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Medicine

D-Index
74
Citations
29485
World Ranking
19284
National Ranking
9604

Overview

Jonathan R. T. Lakey is affiliated with the University of California, Irvine in the United States. Their research predominantly focuses on the field of Medicine, with significant contributions spanning subfields such as Surgery, Genetics, Endocrinology, Diabetes and Metabolism, Molecular Biology, and Cognitive Neuroscience.

The scientist's work concentrates on topics related to pancreatic function and diabetes, diabetes and associated disorders, diabetes management and research, metabolism, diabetes and cancer, pluripotent stem cells research, cannabis and cannabinoid research, and xenotransplantation and immune response.

Jonathan R. T. Lakey has published research in various venues, frequently contributing to the following journals:

  • American Journal of Biomedical Science & Research
  • Neurology and Neuroscience
  • Cell Transplantation
  • Transplantation
  • Journal of Systems and Integrative Neuroscience

Frequent collaborators in their research include Michael P. Alexander, Slav Danev, Michelle BF Wong, Paul de Vos, and Krista Casazza.

Important recent publications by Jonathan R. T. Lakey include:

  • "Cryopreservation: An Overview of Principles and Cell-Specific Considerations," 2021, Cell Transplantation
  • "Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival," 2020, Biomaterials
  • "Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation," 2021, Communications Biology
  • "Molecular and genetic regulation of pig pancreatic islet cell development," 2020, Development
  • "Functionalization of Alginate with Extracellular Matrix Peptides Enhances Viability and Function of Encapsulated Porcine Islets," 2020, Advanced Healthcare Materials

Best Publications

  • Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

    A. M. J. Shapiro;J. R. T. Lakey;E. A. Ryan;G. S. Korbutt

  • International Trial of the Edmonton Protocol for Islet Transplantation

    A. M James Shapiro;Camillo Ricordi;Bernhard J. Hering;Hugh Auchincloss

  • Five-Year Follow-Up After Clinical Islet Transplantation

    Edmond A. Ryan;Breay W. Paty;Peter A. Senior;David Bigam

  • Hepatitis C virus replication in mice with chimeric human livers

    David F. Mercer;Daniel E. Schiller;John F. Elliott;Donna N. Douglas

  • Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

    Edmond A. Ryan;Jonathan R. T. Lakey;Ray V. Rajotte;Gregory S. Korbutt

  • Successful islet transplantation: continued insulin reserve provides long-term glycemic control.

    Edmond A. Ryan;Jonathan R.T. Lakey;Breay W. Paty;Sharleen Imes

  • Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders.

    Milad Riazifar;M. Rezaa Mohammadi;Egest J. Pone;Ashish Yeri

  • Variables in organ donors that affect the recovery of human islets of Langerhans.

    Lakey;Warnock Gl;Rajotte Rv;Suarez-Alamazor Me

  • Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas

    Ergeng Hao;Björn Tyrberg;Björn Tyrberg;Pamela Itkin-Ansari;Pamela Itkin-Ansari;Jonathan R T Lakey

  • Insulin-stimulated insulin secretion in single pancreatic beta cells.

    Craig A. Aspinwall;Jonathan R.T. Lakey;Robert T. Kennedy

  • A Novel Approach to Increase Human Islet Cell Mass While Preserving β-Cell Function

    Gillian M. Beattie;Anthony M.P. Montgomery;Ana D. Lopez;Ergeng Hao

  • Islet Graft Assessment in the Edmonton Protocol: Implications for Predicting Long-Term Clinical Outcome

    Cale N. Street;Jonathan R.T. Lakey;A.M. James Shapiro;Sharleen Imes

  • Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.

    Lakey;Warnock Gl;Shapiro Am;Korbutt Gs

  • Combination Therapy with Epidermal Growth Factor and Gastrin Induces Neogenesis of Human Islet β-Cells from Pancreatic Duct Cells and an Increase in Functional β-Cell Mass

    Wilma L. Suarez-Pinzon;Jonathan R. T. Lakey;Stephen J. Brand;Alex Rabinovitch

  • Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production

    Alex Rabinovitch;Wilma L. Suarez-Pinzon;Ken Strynadka;Jonathan R. T. Lakey

  • Expansion of mesenchymal stem cells from human pancreatic ductal epithelium

    Karen L Seeberger;Jannette M Dufour;Andrew M James Shapiro;Jonathan R T Lakey

  • Comparison of aortic valve allograft decellularization techniques in the rat.

    Steven R. Meyer;Brian Chiu;Thomas A. Churchill;Linfu Zhu

  • A human β-cell line for transplantation therapy to control type 1 diabetes

    Michiki Narushima;Naoya Kobayashi;Teru Okitsu;Yoshihito Tanaka

  • Portal venous pressure changes after sequential clinical islet transplantation.

    John J. Casey;Jonathan R. T. Lakey;Edmond A. Ryan;Breay W. Paty

  • Cryopreservation: An Overview of Principles and Cell-Specific Considerations.

    David Whaley;Kimia Damyar;Rafal P Witek;Alan Mendoza

Frequent Co-Authors

A. M. James Shapiro
A. M. James Shapiro University of Alberta
Ray V. Rajotte
Ray V. Rajotte University of Alberta
Paul de Vos
Paul de Vos University Medical Center Groningen
Bernhard J. Hering
Bernhard J. Hering University of Minnesota
John F. Elliott
John F. Elliott University of Alberta
Noriaki Tanaka
Noriaki Tanaka Okayama University
Camillo Ricordi
Camillo Ricordi University of Miami
Robert T. Kennedy
Robert T. Kennedy University of Michigan–Ann Arbor
Monica M. Palcic
Monica M. Palcic Carlsberg Laboratory
John K. Critser
John K. Critser University of Missouri

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