Jürgen Kopitz

Overview

Best Publications

• Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin.

  Florian Schütt;Sallyanne Davies;Jürgen Kopitz;Frank G. Holz

  381
  Citations

• Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.

  F G Holz;F Schütt;J Kopitz;G E Eldred

  366
  Citations

• Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture.

  Jürgen Kopitz;Carolina von Reitzenstein;Maria Burchert;Michael Cantz

  322
  Citations

• Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3.

  Jürgen Kopitz;Carolina von Reitzenstein;Sabine André;Herbert Kaltner

  313
  Citations

• Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium.

  Florian Schutt;Marion Bergmann;Frank G Holz;Jurgen Kopitz

  281
  Citations

• Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.

  Jürgen Kopitz;Gunn Kisen;Paul B. Gordon;Peter Bohley

  273
  Citations

• Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration.

  M. Bergmann;F. Schütt;F.G. Holz;J. Kopitz

  269
  Citations

• Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells.

  Sabine André;Hugo Sanchez-Ruderisch;Hiroaki Nakagawa;Malte Buchholz

  228
  Citations

• Calix[n]arene‐Based Glycoclusters: Bioactivity of Thiourea‐Linked Galactose/Lactose Moieties as Inhibitors of Binding of Medically Relevant Lectins to a Glycoprotein and Cell‐Surface Glycoconjugates and Selectivity among Human Adhesion/Growth‐Regulatory Galectins

  Sabine André;Francesco Sansone;Herbert Kaltner;Alessandro Casnati

  199
  Citations

• Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration

  J. Kopitz;F.G. Holz;E. Kaemmerer;F. Schutt

  184
  Citations

• Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells

  Jürgen Kopitz;Sabine André;Carolina Von Reitzenstein;Kees Versluis

  174
  Citations

• Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

  Tim U. Krohne;Nina K. Stratmann;Jürgen Kopitz;Frank G. Holz

  172
  Citations

• Evidence for Stimulation of Tumor Proliferation in Cell Lines and Histotypic Cultures by Clinically Relevant Low Doses of the Galactoside-Binding Mistletoe Lectin, A Component of Proprietary Extracts

  Hans-Joachim Gabius;Francis Darro;Myriam Remmelink;Sabine André

  165
  Citations

• Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice.

  Konstanze Plaschke;Juergen Kopitz;Markus Siegelin;Reinhard Schliebs

  152
  Citations

• Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis.

  Elke Kaemmerer;Florian Schutt;Tim U. Krohne;Frank G. Holz

  152
  Citations

• Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins.

  Hans Christian Siebert;Sabine André;Shan Yun Lu;Martin Frank

  151
  Citations

• Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

  Tuomas Ryhänen;Juha M. T. Hyttinen;Juergen Kopitz;Kirsi Rilla

  147
  Citations

• Determination of structural and functional overlap/divergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM1 in silico and in vitro on human neuroblastoma cells.

  Sabine André;Herbert Kaltner;Martin Lensch;Roland Russwurm

  146
  Citations

• Proteome analysis of lipofuscin in human retinal pigment epithelial cells.

  F. Schutt;B. Ueberle;M. Schnölzer;F.G. Holz

  141
  Citations

• Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD).

  Kai Kaarniranta;Antero Salminen;Eeva-Liisa Eskelinen;Jürgen Kopitz

  141
  Citations