation in Human Embryonic Kidney-293 Cells

    Bong-Hyun Ahn;Hyangshuk Rhim;Shi Yeon Kim;Young-Mo Sung

  • Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

    Su Ryeon Seo;Seon Ah Chong;Syng Ill Lee;Jee Young Sung

  • Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein.

    Keun Jae Ahn;Seung R. Paik;Kwang Chul Chung;Jongsun Kim

  • DYRK1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

    Joongkyu Park;Yohan Oh;Lang Yoo;Min Su Jung

  • On the mechanism of internalization of α‐synuclein into microglia: roles of ganglioside GM1 and lipid raft

    Ji Young Park;Kwang Soo Kim;Saet Byul Lee;Jae Sung Ryu

  • Functional modulation of parkin through physical interaction with SUMO‐1

    Ji Won Um;Kwang Chul Chung

  • Dyrk1A Phosphorylates α-Synuclein and Enhances Intracellular Inclusion Formation

    Eun Joo Kim;Jee Young Sung;Hyun Jung Lee;Hyewhon Rhim

  • Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells

    Dongyeon Kim;Ahyoung Hong;Hye In Park;Woo Hyun Shin

  • Parkin ubiquitinates and promotes the degradation of RanBP2

    Ji Won Um;Do Sik Min;Hyewhon Rhim;Jongsun Kim

  • Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways.

    Ji Soo Han;Edward Macarak;Joel Rosenbloom;Kwang Chul Chung

  • Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src.

    Wen Liang Kuo;Kwang Chul Chung;Marsha Rich Rosner

  • Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of α-synuclein

    Eui Nam Lee;Hyun Ju Cho;Choong Hwan Lee;Daekyun Lee

  • Functional interaction of neuronal Cav1.3 L-type calcium channel with ryanodine receptor type 2 in the rat hippocampus.

    Sunoh Kim;Hyung-Mun Yun;Hyung-Mun Yun;Ja-Hyun Baik;Kwang Chul Chung

  • Proteasome Inhibition Induces α-Synuclein SUMOylation and Aggregate Formation

    Yong Man Kim;Won Hee Jang;Martha M. Quezado;Yohan Oh

  • Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.

    Kwang Chul Chung;Ignatius Gomes;Danhui Wang;Lester F. Lau

Frequent Co-Authors

Do Sik Min
Do Sik Min Yonsei University
Hyeyoung Kim
Hyeyoung Kim Yonsei University
Marsha Rich Rosner
Marsha Rich Rosner University of Chicago
Lester F. Lau
Lester F. Lau University of Illinois at Chicago
Min Goo Lee
Min Goo Lee Yonsei University
M. Maral Mouradian
M. Maral Mouradian Rutgers, The State University of New Jersey
Taeg Kyu Kwon
Taeg Kyu Kwon Keimyung University
Hermann Lübbert
Hermann Lübbert Biofrontera (Germany)
Chae-Ok Yun
Chae-Ok Yun Hanyang University
Chung Y. Hsu
Chung Y. Hsu China Medical University

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